Pharmacology/Toxicology - Israel News Beep | NewsBeep.com

Systematic optimization and characterization of the MidTAC platform for targeted protein degradation

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Systematic optimization and characterization of the MidTAC platform for targeted protein degradation

October 19, 2026

Pohl C, Dikic I. Cellular quality control by the ubiquitin-proteasome system and autophagy. Science. 2019;366:818–22. Article PubMed Google…

Probing the many benefits of GLP-1 receptor agonists

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Probing the many benefits of GLP-1 receptor agonists

October 6, 2026

RESEARCH HIGHLIGHT 05 October 2026 Glucagon-like peptide 1 (GLP-1) receptor agonists are approved for the treatment of type…

The cellular landscape of druggable RNA-binding proteins

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The cellular landscape of druggable RNA-binding proteins

September 30, 2026

Gerstberger, S., Hafner, M. & Tuschl, T. A census of human RNA-binding proteins. Nat. Rev. Genet. 15, 829–845…

Cerebral edema in maple syrup urine disease: spectrum of clinical presentation and treatment outcomes | Orphanet Journal of Rare Diseases

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Cerebral edema in maple syrup urine disease: spectrum of clinical presentation and treatment outcomes | Orphanet Journal of Rare Diseases

November 19, 2025

Seven patients (6 males and 1 female) presented with ten episodes of acute encephalopathy, and cerebral edema was…

Nutritional management of metabolic disorders in neonates and infants in Saudi Arabia: consensus recommendations | Orphanet Journal of Rare Diseases

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Nutritional management of metabolic disorders in neonates and infants in Saudi Arabia: consensus recommendations | Orphanet Journal of Rare Diseases

November 17, 2025

General principles of nutritional management Early diagnosis and management of IEM are essential. Newborn screening programs for IEM…

The global burden of motor neuron disease: a systematic and additional analysis of global burden disease study 2021 | Orphanet Journal of Rare Diseases

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The global burden of motor neuron disease: a systematic and additional analysis of global burden disease study 2021 | Orphanet Journal of Rare Diseases

November 10, 2025

Data source The GBD 2021 employed the most up-to-date epidemiological data, complemented by refined and standardized methodologies, to…

Dual abstinence from nicotine vaping and cannabis use among young people: secondary analyses from two U.S.-based randomized controlled trials of vaping cessation | Substance Abuse Treatment, Prevention, and Policy

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Dual abstinence from nicotine vaping and cannabis use among young people: secondary analyses from two U.S.-based randomized controlled trials of vaping cessation | Substance Abuse Treatment, Prevention, and Policy

November 2, 2025

Among 1,503 adolescents randomized, the 7-month follow-up rate was 70.8% (n = 1,064). Data on cannabis use was missing for…

Clinical manifestations and treatment of peripheral odontogenic keratocysts: two cases and a literature review | Orphanet Journal of Rare Diseases

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Clinical manifestations and treatment of peripheral odontogenic keratocysts: two cases and a literature review | Orphanet Journal of Rare Diseases

October 30, 2025

POKC is a particular type of OKC. Investigating the origin of POKC is critical, and its origin may…

Genetic investigation of sinopulmonary diseases in Vietnam: seeking specific causes from non-specific symptoms | Orphanet Journal of Rare Diseases

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Genetic investigation of sinopulmonary diseases in Vietnam: seeking specific causes from non-specific symptoms | Orphanet Journal of Rare Diseases

October 15, 2025

O’Donnell AE. Bronchiectasis – a clinical review. N Engl J Med. 2022;387(6):533–45. Article PubMed Google Scholar Flume PA,…

Synthetic lethality in cancer drug discovery: challenges and opportunities

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Synthetic lethality in cancer drug discovery: challenges and opportunities

September 11, 2025

Hartwell, L. H., Szankasi, P., Roberts, C. J., Murray, A. W. & Friend, S. H. Integrating genetic approaches…