New nanoparticle system boosts scalable production of therapeutic exosomes
Researchers from Xi’an Jiaotong-Liverpool University (XJTLU) in China have developed a streamlined process that makes it easier to…
CSF1R T567M mutation induces microglial dysfunction and synaptic impairment in patient iPSC-derived cerebral organoids of CSF1R-related disorder
Ayrignac X, Carra-Dalliere C, Codjia P, Mouzat K, Castelnovo G, Ellie E, et al. Evaluation of CSF1R-related adult…
Viagra ingredient improves symptoms in patients with Leigh syndrome
Sildenafil – an active ingredient also marketed under the name of Viagra – improves symptoms in patients with…
ATP delivery fixes dysfunctional dopamine packaging in Parkinson’s neurons
A new study shows how dysfunctional packaging of the neurotransmitter dopamine triggers toxic processes in neurons – and…
Scientists discover how muscle stem cells “flip a switch” to rebuild damaged muscle
Scientists at the University of California, Irvine’s School of Pharmacy & Pharmaceutical Sciences have discovered how muscle stem cells “flip…
Researchers reveal why SuperAgers retain youthful brain cell signatures into their 80s
A multiomic atlas of the aging human hippocampus uncovers how epigenetic regulation of neural stem cells and immature…
Alpha-Ketoglutarate Enhances Adipose-Derived Stem Cells Survival in Wound Healing by Hypoxia-Inducible Factor 1-Alpha-Mediated Redox Homeostasis and Glycogen-Dependent Bioenergetics
BACKGROUND Adipose-derived stem cells (ADSCs) hold significant therapeutic potential for regenerative medicine, particularly in wound healing, owing to…
Genetic mismatch identified as major risk factor in cord blood transplantation
A Japanese study of more than 7,400 patients has identified a genetic mismatch that sharply increases the risk…
Researchers find new way to halt leukemia stem cell growth
In a new study published in Nature Communications, a research team at the University of Oslo have examined…
Muscle stem cells become more resistant but less restorative over time
Tissue repair and regeneration after injury slow down with aging. In muscles, this happens because muscle stem cells…
Lab-grown corticospinal neurons offer new models for ALS and spinal injuries
Researchers have developed a way to grow a highly specialized subset of brain nerve cells that are involved…
New FDA cell and gene therapy oversight system comes with risks
At a Food and Drug Administration cell and gene therapy (CGT) roundtable last June, most speakers pushed for…