New gene signature predicts immunotherapy success for bone marrow cancers
A team led by researchers from the German Cancer Research Center (DKFZ), the HI-STEM Stem Cell Institute, and Medical…
New drug delivers promising survival gains in pancreatic cancer
About 90% of people with pancreatic cancer have pancreatic ductal adenocarcinoma (PDAC), which is driven by an activating mutation in…
Combination therapy overcomes ferroptosis resistance in β-catenin-mutant hepatocellular carcinoma
Background and aims The aberrant activation of the mTOR pathway and its crosstalk with other signaling cascades represent…
Autophagy modulation emerges as a strategy against cisplatin-resistant gastric cancer
Drug resistance remains one of the greatest obstacles to successful treatment of gastric cancer, limiting the long-term effectiveness…
Blocking ZFP36L2 protein may disrupt colorectal cancer metastatic growth
Digestion is hard on the cells that line the human gut, and they are constantly being shed and…
Novel drug puts cancer cells under extreme metabolic stress
Cancer cells have a voracious appetite for sugar-using it to fuel their rapid growth. This is why many…
Dual immunotherapy with neoadjuvant chemotherapy shows encouraging activity in ERBB2-negative breast cancer
A combination of two immunotherapy drugs showed encouraging activity when added to standard chemotherapy given prior to surgery…
New ultrasound technique breaches blood brain barrier to treat gliomas
In a promising sign for the potential of focused sound waves to improve care for brain tumors, UVA…
New strategy combines cancer immunotherapy and gene therapy in a single nanoparticle
Cancer cells survive by hiding from the immune system’s surveillance. A KAIST research team has developed a new…
Researchers uncover molecular switch controlling nutrient-driven cell growth
Cells carry their own growth switches. When enough nutrients-amino acids in particular-are available, cells flip this switch on…
Engineered probiotic bacteria boost immune attack against pancreatic cancer
Cancer immunotherapies have transformed treatment for many cancers, but pancreatic cancer remains especially difficult to treat. One major…
Occult hepatitis B mutations drive liver cancer growth via Akt mTOR pathway
Occult hepatitis B virus (OBI) infection presents a significant global health challenge, notoriously flying under the radar of…