{"id":164523,"date":"2025-12-02T18:14:10","date_gmt":"2025-12-02T18:14:10","guid":{"rendered":"https:\/\/www.newsbeep.com\/il\/164523\/"},"modified":"2025-12-02T18:14:10","modified_gmt":"2025-12-02T18:14:10","slug":"are-south-indians-at-higher-risk-of-heart-disease-new-instem-study-reveals-unique-genetic-signature","status":"publish","type":"post","link":"https:\/\/www.newsbeep.com\/il\/164523\/","title":{"rendered":"Are South Indians at higher risk of heart disease? New inStem study reveals unique genetic signature"},"content":{"rendered":"

The Institute for Stem Cell Science and Regenerative Medicine (inStem) in Bengaluru recently published groundbreaking research in the Journal of the American Heart Association, revealing a unique genetic signature for Hypertrophic Cardiomyopathy (HCM) among people of South Indian origin. <\/p>\n

HCM is a serious condition characterized by the thickening of the heart muscle<\/a>, often leading to heart failure or sudden cardiac death, as reported by Deccan Herald.<\/p>\n

Core discovery<\/p>\n

The study, which performed detailed genetic analysis on a cohort of 335 primary HCM patients from South India, found that the genetic landscape of this population is markedly different from that seen in European and American cohorts.<\/p>\n

Fewer Common Mutations: The South Indian patients exhibited significantly fewer mutations in the two genes most commonly associated with HCM globally – (MYBPC3 and MYH7).<\/p>\n

Increased Variation in Other Genes: Indian patients showed a greater variation in other genes including Mi Hb, which were previously considered less important.<\/p>\n

Dr Perundurai S Dhandapany, Associate Professor at BRIC-inStem and the corresponding author of the paper, said: \u201cIt opens the door to study other genetic conditions where Indians have unique genetic signatures and enables a better, inclusive screening programme for sudden cardiac deaths<\/a>.\u201d<\/p>\n

Research implications<\/p>\n

This unexpected genetic profile challenges long-held, Western-centric assumptions about HCM aetiology and has profound implications for the future of cardiac care in India.<\/p>\n

The findings underscore the critical importance of conducting cardiovascular medicine research tailored to India’s diverse populations, moving away from reliance on global, non-Indian genetic data.<\/p>\n

Diagnosis and risk stratification<\/p>\n

By understanding these unique mutations, clinicians can more accurately diagnose the risk for sudden cardiac events, allowing for more precise treatment and prophylactic measures.<\/p>\n

The discovery emphasizes the urgent need for comprehensive genetic screening, particularly for young adults, who may be at risk for sudden cardiac death due to these regional genetic variations.<\/p>\n

This research is poised to be a game-changer for personalized medicine in India, paving the way for targeted diagnostic tools and treatments based on ethnicity-specific genetic markers.<\/p>\n

By identifying these unique genetic mutations, clinicians can now develop targeted diagnostic tests and treatments for South Indian patients, leading to earlier detection and better clinical outcomes, said Dr Perundurai S Dhandapany.<\/p>\n","protected":false},"excerpt":{"rendered":"The Institute for Stem Cell Science and Regenerative Medicine (inStem) in Bengaluru recently published groundbreaking research in the…\n","protected":false},"author":2,"featured_media":164524,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[10],"tags":[40078,163,3549,823,48338,85,98512,46,98511],"class_list":{"0":"post-164523","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-health","8":"tag-cardiac-arrest","9":"tag-health","10":"tag-heart-attack","11":"tag-heart-disease","12":"tag-hypertrophic-cardiomyopathy","13":"tag-il","14":"tag-instem","15":"tag-israel","16":"tag-south-indias"},"_links":{"self":[{"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/posts\/164523","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/comments?post=164523"}],"version-history":[{"count":0,"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/posts\/164523\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/media\/164524"}],"wp:attachment":[{"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/media?parent=164523"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/categories?post=164523"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/tags?post=164523"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}