{"id":256118,"date":"2026-01-25T00:09:24","date_gmt":"2026-01-25T00:09:24","guid":{"rendered":"https:\/\/www.newsbeep.com\/il\/256118\/"},"modified":"2026-01-25T00:09:24","modified_gmt":"2026-01-25T00:09:24","slug":"dietary-fiber-deficiency-exacerbates-intestinal-inflammation-via-mir-6240-enriched-gut-extracellular-vesicles","status":"publish","type":"post","link":"https:\/\/www.newsbeep.com\/il\/256118\/","title":{"rendered":"Dietary fiber deficiency exacerbates intestinal inflammation via miR-6240-enriched gut extracellular vesicles"},"content":{"rendered":"<p class=\"c-article-references__text\" id=\"ref-CR1\">Magro, D. O., Sassaki, L. Y. &amp; Chebli, J. M. F. Interaction between diet and genetics in patients with inflammatory bowel disease. World J. Gastroenterol. 30, 1644\u20131650 (2024).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 1\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Interaction%20between%20diet%20and%20genetics%20in%20patients%20with%20inflammatory%20bowel%20disease&amp;journal=World%20J.%20Gastroenterol.&amp;volume=30&amp;pages=1644-1650&amp;publication_year=2024&amp;author=Magro%2CDO&amp;author=Sassaki%2CLY&amp;author=Chebli%2CJMF\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR2\">Deehan, E. C. &amp; Walter, J. The fiber gap and the disappearing gut microbiome: Implications for human nutrition. Trends Endocrinol. Metab. 27, 239\u2013242 (2016).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 2\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=The%20fiber%20gap%20and%20the%20disappearing%20gut%20microbiome%3A%20Implications%20for%20human%20nutrition&amp;journal=Trends%20Endocrinol.%20Metab.&amp;volume=27&amp;pages=239-242&amp;publication_year=2016&amp;author=Deehan%2CEC&amp;author=Walter%2CJ\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR3\">Macia, L. et al. Metabolite-sensing receptors GPR43 and GPR109A facilitate dietary fibre-induced gut homeostasis through regulation of the inflammasome. Nat. Commun. 6, 6734 (2015).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 3\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Metabolite-sensing%20receptors%20GPR43%20and%20GPR109A%20facilitate%20dietary%20fibre-induced%20gut%20homeostasis%20through%20regulation%20of%20the%20inflammasome&amp;journal=Nat.%20Commun.&amp;volume=6&amp;publication_year=2015&amp;author=Macia%2CL\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR4\">Tan, J. K., Macia, L. &amp; Mackay, C. R. Dietary fiber and SCFAs in the regulation of mucosal immunity. J. Allergy Clin. Immunol. 151, 361\u2013370 (2023).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 4\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Dietary%20fiber%20and%20SCFAs%20in%20the%20regulation%20of%20mucosal%20immunity&amp;journal=J.%20Allergy%20Clin.%20Immunol.&amp;volume=151&amp;pages=361-370&amp;publication_year=2023&amp;author=Tan%2CJK&amp;author=Macia%2CL&amp;author=Mackay%2CCR\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR5\">Desai, M. S. et al. A dietary fiber-deprived gut microbiota degrades the colonic mucus barrier and enhances pathogen susceptibility. Cell 167, 1339\u20131353 e1321 (2016).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 5\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=A%20dietary%20fiber-deprived%20gut%20microbiota%20degrades%20the%20colonic%20mucus%20barrier%20and%20enhances%20pathogen%20susceptibility&amp;journal=Cell&amp;volume=167&amp;pages=1339-1353%20e1321&amp;publication_year=2016&amp;author=Desai%2CMS\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR6\">Shen, S. et al. Deficiency of dietary fiber modulates gut microbiota composition, neutrophil recruitment and worsens experimental colitis. Front Immunol. 12, 619366 (2021).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 6\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Deficiency%20of%20dietary%20fiber%20modulates%20gut%20microbiota%20composition%2C%20neutrophil%20recruitment%20and%20worsens%20experimental%20colitis&amp;journal=Front%20Immunol.&amp;volume=12&amp;publication_year=2021&amp;author=Shen%2CS\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR7\">David, L. A. et al. Diet rapidly and reproducibly alters the human gut microbiome. Nature 505, 559\u2013563 (2014).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 7\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Diet%20rapidly%20and%20reproducibly%20alters%20the%20human%20gut%20microbiome&amp;journal=Nature&amp;volume=505&amp;pages=559-563&amp;publication_year=2014&amp;author=David%2CLA\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR8\">Pan, B. T. &amp; Johnstone, R. M. Fate of the transferrin receptor during maturation of sheep reticulocytes in vitro: selective externalization of the receptor. Cell 33, 967\u2013978 (1983).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 8\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Fate%20of%20the%20transferrin%20receptor%20during%20maturation%20of%20sheep%20reticulocytes%20in%20vitro%3A%20selective%20externalization%20of%20the%20receptor&amp;journal=Cell&amp;volume=33&amp;pages=967-978&amp;publication_year=1983&amp;author=Pan%2CBT&amp;author=Johnstone%2CRM\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR9\">Diaz-Garrido, N., Badia, J. &amp; Baldoma, L. Microbiota-derived extracellular vesicles in interkingdom communication in the gut. J. Extracell. Vesicles 10, e12161 (2021).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 9\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Microbiota-derived%20extracellular%20vesicles%20in%20interkingdom%20communication%20in%20the%20gut&amp;journal=J.%20Extracell.%20Vesicles&amp;volume=10&amp;publication_year=2021&amp;author=Diaz-Garrido%2CN&amp;author=Badia%2CJ&amp;author=Baldoma%2CL\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR10\">van Niel, G. et al. Intestinal epithelial cells secrete exosome-like vesicles. Gastroenterology 121, 337\u2013349 (2001).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 10\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Intestinal%20epithelial%20cells%20secrete%20exosome-like%20vesicles&amp;journal=Gastroenterology&amp;volume=121&amp;pages=337-349&amp;publication_year=2001&amp;author=Niel%2CG\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR11\">Jiang, L. et al. EpCAM-dependent extracellular vesicles from intestinal epithelial cells maintain intestinal tract immune balance. Nat. Commun. 7, 13045 (2016).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 11\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=EpCAM-dependent%20extracellular%20vesicles%20from%20intestinal%20epithelial%20cells%20maintain%20intestinal%20tract%20immune%20balance&amp;journal=Nat.%20Commun.&amp;volume=7&amp;publication_year=2016&amp;author=Jiang%2CL\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR12\">Leoni, G. et al. Annexin A1-containing extracellular vesicles and polymeric nanoparticles promote epithelial wound repair. J. Clin. Invest 125, 1215\u20131227 (2015).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 12\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Annexin%20A1-containing%20extracellular%20vesicles%20and%20polymeric%20nanoparticles%20promote%20epithelial%20wound%20repair&amp;journal=J.%20Clin.%20Invest&amp;volume=125&amp;pages=1215-1227&amp;publication_year=2015&amp;author=Leoni%2CG\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR13\">Vishnoi, A. &amp; Rani, S. miRNA biogenesis and regulation of diseases: An updated overview. Methods Mol. Biol. 2595, 1\u201312 (2023).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 13\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=miRNA%20biogenesis%20and%20regulation%20of%20diseases%3A%20An%20updated%20overview&amp;journal=Methods%20Mol.%20Biol.&amp;volume=2595&amp;pages=1-12&amp;publication_year=2023&amp;author=Vishnoi%2CA&amp;author=Rani%2CS\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR14\">Wu, Z. et al. Propionic acid driven by the lactobacillus johnsonii culture supernatant alleviates colitis by inhibiting M1 macrophage polarization by modulating the MAPK pathway in mice. J. Agric Food Chem. 71, 14951\u201314966 (2023).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 14\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Propionic%20acid%20driven%20by%20the%20lactobacillus%20johnsonii%20culture%20supernatant%20alleviates%20colitis%20by%20inhibiting%20M1%20macrophage%20polarization%20by%20modulating%20the%20MAPK%20pathway%20in%20mice&amp;journal=J.%20Agric%20Food%20Chem.&amp;volume=71&amp;pages=14951-14966&amp;publication_year=2023&amp;author=Wu%2CZ\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR15\">Liu, B. et al. Critical contributions of protein cargos to the functions of macrophage-derived extracellular vesicles. J. Nanobiotechnol. 21, 352 (2023).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 15\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Critical%20contributions%20of%20protein%20cargos%20to%20the%20functions%20of%20macrophage-derived%20extracellular%20vesicles&amp;journal=J.%20Nanobiotechnol.&amp;volume=21&amp;publication_year=2023&amp;author=Liu%2CB\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR16\">Xu, Y. et al. Crohn\u2019s disease-associated AIEC inhibiting intestinal epithelial cell-derived exosomal let-7b expression regulates macrophage polarization to exacerbate intestinal fibrosis. Gut Microbes 15, 2193115 (2023).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 16\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Crohn%E2%80%99s%20disease-associated%20AIEC%20inhibiting%20intestinal%20epithelial%20cell-derived%20exosomal%20let-7b%20expression%20regulates%20macrophage%20polarization%20to%20exacerbate%20intestinal%20fibrosis&amp;journal=Gut%20Microbes&amp;volume=15&amp;publication_year=2023&amp;author=Xu%2CY\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR17\">Malmuthuge, N. &amp; Guan, L. L. Noncoding RNAs: Regulatory molecules of host-microbiome crosstalk. Trends Microbiol 29, 713\u2013724 (2021).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 17\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Noncoding%20RNAs%3A%20Regulatory%20molecules%20of%20host-microbiome%20crosstalk&amp;journal=Trends%20Microbiol&amp;volume=29&amp;pages=713-724&amp;publication_year=2021&amp;author=Malmuthuge%2CN&amp;author=Guan%2CLL\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR18\">Fardi, F. et al. An interplay between non-coding RNAs and gut microbiota in human health. Diab Res Clin. Pr. 201, 110739 (2023).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 18\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=An%20interplay%20between%20non-coding%20RNAs%20and%20gut%20microbiota%20in%20human%20health&amp;journal=Diab%20Res%20Clin.%20Pr.&amp;volume=201&amp;publication_year=2023&amp;author=Fardi%2CF\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR19\">Shi, H. et al. A fiber-deprived diet causes cognitive impairment and hippocampal microglia-mediated synaptic loss through the gut microbiota and metabolites. Microbiome 9, 223 (2021).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 19\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=A%20fiber-deprived%20diet%20causes%20cognitive%20impairment%20and%20hippocampal%20microglia-mediated%20synaptic%20loss%20through%20the%20gut%20microbiota%20and%20metabolites&amp;journal=Microbiome&amp;volume=9&amp;publication_year=2021&amp;author=Shi%2CH\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR20\">Gomez-Arango, L. F. et al. Low dietary fiber intake increases Collinsella abundance in the gut microbiota of overweight and obese pregnant women. Gut Microbes 9, 189\u2013201 (2018).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 20\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Low%20dietary%20fiber%20intake%20increases%20Collinsella%20abundance%20in%20the%20gut%20microbiota%20of%20overweight%20and%20obese%20pregnant%20women&amp;journal=Gut%20Microbes&amp;volume=9&amp;pages=189-201&amp;publication_year=2018&amp;author=Gomez-Arango%2CLF\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR21\">Wang, Z. et al. Xylan alleviates dietary fiber deprivation-induced dysbiosis by selectively promoting Bifidobacterium pseudocatenulatum in pigs. Microbiome 9, 227 (2021).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 21\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Xylan%20alleviates%20dietary%20fiber%20deprivation-induced%20dysbiosis%20by%20selectively%20promoting%20Bifidobacterium%20pseudocatenulatum%20in%20pigs&amp;journal=Microbiome&amp;volume=9&amp;publication_year=2021&amp;author=Wang%2CZ\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR22\">Zhang, Y., Song, M., Fan, J., Guo, X. &amp; Tao, S. Impact of probiotics-derived extracellular vesicles on livestock gut barrier function. J. Anim. Sci. Biotechnol. 15, 149 (2024).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 22\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Impact%20of%20probiotics-derived%20extracellular%20vesicles%20on%20livestock%20gut%20barrier%20function&amp;journal=J.%20Anim.%20Sci.%20Biotechnol.&amp;volume=15&amp;publication_year=2024&amp;author=Zhang%2CY&amp;author=Song%2CM&amp;author=Fan%2CJ&amp;author=Guo%2CX&amp;author=Tao%2CS\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR23\">Kim, J. H., Lee, J., Park, J. &amp; Gho, Y. S. Gram-negative and gram-positive bacterial extracellular vesicles. Semin Cell Dev. Biol. 40, 97\u2013104 (2015).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 23\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Gram-negative%20and%20gram-positive%20bacterial%20extracellular%20vesicles&amp;journal=Semin%20Cell%20Dev.%20Biol.&amp;volume=40&amp;pages=97-104&amp;publication_year=2015&amp;author=Kim%2CJH&amp;author=Lee%2CJ&amp;author=Park%2CJ&amp;author=Gho%2CYS\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR24\">Dean, S. N., Leary, D. H., Sullivan, C. J., Oh, E. &amp; Walper, S. A. Isolation and characterization of Lactobacillus-derived membrane vesicles. Sci. Rep. 9, 877 (2019).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 24\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Isolation%20and%20characterization%20of%20Lactobacillus-derived%20membrane%20vesicles&amp;journal=Sci.%20Rep.&amp;volume=9&amp;publication_year=2019&amp;author=Dean%2CSN&amp;author=Leary%2CDH&amp;author=Sullivan%2CCJ&amp;author=Oh%2CE&amp;author=Walper%2CSA\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR25\">Tong, L. et al. Milk-derived extracellular vesicles protect intestinal barrier integrity in the gut-liver axis. Sci. Adv. 9, eade5041 (2023).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 25\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Milk-derived%20extracellular%20vesicles%20protect%20intestinal%20barrier%20integrity%20in%20the%20gut-liver%20axis&amp;journal=Sci.%20Adv.&amp;volume=9&amp;publication_year=2023&amp;author=Tong%2CL\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR26\">Reif, S. et al. Cow and human milk-derived exosomes ameliorate colitis in DSS murine model. Nutrients 12, 2589 (2020).<\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR27\">Jing, R. et al. Milk-derived extracellular vesicles functionalized with anti-tumour necrosis factor-alpha nanobody and anti-microbial peptide alleviate ulcerative colitis in mice. J. Extracell. Vesicles 13, e12462 (2024).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 27\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Milk-derived%20extracellular%20vesicles%20functionalized%20with%20anti-tumour%20necrosis%20factor-alpha%20nanobody%20and%20anti-microbial%20peptide%20alleviate%20ulcerative%20colitis%20in%20mice&amp;journal=J.%20Extracell.%20Vesicles&amp;volume=13&amp;publication_year=2024&amp;author=Jing%2CR\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR28\">Sun, T. et al. Comprehensive analysis of dysregulated circular RNAs and construction of a ceRNA network involved in the pathology of Alzheimer\u2019s disease in a 5 x FAD mouse model. Front Aging Neurosci. 14, 1020699 (2022).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 28\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Comprehensive%20analysis%20of%20dysregulated%20circular%20RNAs%20and%20construction%20of%20a%20ceRNA%20network%20involved%20in%20the%20pathology%20of%20Alzheimer%E2%80%99s%20disease%20in%20a%205%20x%20FAD%20mouse%20model&amp;journal=Front%20Aging%20Neurosci.&amp;volume=14&amp;publication_year=2022&amp;author=Sun%2CT\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR29\">Ma X. et al. Akkermansia muciniphila identified as key strain to alleviate gut barrier injury through Wnt signaling pathway. Elife 12, RP92906 (2025).<\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR30\">Wade, H. et al. Akkermansia muciniphila and its membrane protein ameliorates intestinal inflammatory stress and promotes epithelial wound healing via CREBH and miR-143\/145. J. Biomed. Sci. 30, 38 (2023).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 30\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Akkermansia%20muciniphila%20and%20its%20membrane%20protein%20ameliorates%20intestinal%20inflammatory%20stress%20and%20promotes%20epithelial%20wound%20healing%20via%20CREBH%20and%20miR-143%2F145&amp;journal=J.%20Biomed.%20Sci.&amp;volume=30&amp;publication_year=2023&amp;author=Wade%2CH\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR31\">Song, S. et al. Clostridium butyricum and its metabolites regulate macrophage polarization through miR-146a to antagonize gouty arthritis. J. Adv. Res. S2090-1232, 00354-6 (2025).<\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR32\">Goldie, B. J. et al. Activity-associated miRNA are packaged in Map1b-enriched exosomes released from depolarized neurons. Nucleic Acids Res. 42, 9195\u20139208 (2014).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 32\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Activity-associated%20miRNA%20are%20packaged%20in%20Map1b-enriched%20exosomes%20released%20from%20depolarized%20neurons&amp;journal=Nucleic%20Acids%20Res&amp;volume=42&amp;pages=9195-9208&amp;publication_year=2014&amp;author=Goldie%2CBJ\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR33\">Ma, L. et al. Anti-inflammatory effect of clostridium butyricum-derived extracellular vesicles in ulcerative colitis: Impact on host microRNAs expressions and gut microbiome profiles. Mol. Nutr. Food Res. 67, e2200884 (2023).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 33\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Anti-inflammatory%20effect%20of%20clostridium%20butyricum-derived%20extracellular%20vesicles%20in%20ulcerative%20colitis%3A%20Impact%20on%20host%20microRNAs%20expressions%20and%20gut%20microbiome%20profiles&amp;journal=Mol.%20Nutr.%20Food%20Res.&amp;volume=67&amp;publication_year=2023&amp;author=Ma%2CL\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR34\">Westermann, S. et al. Th2-dependent STAT6-regulated genes in intestinal epithelial cells mediate larval trapping during secondary Heligmosomoides polygyrus bakeri infection. PLoS Pathog. 19, e1011296 (2023).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 34\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Th2-dependent%20STAT6-regulated%20genes%20in%20intestinal%20epithelial%20cells%20mediate%20larval%20trapping%20during%20secondary%20Heligmosomoides%20polygyrus%20bakeri%20infection&amp;journal=PLoS%20Pathog.&amp;volume=19&amp;publication_year=2023&amp;author=Westermann%2CS\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR35\">Deng, C. et al. Exosome circATP8A1 induces macrophage M2 polarization by regulating the miR-1-3p\/STAT6 axis to promote gastric cancer progression. Mol. Cancer 23, 49 (2024).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 35\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Exosome%20circATP8A1%20induces%20macrophage%20M2%20polarization%20by%20regulating%20the%20miR-1-3p%2FSTAT6%20axis%20to%20promote%20gastric%20cancer%20progression&amp;journal=Mol.%20Cancer&amp;volume=23&amp;publication_year=2024&amp;author=Deng%2CC\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR36\">Selbach, M. et al. Widespread changes in protein synthesis induced by microRNAs. Nature 455, 58\u201363 (2008).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 36\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Widespread%20changes%20in%20protein%20synthesis%20induced%20by%20microRNAs&amp;journal=Nature&amp;volume=455&amp;pages=58-63&amp;publication_year=2008&amp;author=Selbach%2CM\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR37\">Wang, L. X., Zhang, S. X., Wu, H. J., Rong, X. L. &amp; Guo, J. M2b macrophage polarization and its roles in diseases. J. Leukoc. Biol. 106, 345\u2013358 (2019).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 37\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=M2b%20macrophage%20polarization%20and%20its%20roles%20in%20diseases&amp;journal=J.%20Leukoc.%20Biol.&amp;volume=106&amp;pages=345-358&amp;publication_year=2019&amp;author=Wang%2CLX&amp;author=Zhang%2CSX&amp;author=Wu%2CHJ&amp;author=Rong%2CXL&amp;author=Guo%2CJ\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR38\">Song, M. et al. Diarrheal microbiota-derived extracellular vesicles drive intestinal homeostasis dysfunction via miR-125b\/NF-kappaB-mediated macrophage polarization. Gut Microbes 17, 2541036 (2025).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 38\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Diarrheal%20microbiota-derived%20extracellular%20vesicles%20drive%20intestinal%20homeostasis%20dysfunction%20via%20miR-125b%2FNF-kappaB-mediated%20macrophage%20polarization&amp;journal=Gut%20Microbes&amp;volume=17&amp;publication_year=2025&amp;author=Song%2CM\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR39\">Tao, S. et al. Extracellular vesicles derived from Lactobacillus johnsonii promote gut barrier homeostasis by enhancing M2 macrophage polarization. J. Adv. Res. 69, 545\u2013563 (2025).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 39\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Extracellular%20vesicles%20derived%20from%20Lactobacillus%20johnsonii%20promote%20gut%20barrier%20homeostasis%20by%20enhancing%20M2%20macrophage%20polarization&amp;journal=J.%20Adv.%20Res.&amp;volume=69&amp;pages=545-563&amp;publication_year=2025&amp;author=Tao%2CS\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR40\">Li, J. et al. Limosilactobacillus mucosae-derived extracellular vesicles modulates macrophage phenotype and orchestrates gut homeostasis in a diarrheal piglet model. NPJ Biofilms Microbiomes 9, 33 (2023).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 40\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Limosilactobacillus%20mucosae-derived%20extracellular%20vesicles%20modulates%20macrophage%20phenotype%20and%20orchestrates%20gut%20homeostasis%20in%20a%20diarrheal%20piglet%20model&amp;journal=NPJ%20Biofilms%20Microbiomes&amp;volume=9&amp;publication_year=2023&amp;author=Li%2CJ\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR41\">Tao, S. et al. Lactobacillus johnsonii-derived extracellular vesicles carrying GAPDH protect against ulcerative colitis through modulating macrophage polarization. J. Adv. Res. S2090-1232, 00444\u20138 (2025).<\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR42\">Okabe, Y. &amp; Medzhitov, R. Tissue-specific signals control reversible program of localization and functional polarization of macrophages. Cell 157, 832\u2013844 (2014).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 42\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Tissue-specific%20signals%20control%20reversible%20program%20of%20localization%20and%20functional%20polarization%20of%20macrophages&amp;journal=Cell&amp;volume=157&amp;pages=832-844&amp;publication_year=2014&amp;author=Okabe%2CY&amp;author=Medzhitov%2CR\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR43\">Honda, M., Kadohisa, M., Yoshii, D., Komohara, Y. &amp; Hibi, T. Directly recruited GATA6 + peritoneal cavity macrophages contribute to the repair of intestinal serosal injury. Nat. Commun. 12, 7294 (2021).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 43\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Directly%20recruited%20GATA6%20%2B%20peritoneal%20cavity%20macrophages%20contribute%20to%20the%20repair%20of%20intestinal%20serosal%20injury&amp;journal=Nat.%20Commun.&amp;volume=12&amp;publication_year=2021&amp;author=Honda%2CM&amp;author=Kadohisa%2CM&amp;author=Yoshii%2CD&amp;author=Komohara%2CY&amp;author=Hibi%2CT\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR44\">Wijayatunga, N. N. et al. An integrative transcriptomic approach to identify depot differences in genes and microRNAs in adipose tissues from high fat fed mice. Oncotarget 9, 9246\u20139261 (2018).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 44\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=An%20integrative%20transcriptomic%20approach%20to%20identify%20depot%20differences%20in%20genes%20and%20microRNAs%20in%20adipose%20tissues%20from%20high%20fat%20fed%20mice&amp;journal=Oncotarget&amp;volume=9&amp;pages=9246-9261&amp;publication_year=2018&amp;author=Wijayatunga%2CNN\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR45\">Xiong, L. et al. Acute exposure to high-fat diet impairs ILC3 functions and gut homeostasis. Immunity 58, 1185\u20131200 e1188 (2025).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 45\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Acute%20exposure%20to%20high-fat%20diet%20impairs%20ILC3%20functions%20and%20gut%20homeostasis&amp;journal=Immunity&amp;volume=58&amp;pages=1185-1200%20e1188&amp;publication_year=2025&amp;author=Xiong%2CL\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR46\">Chaves-Perez, A. et al. Metabolic adaptations direct cell fate during tissue regeneration. Nature 643, 468\u2013477 (2025).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 46\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Metabolic%20adaptations%20direct%20cell%20fate%20during%20tissue%20regeneration&amp;journal=Nature&amp;volume=643&amp;pages=468-477&amp;publication_year=2025&amp;author=Chaves-Perez%2CA\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR47\">Pi, Y. et al. Gut microbiota-derived ursodeoxycholic acid alleviates low birth weight-induced colonic inflammation by enhancing M2 macrophage polarization. Microbiome 11, 19 (2023).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 47\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Gut%20microbiota-derived%20ursodeoxycholic%20acid%20alleviates%20low%20birth%20weight-induced%20colonic%20inflammation%20by%20enhancing%20M2%20macrophage%20polarization&amp;journal=Microbiome&amp;volume=11&amp;publication_year=2023&amp;author=Pi%2CY\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR48\">Shen, Q. et al. Extracellular vesicle miRNAs promote the intestinal microenvironment by interacting with microbes in colitis. Gut Microbes 14, 2128604 (2022).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 48\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Extracellular%20vesicle%20miRNAs%20promote%20the%20intestinal%20microenvironment%20by%20interacting%20with%20microbes%20in%20colitis&amp;journal=Gut%20Microbes&amp;volume=14&amp;publication_year=2022&amp;author=Shen%2CQ\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR49\">Tao, S., Bai, Y., Li, T., Li, N. &amp; Wang, J. Original low birth weight deteriorates the hindgut epithelial barrier function in pigs at the growing stage. FASEB J. 33, 9897\u20139912 (2019).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 49\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Original%20low%20birth%20weight%20deteriorates%20the%20hindgut%20epithelial%20barrier%20function%20in%20pigs%20at%20the%20growing%20stage&amp;journal=FASEB%20J.&amp;volume=33&amp;pages=9897-9912&amp;publication_year=2019&amp;author=Tao%2CS&amp;author=Bai%2CY&amp;author=Li%2CT&amp;author=Li%2CN&amp;author=Wang%2CJ\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR50\">Wu, X. et al. Saccharomyces boulardii ameliorates Citrobacter rodentium-induced colitis through actions on bacterial virulence factors. Am. J. Physiol. Gastrointest. Liver Physiol. 294, G295\u2013G306 (2008).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 50\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Saccharomyces%20boulardii%20ameliorates%20Citrobacter%20rodentium-induced%20colitis%20through%20actions%20on%20bacterial%20virulence%20factors&amp;journal=Am.%20J.%20Physiol.%20Gastrointest.%20Liver%20Physiol.&amp;volume=294&amp;pages=G295-G306&amp;publication_year=2008&amp;author=Wu%2CX\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n","protected":false},"excerpt":{"rendered":"Magro, D. O., Sassaki, L. Y. &amp; Chebli, J. M. F. Interaction between diet and genetics in patients&hellip;\n","protected":false},"author":2,"featured_media":256119,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[7],"tags":[1112,7308,3181,85,10922,46,3183,18494,31369,24646,3488,141],"class_list":{"0":"post-256118","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-science","8":"tag-diseases","9":"tag-gastroenterology","10":"tag-general","11":"tag-il","12":"tag-immunology","13":"tag-israel","14":"tag-life-sciences","15":"tag-medical-microbiology","16":"tag-microbial-ecology","17":"tag-microbial-genetics-and-genomics","18":"tag-microbiology","19":"tag-science"},"_links":{"self":[{"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/posts\/256118","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/comments?post=256118"}],"version-history":[{"count":0,"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/posts\/256118\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/media\/256119"}],"wp:attachment":[{"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/media?parent=256118"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/categories?post=256118"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/tags?post=256118"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}