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Browsing Tag

Pathology

80 posts
SScience
Epigenetic editing enables safer and more effective T cell therapies
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New hybrid lens design drastically cuts 3D microscopy costs and complexity

  • June 10, 2026
A team led by Raju Tomer, professor of biological sciences at Columbia University, has created a new design…
HHealth
New PET imaging approach may enable early CTE diagnosis
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New PET imaging approach may enable early CTE diagnosis

  • June 1, 2026
A first-in-class PET imaging approach can accurately detect a biomarker for chronic traumatic encephalopathy (CTE), a devastating neurodegenerative…
HHealth
Berberine improves cognitive function in diabetic encephalopathy mice
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Researchers uncover new clues about the origin of Alzheimer’s tau tangles

  • May 30, 2026
Researchers at Columbia University have uncovered new clues about the earliest molecular events that may trigger Alzheimer’s disease,…
HHealth
Study: Universal transcriptomic hallmarks of mammalian ageing and mortality. Image Credit: Igor Kyrlytsya / Shutterstock
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Scientists uncover shared gene signatures that reveal how mammals age

  • May 29, 2026
A sweeping study across four mammalian species shows that aging leaves a shared molecular fingerprint, opening new ways…
HHealth
Regular mammograms linked to longer survival in women over 80
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Obesity alters tumor environment promoting invasive breast cancer growth

  • May 29, 2026
Obesity may change how early-stage breast cancer becomes invasive, according to a study by University of Oklahoma researchers…
HHealth
Study explores scent's role in social status perceptions
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Study challenges assumptions about testosterone’s role in brain cancer

  • May 9, 2026
Scientists have long suspected that androgens, male sex hormones like testosterone, may help tumors grow because the hormones…
HHealth
Interviews with Outstanding Authors (2026)
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Interviews with Outstanding Authors (2026)

  • May 7, 2026
In 2025, many ATM authors make outstanding contributions to our journal. Their articles published with us have received…
SScience
Lysosomal acidity fine-tunes reactive species production in macrophages
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Pathogens drive inflammation by reprogramming host cell metabolic processes

  • April 30, 2026
An intestinal pathogen reshapes the gut environment to fuel its own colonization and cause diseases, a multi-institutional team…
HHealth
Compact bNIRS technology could become a diagnostic toolkit for dementia
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Unraveling the mystery of cognitive resilience in aging brains

  • April 25, 2026
The mystery of cognitive resilience Some brains resist Alzheimer’s, even when the disease is already present. Researchers at…
TTechnology
Electrical stimulation predicts recovery potential after acute nerve injuries
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Pinecone-inspired conduit enables suture-free repair of nerve injuries

  • April 22, 2026
As the authors detail, PNI is a prevalent neurological condition that often causes permanent sensory and motor dysfunction,…
HHealth
Neurons in Alzheimer
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Alzheimer’s monoclonal antibodies fail to deliver meaningful results

  • April 21, 2026
Despite successfully removing amyloid plaques from the brain, widely anticipated antibody therapies fail to deliver meaningful cognitive improvements,…
HHealth
Innate immune activation and microglial transition during neurodegeneration. (A) During neurodegeneration, distressed neurons release DAMPs such as mtDNA, ROS, HMGB1, aberrant proteins, and pTau–bound RNA. These signals activate resident microglia and astrocytes, which then recruit peripheral immune cells. As shown in more detail in B, activated microglia upregulate PRRs, including TLRs, RAGE, and cGAS, enabling detection of neuron-derived DAMPs. Engagement of PRRs induces proinflammatory gene expression programs and activates inflammasome pathways that promote release of chemokines and cytokines into the CNS parenchyma. As microglia transition from homeostatic to reactive states in a TREM2-dependent manner, damage-associated microglia increase MHC-II expression to support antigen presentation and coordination of adaptive immune responses that attempt to limit neurodegeneration.
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How the immune system may influence Alzheimer’s, Parkinson’s, and related diseases

  • April 17, 2026
A sweeping review shows how the brain’s immune defenses can both fight and fuel neurodegeneration, revealing why timing,…
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