{"id":100584,"date":"2025-10-27T13:34:10","date_gmt":"2025-10-27T13:34:10","guid":{"rendered":"https:\/\/www.newsbeep.com\/il\/100584\/"},"modified":"2025-10-27T13:34:10","modified_gmt":"2025-10-27T13:34:10","slug":"fatigue-induced-biomechanical-decoupling-at-l4-s1-discs-mechanism-of-disc-degeneration-in-chronic-low-back-pain-bmc-musculoskeletal-disorders","status":"publish","type":"post","link":"https:\/\/www.newsbeep.com\/il\/100584\/","title":{"rendered":"Fatigue-induced biomechanical decoupling at L4-S1 discs: mechanism of disc degeneration in chronic low back pain | BMC Musculoskeletal Disorders"},"content":{"rendered":"

Cieza A, Causey K, Kamenov K, Hanson SW, Chatterji S, et al. Global estimates of the need for rehabilitation based on the global burden of disease study 2019: a systematic analysis for the global burden of disease study 2019. Lancet. 2020;396(10267):2006\u201317.<\/p>\n

PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Treede R-D, Rief W, Barke A, Aziz Q, Bennett MI, et al. A classification of chronic pain for ICD-11. Pain. 2015;156(6):1003\u20137.<\/p>\n

PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Belsuzarri TAB, Barletta EA, Urena ARB, Paz DDEA, Sparapani FVDC, et al. The natural history of patients with acute disc herniation: A series of 150 cases. Coluna\/Columna. 2020;19(2):116\u20139.<\/p>\n


\n Google Scholar<\/a>\u00a0\n <\/p>\n

de David CN, Deligne LdMC, da Silva RS, Malta DC, Duncan BB, et al. The burden of low back pain in brazil: estimates from the global burden of disease 2017 study. Popul Health Metrics. 2020;18(S1):12.<\/p>\n


\n Google Scholar<\/a>\u00a0\n <\/p>\n

Papcke C, Batista JF, Neto V, Vendramini PSD, Machado IC. Low back pain leads to a protective action of pain on dynamic postural stability. Res Sports Med. 2022;30(6):628\u201340.<\/p>\n

PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Jubany J, Danneels L. The influence of fatigue and chronic low back pain on muscle recruitment patterns following an unexpected external perturbation. BMC Musculoskelet Disord. 2017;18(1):161.<\/p>\n

PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Liu Q, Zhang LIUB, Zhang KP, Zhang T. Effect of fatigue load on internal mechanical properties of the intervertebral disc. Int J Morphol. 2020;38(6):1597\u2013605.<\/p>\n


\n Google Scholar<\/a>\u00a0\n <\/p>\n

Wilke H-J, Volkheimer D. Basic Biomechanics of the Lumbar Spine, in Biomechanics of the Spine. 2018:51\u201367.<\/p>\n

Collaborators GM. Global, regional, and national age-sex-specific mortality and life expectancy, 1950\u20132017: a systematic analysis for the global burden of disease study 2017. Lancet. 2018;392(10159):1684\u2013735.<\/p>\n


\n Google Scholar<\/a>\u00a0\n <\/p>\n

Adams MA, Dolan P. Intervertebral disc degeneration: evidence for two distinct phenotypes. J Anat. 2012;221(6):497\u2013506.<\/p>\n

PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Roberts S, Menage J, Urban JPG. Biochemical and structural properties of the cartilage end-plate and its relation to the intervertebral disc. Spine. 1989;14(2):166\u201374.<\/p>\n

PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Bibby SR, Fairbank JC, Urban MR. Cell viability in scoliotic discs in relation to disc deformity and nutrient levels. Spine (Phila Pa 1976). 2002;27(20):2220\u20138.<\/p>\n

PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Chan WCW, Sze KL, Samartzis D, Leung VYL, Chan D. Structure and biology of the intervertebral disk in health and disease. Orthop Clin North Am. 2011;42:447\u201364.<\/p>\n

PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Wu DJ, Chen K, Wei XZ, Ni HJ, Yu SZ, et al. Analysis of intervertebral disc-related genes. Genet Mol Res. 2014;13(1):2032\u20138.<\/p>\n

PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Miyazaki M, Hymanson HJ,Morishita Y, He W, Zhang H, et al. Kinematic analysis of the relationship between sagittal alignment and disc degeneration in the cervical spine. Spine (Phila Pa 1976). 2008;33(23):E870\u20136.<\/p>\n

PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Pynt J, Mackey MG, Higgs J. Kyphosed seated postures: extending concepts of postural health beyond the office. J Occup Rehabil. 2008;18(1):35\u201345.<\/p>\n

PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Cho M, Han J-S, Kang S, Ahn C-H, Kim D-H, et al. Biomechanical effects of different sitting postures and physiologic movements on the lumbar spine: a finite element study. Bioengineering. 2023;10(9):1051. https:\/\/doi.org\/10.3390\/bioengineering10091051<\/a>.<\/p>\n

Jung K-S, Jung J-H, In T-S, Cho H-Y. Effects of prolonged sitting with slumped posture on trunk muscular fatigue in adolescents with and without chronic lower back pain. Medicina. 2021;57(1):3. https:\/\/doi.org\/10.3390\/medicina57010003<\/a>.<\/p>\n

Vergroesen PP, Kingma I, Emanuel KS, Hoogendoorn RJ, Welting TJ, et al. Mechanics and biology in intervertebral disc degeneration: a vicious circle. Osteoarthritis Cartilage. 2015;23(7):1057\u201370.<\/p>\n

PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Papa EV, Garg H, Dibble LE. Acute effects of muscle fatigue on anticipatory and reactive postural control in older individuals. J Geriatr Phys Ther. 2015;38(1):40\u20138.<\/p>\n

PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Wan J-j, Qin Z, Wang P-y, Sun Y, Liu X. Muscle fatigue: general understanding and treatment. Exp Mol Med. 2017;49(10):e384\u2013384.<\/p>\n


\n Google Scholar<\/a>\u00a0\n <\/p>\n

Sato K, Yonezawa KS. In vivo intradiscal pressure measurement in healthy individuals and in patients with ongoing back problems. Spine (Phila Pa 1976). 1999;24(23):2468\u201374.<\/p>\n

PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Wilke H, Neef P, Caimi M, Hoogland T, Claes L. New in vivo measurements of pressures in the intervertebral disc in daily life. Spine (Phila Pa 1976). 1999;24(8):755\u201362.<\/p>\n

PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Association. WM. World medical association declaration of helsinki: ethical principles for medical research involving human subjects. JAMA. 2013;310(20):2191\u20134.<\/p>\n


\n Google Scholar<\/a>\u00a0\n <\/p>\n

Shafshak TS, Elnemr R. The visual analogue scale versus numerical rating scale in measuring pain severity and predicting disability in low back pain. JCR: Journal of Clinical Rheumatology. 2021;27(7):282\u20135.<\/p>\n

PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Mitchell K, Porter M, Anderson L, Phillips C, Arceo G, et al. Differences in lumbar spine and lower extremity kinematics in people with and without low back pain during a step-up task: a cross-sectional study. BMC Musculoskelet Disord. 2017;18(1):369.<\/p>\n

PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Fairbank J, Pynsent P. The oswestry disability index. Spine(Phila Pa 1976). 2000;25(22):2940\u201352.<\/p>\n

PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Xi X, Ling Z, Wang C, Gu C, Zhan X, et al. Lumbar segment-dependent soft tissue artifacts of skin markers during in vivo weight-bearing forward-backward bending. Front Bioeng Biotechnol. 2022;10:960063.<\/p>\n

PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Xi X, Zhang L, Yu H, Qin Y, Jia L, et al. Different spatial characteristic changes in lumbopelvic kinematics before and after fatigue: comparison between people with and without low back pain. Bioengineering. 2025;12(3):214.<\/p>\n

PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Asgari N, Sanjari MA, Esteki A. Local dynamic stability of the spine and its coordinated lower joints during repetitive lifting: effects of fatigue and chronic low back pain. Hum Mov Sci. 2017;54:339\u201346.<\/p>\n

PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Papi E, Bull AMJ, McGregor AH. Spinal segments do not move together predictably during daily activities. Gait Posture. 2019;67:277\u201383.<\/p>\n

PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

von Arx M, Liechti M, Connolly L, Bangerter C, Meier ML, et al. From stoop to squat: a comprehensive analysis of lumbar loading among different lifting styles. Front Bioeng Biotechnol. 2021;9:769117.<\/p>\n


\n Google Scholar<\/a>\u00a0\n <\/p>\n

Wu G, Siegler S, Allard P, Kirtley C, Leardini A, et al. Standardization and terminology committee of the international society of biomechanics. ISB recommendation on definitions of joint coordinate system of various joints for the reporting of human joint motion\u2013part I: ankle, hip, and spine. international society of biomechanics. J Biomech. 2002;35(4):543\u20138.<\/p>\n

PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Li G, Passias P, Kozanek M, Shannon BD, Li G, et al. Interobserver reliability and intraobserver reproducibility of powers ratio for assessment of atlanto-occipital junction: comparison of plain radiography and computed tomography. Eur Spine J. 2009;18(4):577\u201382.<\/p>\n

PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Li G, Van de Velde SK, Bingham JT. Validation of a non-invasive fluoroscopic imaging technique for the measurement of dynamic knee joint motion. J Biomech. 2008;41(7):1616\u201322.<\/p>\n

PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Wang S, Xia Q, Passias P, Wood K, Li G. Measurement of geometric deformation of lumbar intervertebral discs under in-vivo weightbearing condition. J Biomech. 2009;42(6):705\u201311.<\/p>\n

PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Kou BW, Han Y, Hao YG, Xu HX, Wen WQ, et al. Morphological changes and strain characteristics of lumbar intervertebral disc during sitting in forward flexion. Zhongguo Zuzhi Gongcheng Yanjiu. 2022;26(36):5792\u20137.<\/p>\n


\n Google Scholar<\/a>\u00a0\n <\/p>\n

Adams MA, Hutton WC. Gradual disc prolapse. Spine. 1985;10(6):524\u201331.<\/p>\n

PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Schmidt H, Heuer F, Simon U, Kettler A, Rohlmann A, et al. Application of a new calibration method for a three-dimensional finite element model of a human lumbar annulus fibrosus. Clin Biomech. 2006;21(4):337\u201344.<\/p>\n


\n Google Scholar<\/a>\u00a0\n <\/p>\n

Dong Zhen-hui. Role of local biomechanical factors in pathogenesis of L5\/S1 disc herniation. J Clin Rehabilitative Tissue Eng Res. 2010;14(15):2744\u20137.<\/p>\n


\n Google Scholar<\/a>\u00a0\n <\/p>\n

Inoue N, Or\u00edas AAE. Biomechanics of the lumbar facet joint. Spine Surg Relat Res. 2019;4(1):1\u20137.<\/p>\n

PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Velnar T, Gradisnik L. Endplate role in the degenerative disc disease: a brief review. World J Clin Cases. 2023;11(1):17\u201329.<\/p>\n

PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Iatridis J, Kumar S, Foster R, Weidenbaum M, Mow V. Shear mechanical properties of human lumbar annulus fibrosus. J Orthop Res. 1999;17(5):732\u20137.<\/p>\n

PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Nguyen C, Poiraudeau S, Rannou F. From modic 1 vertebral-endplate subchondral bone signal changes detected by MRI to the concept of \u2018active discopathy. Ann Rheum Dis. 2015;74(8):1488\u201394.<\/p>\n

PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Kirkaldy-Willis WH, Farfan HF. Instability of the lumbar spine. Clin Orthop Relat Res. 1982;(165):110\u201323. PMID: 6210480.<\/p>\n

Jensen RK, Leboeuf-Yde C, Wedderkopp N, Sorensen JS, Jensen TS, et al. Is the development of modic changes associated with clinical symptoms? A 14-month cohort study with MRI. Eur Spine J. 2012;21(11):2271\u20139.<\/p>\n

PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Reulen H-J, Muller A, Ebeling U. Microsurgical anatomy of the lateral approach to extraforaminal lumbar disc herniations. Neurosurgery. 1996;39(2):345\u201351.<\/p>\n

PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Byrne RM, Aiyangar AK, Zhang X. A dynamic radiographic imaging study of lumbar intervertebral disc morphometry and deformation in vivo. Sci Rep. 2019;9(1):15490.<\/p>\n

PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Menon RG, Zibetti MVW, Pendola M, Regatte RR. Measurement of three-dimensional internal dynamic strains in the intervertebral disc of the lumbar spine with mechanical loading and golden\u2010angle radial sparse parallel\u2010magnetic resonance imaging. J Magn Reson Imaging. 2021;54(2):486\u201396.<\/p>\n

PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Roussouly P, Berthonnaud E, Dimnet J. Geometrical and mechanical analysis of lumbar lordosis in an asymptomatic population: proposed classification. Rev Chir Orthop Reparatrice Appar Mot. 2003;89(7):632\u20139.<\/p>\n

PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Barrey C, Jund J, Noseda O, Roussouly P. Sagittal balance of the pelvis-spine complex and lumbar degenerative diseases. A comparative study about 85 cases. Eur Spine J. 2007;16(9):1459\u201367.<\/p>\n

PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Chan DD, Neu CP. Intervertebral disc internal deformation measured by displacements under applied loading with MRI at 3T. Magn Reson Med. 2013;71(3):1231\u20137.<\/p>\n


\n Google Scholar<\/a>\u00a0\n <\/p>\n

O\u2019Connell GD, Vresilovic EJ, Elliott DM. Human intervertebral disc internal strain in compression: the effect of disc region, loading position, and degeneration. J Orthop Res. 2010;29(4):547\u201355.<\/p>\n

PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Antoniou J, Steffen T, Nelson F, Winterbottom N, Hollander AP, et al. The human lumbar intervertebral disc: evidence for changes in the biosynthesis and denaturation of the extracellular matrix with growth, maturation, ageing, and degeneration. J Clin Invest. 1996;98(4):996\u20131003.<\/p>\n

PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Singh K, Phillips FM. The biomechanics and biology of the spinal degenerative cascade. Semin Spine Surg. 2005;17(3):128\u201336.<\/p>\n


\n Google Scholar<\/a>\u00a0\n <\/p>\n

Fields AJ, Ballatori A, Liebenberg EC. Contribution of the endplates to disc degeneration. Curr Mol Biol Rep. 2018;4(4):151\u201360.<\/p>\n

PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n","protected":false},"excerpt":{"rendered":"Cieza A, Causey K, Kamenov K, Hanson SW, Chatterji S, et al. Global estimates of the need for…\n","protected":false},"author":2,"featured_media":100585,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[5],"tags":[66595,114,66593,4741,1991,85,28049,3861,66594,46,14542,10539,7307,7832],"class_list":["post-100584","post","type-post","status-publish","format-standard","has-post-thumbnail","category-business","tag-biomechanical-mechanism","tag-business","tag-chronic-low-back-pain","tag-epidemiology","tag-fatigue","tag-il","tag-in-vivo","tag-internal-medicine","tag-intervertebral-disc-strain","tag-israel","tag-orthopedics","tag-rehabilitation","tag-rheumatology","tag-sports-medicine"],"_links":{"self":[{"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/posts\/100584","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/comments?post=100584"}],"version-history":[{"count":0,"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/posts\/100584\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/media\/100585"}],"wp:attachment":[{"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/media?parent=100584"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/categories?post=100584"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/tags?post=100584"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}