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Browsing Tag

Receptor

144 posts
SScience
Study shows DHPS enzyme controls macrophage maturation across multiple organs
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Targeting glutamine metabolism enhances CAR-macrophage cancer therapy

  • April 21, 2026
Tumor-associated macrophages (TAMs) within the tumor microenvironment (TME) exhibit significant metabolic dysregulation, which impairs their antitumor function. Specifically,…
SScience
New imaging technique enhances live-cell visualization in standard lab setups
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Researchers discover how cell membrane composition drives cancer proliferation

  • April 17, 2026
Cells are enveloped by a lipid membrane that gives them structure and provides a barrier between the cell…
HHealth
Innate immune activation and microglial transition during neurodegeneration. (A) During neurodegeneration, distressed neurons release DAMPs such as mtDNA, ROS, HMGB1, aberrant proteins, and pTau–bound RNA. These signals activate resident microglia and astrocytes, which then recruit peripheral immune cells. As shown in more detail in B, activated microglia upregulate PRRs, including TLRs, RAGE, and cGAS, enabling detection of neuron-derived DAMPs. Engagement of PRRs induces proinflammatory gene expression programs and activates inflammasome pathways that promote release of chemokines and cytokines into the CNS parenchyma. As microglia transition from homeostatic to reactive states in a TREM2-dependent manner, damage-associated microglia increase MHC-II expression to support antigen presentation and coordination of adaptive immune responses that attempt to limit neurodegeneration.
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How the immune system may influence Alzheimer’s, Parkinson’s, and related diseases

  • April 17, 2026
A sweeping review shows how the brain’s immune defenses can both fight and fuel neurodegeneration, revealing why timing,…
HHealth
Asian woman suffering from stomachache caused by (irritable bowel syndrome hand taking medicine
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Higher mortality risk in IBS patients using antidepressants

  • April 13, 2026
A massive real-world study raises new safety questions about widely used IBS treatments, revealing that some commonly prescribed…
HHealth
Gut microbiota regulates intestinal epithelial cell function and plasticity
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Gut microbiota regulates intestinal epithelial cell function and plasticity

  • April 8, 2026
A research team led by scientists from the State University of Campinas (UNICAMP) in São Paulo, Brazil, has…
SScience
Early B cell response prevents Oropouche virus from reaching the brain
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Molecular switch in neurons found to limit the regrowth of damaged axonal fibers

  • April 1, 2026
Researchers from the Icahn School of Medicine at Mount Sinai have discovered a molecular switch in neurons that…
HHealth
Early B cell response prevents Oropouche virus from reaching the brain
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Highly potent opioid shows potential as therapy for pain and opioid use disorder

  • April 1, 2026
Researchers at the National Institutes of Health (NIH) have identified a novel, highly potent opioid that shows potential…
HHealth
Study: Bisphenol a exposure and major depressive disorder: an integrative analysis combining network toxicology, molecular docking, genetic epidemiology, and transcriptomic validation. Image Credit: monticello / Shutterstock
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How could bisphenol A raise depression risk? Study identifies six key molecular targets

  • April 1, 2026
Researchers combined genetic epidemiology, transcriptomics, molecular docking, and mouse experiments to show how a common endocrine-disrupting chemical may…
HHealth
Targeting bacterial communication may offer antibiotic-free wound therapy
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GLP-1 medications show mixed effects on body contouring outcomes

  • March 27, 2026
For patients undergoing body contouring surgery to remove excess abdominal skin after massive weight loss, use of GLP-1 weight-loss medications may have mixed effects…
HHealth
Healthy diet found to reduce chronic pain beyond weight loss
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New pathway enhances brown fat thermogenesis and metabolic health

  • March 25, 2026
Researchers have determined how a key protein activates brown fat by expanding blood vessels and nerves in the…
HHealth
Scientists map gut microbiota associated with coronary artery disease
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Medicare reforms improve medication adherence among older adults with heart disease

  • March 24, 2026
Medicare beneficiaries with heart disease or major cardiovascular risk factors reported less cost-related medication non-adherence-skipping or reducing doses,…
HHealth
Affordable drug found to be effective in treating seriously ill COVID-19 patients
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Study revises the understanding of neutrophil dynamics during respiratory viral infection

  • March 24, 2026
Neutrophil infiltration is a hallmark of pulmonary inflammation during respiratory viral infections, yet the origin of these cells…
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