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Browsing Tag

Synapse

10 posts
HHealth
Immune cells communicate across a continuous, bidirectional circuit between the CNS and periphery. Immune cells from across the body engage CNS tissues and, in turn, are shaped by signals returning from the brain. (Left) Under peripheral equilibrium, immune effectors mobilized from visceral organs, secondary lymphoid organs, hematopoietic tissues, and the peripheral nervous system (PNS) - including CD4+ and CD8+ T cells, B cells, monocytes (top 3 cell types), NK cells, dendritic cells, mast cells, neutrophils, and innate lymphoid cells (bottom cluster of cells) - engage the CNS in a homeostatic dialogue that supports neural cell health, plasticity, and repair, sustaining a protective environment. (Right) Age-associated dysfunction across the same peripheral compartments reshapes this circuit: altered immune effectors enter the CNS and contribute to shifting the local environment toward a degenerative state in which microglia adopt disease-associated programs, astrocytes become reactive, and neurons accumulate pathology. This model underscores how the same circuitry can yield protective or pathogenic outcomes and that neurodegeneration is downstream of dysfunctional brain-immune crosstalk. Study: Neurodegeneration as a dysregulation of neuroimmune crosstalk
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Disrupted brain-immune signaling may help drive neurodegeneration

  • August 24, 2026
From gut-primed T cells to microglial signaling and persistent gene-regulatory states, researchers map an intricate immune network that…
NNutrition
Lutein-zeaxanthin supplements may boost attention in teenagers
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Lutein-zeaxanthin supplements may boost attention in teenagers

  • June 30, 2026
Writing in Nutrition Research, Adrian Lopresti and Stephen Smith from Clinical Research Australia report that supplementation with 10…
SScience
Cancer cells found to use ketones as alternate fuel for growth
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Damon Runyon supports young scientists driving cancer research innovation

  • April 12, 2026
The Damon Runyon Cancer Research Foundation has named 13 new Damon Runyon Fellows, exceptional postdoctoral scientists conducting basic and…
SScience
AI tool SeeMe detects hidden signs of consciousness in brain injury patients
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RNA barcoding maps neural connections with unprecedented resolution

  • April 8, 2026
By tagging neurons with molecular “barcodes,” researchers mapped connections among thousands of neurons in the mouse brain with…
HHealth
Cancer cells found to use ketones as alternate fuel for growth
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Unmasking the hyperactive circuitry of early Alzheimer’s

  • March 9, 2026
Neuroscientists at King’s College London have pinpointed a mechanism behind the increased neural connectivity observed in the very early stages of Alzheimer’s…
HHealth
AI toolset reveals links between lung fibrosis and aging
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Aging brains struggle to recycle synaptic proteins

  • February 3, 2026
As we age, we begin to lose the connections that wire up our brains-and neuroscientists aren’t sure why. …
HHealth
Struggling to make ends meet may slow brain development in infants
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Struggling to make ends meet may slow brain development in infants

  • January 12, 2026
A new study shows that whether families can reliably meet basic needs, not just how much they earn,…
SScience
AI tool SeeMe detects hidden signs of consciousness in brain injury patients
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Engineered sensor reveals the brain’s hidden chemical conversations

  • December 24, 2025
Scientists have engineered a protein able to record the incoming chemical signals of brain cells (as opposed to…
SScience
Neuroscientists uncover a surprising role for "Frazzled" protein in the nervous system of fruit flies
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Neuroscientists uncover a surprising role for “Frazzled” protein in the nervous system of fruit flies

  • October 31, 2025
Florida Atlantic University neuroscientists have uncovered a surprising role for a protein named “Frazzled” (known as DCC in…
HHealth
Boosting PI31 to restore synaptic function and prevent neurodegeneration
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Boosting PI31 to restore synaptic function and prevent neurodegeneration

  • September 16, 2025
One fundamental feature of neurodegenerative diseases is a breakdown in communication. Even before brain cells die, the delicate…
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