{"id":309876,"date":"2026-02-25T18:06:09","date_gmt":"2026-02-25T18:06:09","guid":{"rendered":"https:\/\/www.newsbeep.com\/il\/309876\/"},"modified":"2026-02-25T18:06:09","modified_gmt":"2026-02-25T18:06:09","slug":"new-study-links-gut-makeup-to-celiac-disease-development","status":"publish","type":"post","link":"https:\/\/www.newsbeep.com\/il\/309876\/","title":{"rendered":"New study links gut makeup to celiac disease development"},"content":{"rendered":"<p>Specific genetic architecture in the gut microbial ecosystem can shape microbial composition in ways that are potentially relevant to the pathogenesis of celiac disease, according to a study published this month in\u00a0Nature Genetics.<\/p>\n<p><a href=\"https:\/\/www.medcentral.com\/gastroenterology\/new-study-links-gut-makeup-to-celiac-disease-pathogenesis\" target=\"_blank\" style=\"letter-spacing: 0.3px;\" rel=\"nofollow noopener\">As MedCentral recently reported<\/a>, although the community of micro-organisms in the gastrointestinal (GI) tract, also known as the gut microbiota, is associated with many diseases \u2014 and research suggests that genetic predisposition may play a role \u2014 no specific microbial species has been consistently shown to drive the progression of celiac disease, a GI condition characterized by the loss of gluten tolerance.\u00a0<\/p>\n<p>\u201cOverall, the HUNT study is very fascinating, bringing to light the delicate interplay of genetic predisposition and the microbiome,\u201d\u00a0<a href=\"https:\/\/med.uc.edu\/landing-pages\/profile\/index\/pubs\/kaisss\" style=\"letter-spacing: 0.3px;\" rel=\"nofollow noopener\" target=\"_blank\">Susan S. Kais, MD<\/a>, a gastroenterologist and assistant professor of clinical medicine at the University of Cincinnati College of Medicine, told MedCentral. \u201cTo date, our understanding has been that celiac disease is due to gluten intolerance driven by a person\u2019s genetic predisposition and not much has been discussed about the role of microbiomes and the development of celiac disease. Now we know that if the diagnosis is questionable despite testing and duodenal biopsies \u2014 the gold standard of diagnosis \u2014 then we can order HLA-DQ2 and HLA-DQ8 genotyping to confirm the diagnosis.\u201d Kais was not involved in the study.<\/p>\n<p>Kais told MedCentral the HUNT study raises a valid hypothesis about this genetic-microbiome interplay, but there is no exact mechanism for it to date.<\/p>\n<p>\u201cA dysregulated microbiome may disrupt the balance of immune responses, leading to an inappropriate reaction to gluten in genetically predisposed individuals. The presence of beneficial bacteria, such as\u00a0Agathobacter, may support immune balance, whereas their reduced microbial diversity may increase susceptibility to celiac disease,\u201d she explained. \u201cThis remains a hypothesis too early to be implemented clinically, and more studies are needed.\u201d<\/p>\n<p>Kais, a faculty member in the Division of Gastroenterology and Hepatology in the Department of Internal Medicine, emphasized the HUNT study findings encourage clinicians to look beyond current understanding of how genetics and microbiomes affect celiac disease, adding that physicians should consider screening individuals with specific genetic markers and assessing their gut microbiota composition to support early detection and risk stratification for celiac disease.<\/p>\n<p>\u201cFor those at risk of the disease, preventive strategies may include modulating the gut microbiota through a high-fiber diet and recommending personalized microbiome therapies, such as probiotics or prebiotics, to enhance protective\u00a0Agathobacter sp.\u00a0activity,\u201d she concluded.<\/p>\n<p><a href=\"https:\/\/www.medcentral.com\/gastroenterology\/new-study-links-gut-makeup-to-celiac-disease-pathogenesis\" target=\"_blank\" rel=\"nofollow noopener\">Read the full MedCentral article.<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"Specific genetic architecture in the gut microbial ecosystem can shape microbial composition in ways that are potentially relevant&hellip;\n","protected":false},"author":2,"featured_media":309877,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[10],"tags":[56354,56352,28162,163,85,1389,3861,46,43,1360],"class_list":{"0":"post-309876","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-health","8":"tag-academic-health-center","9":"tag-college-of-medicine","10":"tag-faculty-staff","11":"tag-health","12":"tag-il","13":"tag-in-the-news","14":"tag-internal-medicine","15":"tag-israel","16":"tag-news","17":"tag-research"},"_links":{"self":[{"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/posts\/309876","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/comments?post=309876"}],"version-history":[{"count":0,"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/posts\/309876\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/media\/309877"}],"wp:attachment":[{"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/media?parent=309876"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/categories?post=309876"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/tags?post=309876"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}