Researchers reveal why SuperAgers retain youthful brain cell signatures into their 80s
A multiomic atlas of the aging human hippocampus uncovers how epigenetic regulation of neural stem cells and immature…
Study reveals poxvirus’s unique DNA clamp for gene activation
A research team at the University of Würzburg has deciphered another aspect of poxviral gene activation. The study…
Transcription factor HOXD13 drives melanoma growth and immune evasion
A molecule that helps regulate gene activity has also been shown to drive skin cancer growth and tumors’…
New diagnostic framework addresses challenges of rapidly-mutating RNA viruses
The rapid evolutionary dynamics of RNA viruses, driven by high mutation rates and the consequent formation of complex…
Scientists uncover new mechanism initiating gene transcription
Scientists at IOCB Prague are uncovering new details of gene transcription. They have identified a previously unknown molecular…
Scientists discover how stem cells navigate and repair brain damage after stroke
Some parts of our bodies bounce back from injury in fairly short order. The outer protective layer of…
New findings show why the human intestine uniquely presents gluten to T cells
New evidence shows that human M cells act as fully fledged antigen-presenting cells, processing and presenting gluten peptides…
Breakthrough platform reveals the choreography of mammalian transcription
Life’s instructions are written in DNA, but it is the enzyme RNA polymerase II (Pol II) that reads…
Researchers discover new mutation hotspot in the human genome
Researchers have discovered new regions of the human genome particularly vulnerable to mutations. These altered stretches of DNA…
Breast cancer cells use a molecular switch to survive stress
Cells are regularly faced with environmental stresses that may damage or destroy them. To survive, they quickly adjust…
Scientists map the genetic control system behind FOXP3 in immune cells
The immune system faces a delicate balancing act: it must be aggressive enough to fight infections and cancer,…
New insights reveal how TCF and LEF proteins control Wnt signaling and disease progression
Researchers have unveiled the intricate molecular mechanisms governing TCF/LEF-mediated transcription in the canonical Wnt pathway, identifying these proteins…