{"id":193090,"date":"2025-12-19T13:07:09","date_gmt":"2025-12-19T13:07:09","guid":{"rendered":"https:\/\/www.newsbeep.com\/il\/193090\/"},"modified":"2025-12-19T13:07:09","modified_gmt":"2025-12-19T13:07:09","slug":"xenosiderophore-transporter-gene-expression-and-clade-specific-filamentation-in-candida-auris-killifish-aphanius-dispar-infection","status":"publish","type":"post","link":"https:\/\/www.newsbeep.com\/il\/193090\/","title":{"rendered":"Xenosiderophore transporter gene expression and clade-specific filamentation in Candida auris killifish (Aphanius dispar) infection"},"content":{"rendered":"

Meis, J. F. & Chowdhary, A. Candida auris: a global fungal public health threat. Lancet Infect. Dis. 18, 1298\u20131299 (2018).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

WHO. World Health Organization (WHO) fungal priority pathogens list to guide research, development and public health action. https:\/\/www.who.int\/publications\/i\/item\/9789240060241<\/a> (2022).<\/p>\n

Lee, W. G. et al. First three reported cases of nosocomial fungemia caused by Candida auris. J. Clin. Microbiol. 49, 4 (2011).<\/p>\n

Article<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Satoh, K. et al. Candida auris sp. Nov., a novel ascomycetous yeast isolated from the external ear canal of an inpatient in a Japanese hospital. Microbiol. Immunol. 53, 41\u201344 (2009).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Eyre, D. W. et al. A Candida auris outbreak and its control in an intensive care setting. N. Engl. J. Med. 379, 1322\u20131331 (2018).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Taori, S. K. et al. Candida auris outbreak: mortality, interventions and cost of sustaining control. J. Infect. 79, 601\u2013611 (2019).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Shuping, L. et al. High prevalence of Candida auris colonization during protracted neonatal unit outbreak, South Africa. Emerg. Infect. Dis. https:\/\/doi.org\/10.3201\/eid2909.230393<\/a> (2023).<\/p>\n

Adam, R. D. et al. Analysis of Candida auris fungemia at a single facility in Kenya. Int. J. Infect. Dis. 85, 182\u2013187 (2019).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Prayag, P. S., Patwardhan, S., Panchakshari, S., Rajhans, P. A. & Prayag, A. The dominance of Candida auris: a single-center experience of 79 episodes of candidemia from western India. Indian J. Crit. Care Med. 26, 560\u2013563 (2022).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Chen, J. et al. Is the superbug fungus really so scary? A systematic review and meta-analysis of global epidemiology and mortality of Candida auris. BMC Infect. Dis. 20, 827 (2020).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Lyman, M. Notes from the field: transmission of pan-resistant and echinocandin-resistant Candida auris in health care facilities\u2014Texas and the District of Columbia, January-April 2021. Morb. Mortal. Wkly. Rep. 70, 1022\u20131023 (2021).<\/p>\n

Khan, T. et al. Emergence of the novel sixth Candida auris clade VI in Bangladesh. Microbiol. Spectr. 12, e03540\u201323 (2024).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Suphavilai, C. et al. Detection and characterisation of a sixth Candida auris clade in Singapore: a genomic and phenotypic study. Lancet Microbe 5, 100878 (2024).<\/p>\n

Lockhart, S. R. et al. Simultaneous emergence of multidrug-resistant Candida auris on 3 continents confirmed by whole-genome sequencing and epidemiological analyses. Clin. Infect. Dis. 64, 134\u2013140 (2017).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Gifford, H., Rhodes, J. & Farrer, R. A. The diverse genomes of Candida auris. Lancet Microbe 5, 100903 (2024).<\/p>\n

Byun, S. A. et al. Virulence traits and azole resistance in Korean Candida auris Isolates. J. Fungi 9, 979 (2023).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Santana, D. J., Zhao, G. & O\u2019Meara, T. R. The many faces of Candida auris: phenotypic and strain variation in an emerging pathogen. PLoS Pathog. 20, e1012011 (2024).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Wang, T. W. et al. Functional redundancy in Candida auris cell surface adhesins crucial for cell-cell interaction and aggregation. Nat. Commun. 15, 9212 (2024).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Allert, S. et al. From environmental adaptation to host survival: attributes that mediate pathogenicity of Candida auris. Virulence 13, 191\u2013214 (2022).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Fayed, B. et al. Transcriptome analysis of human dermal cells infected with Candida auris identified unique pathogenesis\/defensive mechanisms particularly ferroptosis. Mycopathologia 189, 65 (2024).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Yang, B. et al. A correlative study of the genomic underpinning of virulence traits and drug tolerance of Candida auris. Infect. Immun. 0, e00103\u2013e00124 (2024).<\/p>\n


\n Google Scholar<\/a>\u00a0\n <\/p>\n

Balakumar, A. et al. Single-cell transcriptomics unveils skin cell specific antifungal immune responses and IL-1Ra- IL-1R immune evasion strategies of emerging fungal pathogen Candida auris. PLoS Pathog. 20, e1012699 (2024).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Bruno, M. et al. Transcriptional and functional insights into the host immune response against the emerging fungal pathogen Candida auris. Nat. Microbiol. 5, 1516\u20131531 (2020).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Wang, Y. et al. Innate immune responses against the fungal pathogen Candida auris. Nat. Commun. 13, 3553 (2022).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Yue, H. et al. Filamentation in Candida auris, an emerging fungal pathogen of humans: passage through the mammalian body induces a heritable phenotypic switch. Emerg. Microbes Infect. 7, 1\u201313 (2018).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Chadwick, C., Jesus, M. D., Ginty, F. & Martinez, J. S. Pathobiology of Candida auris infection analyzed by multiplexed imaging and single cell analysis. PLoS ONE 19, e0293011 (2024).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Santana, D. J. et al. A Candida auris-specific adhesin, Scf1, governs surface association, colonization, and virulence. Science 381, 1461\u20131467 (2023).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Pelletier, C., Shaw, S., Alsayegh, S., Brown, A. J. P. & Lorenz, A. Candida auris undergoes adhesin-dependent and -independent cellular aggregation. PLoS Pathog. 20, e1012076 (2024).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Mu\u00f1oz, J. F. et al. Genomic insights into multidrug-resistance, mating and virulence in Candida auris and related emerging species. Nat. Commun. 9, 5346 (2018).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Richardson, J. P. et al. Candidalysins are a new family of cytolytic fungal peptide toxins. mBio 13, e03510\u2013e03521 (2022).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Kim, J.-S., Lee, K.-T. & Bahn, Y.-S. Secreted aspartyl protease 3 regulated by the Ras\/cAMP\/PKA pathway promotes the virulence of Candida auris. Front. Cell. Infect. Microbiol. 13, 1257897 (2023).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Horton, M. V. et al. Candida auris cell wall mannosylation contributes to neutrophil evasion through pathways divergent from Candida albicans and Candida glabrata. mSphere 6, e00406\u2013e00421 (2021).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Weerasinghe, H. et al. Candida auris uses metabolic strategies to escape and kill macrophages while avoiding robust activation of the NLRP3 inflammasome response. Cell Rep. 42, 112522 (2023).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Wang, X. et al. The first isolate of Candida auris in China: clinical and biological aspects. Emerg. Microbes Infect. 7, 1\u20139 (2018).<\/p>\n

Article<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Fan, S., Li, C., Bing, J., Huang, G. & Du, H. Discovery of the diploid form of the emerging fungal pathogen Candida auris. ACS Infect. Dis. 6, 2641\u20132646 (2020).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Fan, S. et al. A biological and genomic comparison of a drug-resistant and a drug-susceptible strain of Candida auris isolated from Beijing, China. Virulence 12, 1388\u20131399 (2021).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Wurster, S., Albert, N. D. & Kontoyiannis, D. P. Candida auris bloodstream infection induces upregulation of the PD-1\/PD-L1 immune checkpoint pathway in an immunocompetent mouse model. mSphere 7, e00817\u2013e00821 (2022).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Bing, J. et al. Rapid evolution of an adaptive multicellular morphology of Candida auris during systemic infection. Nat. Commun. 15, 2381 (2024).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Ben-Ami, R. et al. Multidrug-resistant Candida haemulonii and C. auris, Tel Aviv, Israel. Emerg. Infect. Dis. 23, 195\u2013203 (2017).<\/p>\n

Hager, C. L., Larkin, E. L., Long, L. A. & Ghannoum, M. A. Evaluation of the efficacy of rezafungin, a novel echinocandin, in the treatment of disseminated Candida auris infection using an immunocompromised mouse model. J. Antimicrobial. Chemother. 73, 2085\u20132088 (2018).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Zhao, M. et al. In vivo pharmacokinetics and pharmacodynamics of APX001 against Candida spp. In a neutropenic disseminated candidiasis mouse model. Antimicrobial. Agents Chemother. 62, e02542\u201317 (2018).<\/p>\n

CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Singh, S. et al. The NDV-3A vaccine protects mice from multidrug resistant Candida auris infection. PLoS Pathog. 15, e1007460 (2019).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Zhang, F. et al. A marine microbiome antifungal targets urgent-threat drug-resistant fungi. Science 370, 974\u2013978 (2020).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Mu\u00f1oz, J. E. et al. Pathogenicity levels of Colombian strains of Candida auris and Brazilian strains of Candida haemulonii species complex in both murine and Galleria mellonella experimental models. J. Fungi 6, 104 (2020).<\/p>\n

Article<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Abe, M. et al. Potency of gastrointestinal colonization and virulence of Candida auris in a murine endogenous candidiasis. PLoS ONE 15, e0243223 (2020).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Forg\u00e1cs, L. et al. Comparison of in vivo pathogenicity of four Candida auris clades in a neutropenic bloodstream infection murine model. Emerg. Microbes Infect. 9, 1160\u20131169 (2020).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Nagy, F. et al. In vitro and in vivo interaction of caspofungin with isavuconazole against Candida auris planktonic cells and biofilms. Med. Mycol. 59, 1015\u20131023 (2021).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Forg\u00e1cs, L. et al. In vivo efficacy of amphotericin B against four Candida auris clades. J. Fungi 8, 499 (2022).<\/p>\n

Article<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Singh, S. et al. Protective efficacy of anti-Hyr1p monoclonal antibody against systemic candidiasis due to multi-drug-resistant Candida auris. J. Fungi 9, 103 (2023).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Salama, E. A. et al. Lansoprazole interferes with fungal respiration and acts synergistically with amphotericin B against multidrug-resistant Candida auris. Emerg. Microbes Infect. 13, 2322649 (2024).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Torres, S. R. et al. Impact of Candida auris infection in a neutropenic murine model. Antimicrobial. Agents Chemother. 64, e01625\u201319 (2020).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Xin, H., Mohiuddin, F., Tran, J., Adams, A. & Eberle, K. Experimental mouse models of disseminated Candida auris infection. mSphere 4, e00339\u201319 (2019).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Rosario-Colon, J., Eberle, K., Adams, A., Courville, E. & Xin, H. Candida cell-surface-specific monoclonal antibodies protect mice against Candida auris invasive infection. Int. J. Mol. Sci. 22, 6162 (2021).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Torres, S. R. et al. Assessment of environmental and occupational exposure while working with multidrug resistant (MDR) fungus Candida auris in an animal facility. J. Occup. Environ. Hyg. 16, 507\u2013518 (2019).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Borman, A. M. Of mice and men and larvae: Galleria mellonella to model the early host-pathogen interactions after fungal infection. Virulence 9, 9\u201312 (2017).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Romera, D. et al. The Galleria mellonella infection model as a system to investigate the virulence of Candida auris strains. Pathog. Dis. 78, ftaa067 (2020).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Garc\u00eda-Carnero, L. C. et al. Early virulence predictors during the Candida species\u2013Galleria mellonella interaction. J. Fungi 6, 152 (2020).<\/p>\n

Article<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Garcia-Bustos, V. et al. Characterization of the differential pathogenicity of Candida auris in a Galleria mellonella infection model. Microbiol. Spectr. 9, e00013\u2013e00021 (2021).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Carvajal, S. K. et al. Pathogenicity assessment of Colombian strains of Candida auris in the Galleria mellonella invertebrate model. J. Fungi 7, 401 (2021).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Hernando-Ortiz, A. et al. Virulence of Candida auris from different clinical origins in Caenorhabditis elegans and Galleria mellonella host models. Virulence 12, 1063\u20131075 (2021).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Spettel, K. et al. Candida auris in Austria\u2014what is new and what is different. J. Fungi 9, 129 (2023).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Wurster, S. et al. Drosophila melanogaster as a model to study virulence and azole treatment of the emerging pathogen Candida auris. J. Antimicrobial. Chemother. 74, 1904\u20131910 (2019).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Harpf, V., Rambach, G., W\u00fcrzner, R., Lass-Fl\u00f6rl, C. & Speth, C. Candida and complement: new aspects in an old battle. Front. Immunol. 11, 1471 (2020).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Pechacek, J. & Lionakis, M. S. Host defense mechanisms against Candida auris. Expert Rev. Anti Infec. Ther. 21, 1087\u20131096 (2023).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Johnson, C. J., Davis, J. M., Huttenlocher, A., Kernien, J. F. & Nett, J. E. Emerging fungal pathogen Candida auris evades neutrophil attack. mBio 9, e01403\u2013e01418 (2018).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Pharkjaksu, S., Boonmee, N., Mitrpant, C. & Ngamskulrungroj, P. Immunopathogenesis of emerging Candida auris and Candida haemulonii strains. J. Fungi 7, 725 (2021).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Shapiro, R. S. & Cowen, L. E. Uncovering cellular circuitry controlling temperature-dependent fungal morphogenesis. Virulence 3, 400\u2013404 (2012).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Leach, M. D. et al. Hsf1 and Hsp90 orchestrate temperature-dependent global transcriptional remodelling and chromatin architecture in Candida albicans. Nat. Commun. 7, 11704 (2016).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Xiao, W. et al. Response and regulatory mechanisms of heat resistance in pathogenic fungi. Appl. Microbiol. Biotechnol. 106, 5415\u20135431 (2022).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Arora, P. et al. Environmental isolation of Candida auris from the coastal wetlands of Andaman Islands, India. mBio 12, e03181\u201320 (2021).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Escand\u00f3n, P. Novel environmental niches for Candida auris: isolation from a coastal habitat in Colombia. J. Fungi 8, 748 (2022).<\/p>\n

Article<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Uden, V. & Kolipinski, M. C. Torulopsis haemulonii nov. spec., a yeast from the Atlantic Ocean. Antonie Van. Leeuwenhoek 28, 78\u201380 (1962).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Bavia, L., Santiesteban-Lores, L. E., Carneiro, M. C. & Prodocimo, M. M. Advances in the complement system of a teleost fish, Oreochromis niloticus. Fish. Shellfish Immunol. 123, 61\u201374 (2022).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Buchmann, K., Karami, A. M. & Duan, Y. The early ontogenetic development of immune cells and organs in teleosts. Fish. Shellfish Immunol. 146, 109371 (2024).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Tian, H. et al. Cytokine networks provide sufficient evidence for the differentiation of CD4+ T cells in teleost fish. Dev. Comp. Immunol. 141, 104627 (2023).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Akbarzadeh, A. & Leder, E. H. Acclimation of killifish to thermal extremes of hot spring: transcription of gonadal and liver heat shock genes. Comp. Biochem. Physiol. Part A Mol. Integr. Physiol. 191, 89\u201397 (2016).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Hamied, A. et al. Identification and characterization of highly fluorescent pigment cells in embryos of the Arabian killifish (Aphanius Dispar). iScience 23, 101674 (2020).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Alsakran, A. et al. Stage-by-stage exploration of normal embryonic development in the Arabian killifish. Aphanius dispar. Dev. Dyn. 254, 380\u2013395 (2024).<\/p>\n

Minhas, R. et al. The thermotolerant Arabian killifish, Aphanius dispar, as a novel infection model for human fungal pathogens. https:\/\/doi.org\/10.1101\/2024.10.08.617174<\/a> (2024).<\/p>\n

Gifford, H., Wilson, D., Rhodes, J. & Farrer, R. A. Seaside to bedside: assembly in research for emerging human fungal pathogen Candida auris. In Genome Assembly (ed. Farrer, R. A.) vol. 2955 263\u2013291 (Springer US, 2025).<\/p>\n

Burden, N., Chapman, K., Sewell, F. & Robinson, V. Pioneering better science through the 3Rs: an introduction to the national centre for the replacement, refinement, and reduction of animals in research (NC3Rs). J. Am. Assoc. Lab. Anim. Sci. 54, 198\u2013208 (2015).<\/p>\n

PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Skrzypek, M. S. et al. The Candida Genome Database (CGD): incorporation of assembly 22, systematic identifiers and visualization of high throughput sequencing data. Nucleic Acids Res. 45, D592\u2013D596 (2017).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Potrykus, J. et al. Fungal iron availability during deep seated candidiasis is defined by a complex interplay involving systemic and local events. PLoS Pathog. 9, e1003676 (2013).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Kasper, L. et al. The fungal peptide toxin candidalysin activates the NLRP3 inflammasome and causes cytolysis in mononuclear phagocytes. Nat. Commun. 9, 4260 (2018).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Bonzi, L. C. et al. The time course of molecular acclimation to seawater in a euryhaline fish. Sci. Rep. 11, 18127 (2021).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Varma, A. et al. Molecular cloning and functional characterisation of a glucose transporter, CaHGT1, of Candida albicans. FEMS Microbiol. Lett. 182, 15\u201321 (2000).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Luo, L., Tong, X. & Farley, P. C. The Candida albicans gene HGT12 (Orf19.7094) encodes a hexose transporter. FEMS Immunol. Med. Microbiol. 51, 14\u201317 (2007).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Brown, V., Sexton, J. A. & Johnston, M. A glucose sensor in Candida albicans. Eukaryot. Cell 5, 1726\u20131737 (2006).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Larcombe, D. E. et al. Glucose-enhanced oxidative stress resistance-A protective anticipatory response that enhances the fitness of Candida albicans during systemic infection. PLoS Pathog. 19, e1011505 (2023).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Martin, R. et al. A core filamentation response network in Candida albicans is restricted to eight genes. PLoS ONE 8, e58613 (2013).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Schatzman, S. S. et al. Copper-only superoxide dismutase enzymes and iron starvation stress in Candida fungal pathogens. J. Biol. Chem. 295, 570\u2013583 (2020).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Rybak, J. M. et al. Abrogation of triazole resistance upon deletion of CDR1 in a clinical isolate of Candida auris. Antimicrob. Agents and Chemother. 63, e00057\u201319 (2019).<\/p>\n

Li, J., Coste, A. T., Bachmann, D., Sanglard, D. & Lamoth, F. Deciphering the Mrr1\/Mdr1 pathway in azole resistance of Candida auris. Antimicrobial. Agents Chemother. 66, e00067\u201322 (2022).<\/p>\n

Article<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Sun, S., Coelho, M. A., David-Palma, M., Priest, S. J. & Heitman, J. The evolution of sexual reproduction and the mating-type locus: links to pathogenesis of Cryptococcus human pathogenic fungi. Annu. Rev. Genet. 53, 417\u2013444 (2019).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Wang, Y. & Xu, J. Population genomic analyses reveal evidence for limited recombination in the superbug Candida auris in nature. Comput. Struct. Biotechnol. J. 20, 3030\u20133040 (2022).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Chow, N. A. et al. Potential fifth clade of Candida auris, Iran, 2018. Emerg. Infect. Dis. 25, 1780\u20131781 (2019).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Louvet, M. et al. Ume6-dependent pathways of morphogenesis and biofilm formation in Candida auris. Microbiol. Spectr. 0, e01531\u201324 (2024).<\/p>\n


\n Google Scholar<\/a>\u00a0\n <\/p>\n

Deng, Y., Li, S., Bing, J., Liao, W. & Tao, L. Phenotypic switching and filamentation in Candida haemulonii, an emerging opportunistic pathogen of humans. Microbiol. Spectr. 9, e00779\u201321 (2021).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Overy, D. P., R\u00e4m\u00e4, T., Oosterhuis, R., Walker, A. K. & Pang, K.-L. The neglected marine fungi, Sensu stricto, and their isolation for natural products\u2019 discovery. Mar. Drugs 17, 42 (2019).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Seiser, S. et al. Native human and mouse skin infection models to study Candida auris-host interactions. Microbes Infect. 26, 105234 (2024).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Fan, S. et al. Filamentous growth is a general feature of Candida auris clinical isolates. Med. Mycol. 59, 734\u2013740 (2021).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Bravo Ruiz, G., Ross, Z. K., Gow, N. A. R. & Lorenz, A. Pseudohyphal growth of the emerging pathogen Candida auris is triggered by genotoxic stress through the S phase checkpoint. mSphere 5, e00151\u201320 (2020).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Kim, S. H. et al. Genetic analysis of Candida auris implicates Hsp90 in morphogenesis and azole tolerance and Cdr1 in Azole Resistance. mBio 10, e02529\u201318 (2019).<\/p>\n

CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Gao, J. et al. LncRNA DINOR is a virulence factor and global regulator of stress responses in Candida auris. Nat. Microbiol. 6, 842\u2013851 (2021).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Chybowska, A. D., Childers, D. S. & Farrer, R. A. Nine things genomics can tell us about Candida auris. Front. Genet. 11, 351 (2020).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Ismail, A., Bedell, G. W. & Lupan, D. M. Siderophore production by the pathogenic yeast, Candida albicans. Biochem. Biophys. Res. Commun. 130, 885\u2013891 (1985).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Heymann, P. et al. The Siderophore iron transporter of Candida albicans (Sit1p\/Arn1p) mediates uptake of ferrichrome-type siderophores and Is required for epithelial invasion. Infect. Immun. 70, 5246\u20135255 (2002).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Boiteau, R. M. et al. Siderophore-based microbial adaptations to iron scarcity across the eastern Pacific Ocean. Proc. Natl. Acad. Sci. USA 113, 14237\u201314242 (2016).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Park, J. et al. Siderophore production and utilization by marine bacteria in the North Pacific Ocean. Limnol. Oceanogr. 68, 1636\u20131653 (2023).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Renshaw, J. C. et al. Fungal siderophores: structures, functions and applications. Mycol. Res. 106, 1123\u20131142 (2002).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Johnstone, T. C. & Nolan, E. M. Beyond iron: non-classical biological functions of bacterial siderophores. Dalton Trans. 44, 6320\u20136339 (2015).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Nakajima, Y. et al. Effect of disrupting the trichothecene efflux pump encoded by FgTri12 in the nivalenol chemotype of Fusarium graminearum. J. Gen. Appl. Microbiol. 61, 93\u201396 (2015).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Xue, P. et al. Heme sensing and trafficking in fungi. Fungal Biol. Rev. 43, 100286 (2023).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Fourie, R., Kuloyo, O. O., Mochochoko, B. M., Albertyn, J. & Pohl, C. H. Iron at the Centre of Candida albicans Interactions. Front. Cell. Infect. Microbiol. 8, 185 (2018).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Alselami, A. & Drummond, R. A. How metals fuel fungal virulence, yet promote anti-fungal immunity. Dis. Models Mech. 16, dmm050393 (2023).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Pradhan, A. et al. Non-canonical signalling mediates changes in fungal cell wall PAMPs that drive immune evasion. Nat. Commun. 10, 5315 (2019).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Weissman, Z. & Kornitzer, D. A family of Candida cell surface haem-binding proteins involved in haemin and haemoglobin-iron utilization. Mol. Microbiol. 53, 1209\u20131220 (2004).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Ding, C. et al. Conserved and divergent roles of Bcr1 and CFEM proteins in Candida parapsilosis and Candida albicans. PLoS ONE 6, e28151 (2011).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Sharma, P. & Pasrija, R. Iron chelators enhance the potency of Echinocandins against Candida auris. https:\/\/doi.org\/10.21203\/rs.3.rs-7042978\/v1<\/a> (2025).<\/p>\n

Simm, C. et al. Disruption of iron homeostasis and mitochondrial metabolism are promising targets to inhibit Candida auris. Microbiol. Spectr. 10, e00100\u2013e00122 (2022).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Zhang, J. et al. Pyrvinium pamoate synergizes with azoles in vitro and in vivo to exert antifungal efficacy against Candida auris and other Candida species. Infect. Drug Resist. 18, 783\u2013789 (2025).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Hoyer, L. L., Green, C. B., Oh, S.-H. & Zhao, X. Discovering the secrets of the Candida albicans agglutinin-like sequence (ALS) gene family\u2014a sticky pursuit. Med. Mycol. 46, 1\u201315 (2008).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Smoak, R. A., Snyder, L. F., Fassler, J. S. & He, B. Z. Parallel expansion and divergence of an adhesin family in pathogenic yeasts. Genetics 223, iyad024 (2023).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Sert, N. P. du et al. Reporting animal research: explanation and elaboration for the ARRIVE guidelines 2.0. PLoS Biol. 18, e3000411 (2020).<\/p>\n

Benjamini, Y. & Hochberg, Y. Controlling the false discovery rate: a practical and powerful approach to multiple testing. J. R. Stat. Soc. Ser. B Stat. Methodol. 57, 289\u2013300 (1995).<\/p>\n

Article<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Suvarna, S. K., Layton, C. & Bancroft, J. D. In Bancroft\u2019s Theory and Practice of Histological Techniques (Churchill Livingstone Elsevier, 2013).<\/p>\n

Chen, S., Zhou, Y., Chen, Y. & Gu, J. Fastp: an ultra-fast all-in-one FASTQ preprocessor. Bioinformatics 34, i884\u2013i890 (2018).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Ewels, P., Magnusson, M., Lundin, S. & K\u00e4ller, M. MultiQC: summarize analysis results for multiple tools and samples in a single report. Bioinformatics 32, 3047\u20133048 (2016).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Haas, B. J. et al. De novo transcript sequence reconstruction from RNA-seq using the Trinity platform for reference generation and analysis. Nat. Protoc. 8, 1494\u20131512 (2013).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Abastabar, M. et al. Candida auris otomycosis in Iran and review of recent literature. Mycoses 62, 101\u2013105 (2019).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Mu\u00f1oz, J. F. et al. Clade-specific chromosomal rearrangements and loss of subtelomeric adhesins in Candida auris. Genetics 218, iyab029 (2021).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Langmead, B. & Salzberg, S. L. Fast gapped-read alignment with Bowtie 2. Nat. Methods 9, 357\u2013359 (2012).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Li, B. & Dewey, C. N. RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome. BMC Bioinforma. 12, 323 (2011).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Robinson, M. D., McCarthy, D. J. & Smyth, G. K. edgeR: a Bioconductor package for differential expression analysis of digital gene expression data. Bioinformatics 26, 139\u2013140 (2010).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Li, H. et al. The sequence alignment\/map format and SAMtools. Bioinformatics 25, 2078\u20132079 (2009).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Ritchie, M. E. et al. Limma powers differential expression analyses for RNA-sequencing and microarray studies. Nucleic Acids Res. 43, e47 (2015).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Gu, Z., Eils, R. & Schlesner, M. Complex heatmaps reveal patterns and correlations in multidimensional genomic data. Bioinformatics 32, 2847\u20132849 (2016).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Ashburner, M. et al. Gene ontology: tool for the unification of biology. Nat. Genet. 25, 25\u201329 (2000).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

The Gene Ontology Consortium et al. The Gene Ontology knowledgebase in 2023. Genetics 224, iyad031 (2023).<\/p>\n

Article<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Buchfink, B., Reuter, K. & Drost, H.-G. Sensitive protein alignments at tree-of-life scale using DIAMOND. Nat. Methods 18, 366\u2013368 (2021).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Golden, C., Studholme, D. J. & Farrer, R. A. DIAMOND2GO: a rapid Gene Ontology assignment and enrichment tool for functional genomics. https:\/\/doi.org\/10.1101\/2024.08.19.608700<\/a> (2024).<\/p>\n

Kanehisa, M., Furumichi, M., Sato, Y., Kawashima, M. & Ishiguro-Watanabe, M. KEGG for taxonomy-based analysis of pathways and genomes. Nucleic Acids Res. 51, D587\u2013D592 (2022).<\/p>\n

Article<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Kanehisa, M., Sato, Y. & Morishima, K. BlastKOALA and GhostKOALA: KEGG tools for functional characterization of genome and metagenome sequences. J. Mol. Biol. 428, 726\u2013731 (2016).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Bateman, A. et al. The Pfam protein families database. Nucleic Acids Res. 32, D138\u2013D141 (2004).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Eddy, S. R. Accelerated profile HMM searches. PLoS Comput. Biol. 7, e1002195 (2011).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Almagro Armenteros, J. J. et al. SignalP 5.0 improves signal peptide predictions using deep neural networks. Nat. Biotechnol. 37, 420\u2013423 (2019).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Hallgren, J. et al. DeepTMHMM predicts alpha and beta transmembrane proteins using deep neural networks. https:\/\/doi.org\/10.1101\/2022.04.08.487609<\/a> (2022).<\/p>\n

G\u00edslason, M. H., Nielsen, H., Almagro Armenteros, J. J. & Johansen, A. R. Prediction of GPI-anchored proteins with pointer neural networks. Curr. Res. Biotechnol. 3, 6\u201313 (2021).<\/p>\n

Article<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Camacho, C. et al. BLAST+: architecture and applications. BMC Bioinforma. 10, 421 (2009).<\/p>\n

Article<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Supek, F., Bo\u0161njak, M., \u0160kunca, N. & \u0160muc, T. REVIGO summarizes and visualizes long lists of gene ontology terms. PLoS ONE 6, e21800 (2011).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Farrer, R. A. Synima: a synteny imaging tool for annotated genome assemblies. BMC Bioinforma. 18, 507 (2017).<\/p>\n

Article<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Emms, D. M. & Kelly, S. OrthoFinder: phylogenetic orthology inference for comparative genomics. Genome Biol. 20, 238 (2019).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Edgar, R. C. MUSCLE: Multiple sequence alignment with high accuracy and high throughput. Nucleic Acids Res. 32, 1792\u20131797 (2004).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Price, M. N., Dehal, P. S. & Arkin, A. P. FastTree 2 \u2013 approximately maximum-likelihood trees for large alignments. PLoS ONE 5, e9490 (2010).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Abramson, J. et al. Accurate structure prediction of biomolecular interactions with AlphaFold 3. Nature 630, 493\u2013500 (2024).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Pettersen, E. F. et al. UCSF ChimeraX: structure visualization for researchers, educators, and developers. Protein Sci. 30, 70\u201382 (2021).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Stamatakis, A. RAxML version 8: a tool for phylogenetic analysis and post-analysis of large phylogenies. Bioinformatics 30, 1312\u20131313 (2014).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Sievers, F. & Higgins, D. G. Clustal Omega. Curr. Protoc. Bioinforma. 48, 3.13.1\u20133.13.16 (2014).<\/p>\n

Article<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Gifford, H. et al. Hughgifford\/Arabian_Killifish_C_auris_2024: Pre-publication. https:\/\/zenodo.org\/records\/17515669<\/a> (2025).<\/p>\n","protected":false},"excerpt":{"rendered":"Meis, J. F. & Chowdhary, A. Candida auris: a global fungal public health threat. Lancet Infect. Dis. 18,…\n","protected":false},"author":2,"featured_media":193091,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[10],"tags":[110235,110236,110237,3181,163,85,46,3183],"class_list":{"0":"post-193090","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-health","8":"tag-fungal-genomics","9":"tag-fungal-host-response","10":"tag-fungal-pathogenesis","11":"tag-general","12":"tag-health","13":"tag-il","14":"tag-israel","15":"tag-life-sciences"},"_links":{"self":[{"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/posts\/193090","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/comments?post=193090"}],"version-history":[{"count":0,"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/posts\/193090\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/media\/193091"}],"wp:attachment":[{"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/media?parent=193090"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/categories?post=193090"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/tags?post=193090"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}