{"id":351396,"date":"2026-03-21T22:06:32","date_gmt":"2026-03-21T22:06:32","guid":{"rendered":"https:\/\/www.newsbeep.com\/il\/351396\/"},"modified":"2026-03-21T22:06:32","modified_gmt":"2026-03-21T22:06:32","slug":"gut-microbiota-disruption-identified-in-fpies-children","status":"publish","type":"post","link":"https:\/\/www.newsbeep.com\/il\/351396\/","title":{"rendered":"Gut Microbiota Disruption Identified in FPIES Children"},"content":{"rendered":"<p>CHANGES in\u00a0<a href=\"https:\/\/www.emjreviews.com\/general-healthcare\/news\/gut-microbiota-linked-to-childhood-asthma-risk-in-new-genetic-study\/\" rel=\"nofollow noopener\" target=\"_blank\">gut microbiota<\/a>\u00a0were\u00a0observed\u00a0at diagnosis in children with food protein-induced enterocolitis syndrome (FPIES), highlighting a potential microbial role in early disease development.\u00a0<\/p>\n<p>FPIES is a non-IgE-mediated food allergy that primarily affects infants and young children, often presenting with delayed gastrointestinal symptoms such as vomiting and diarrhoea. While its exact cause\u00a0remains\u00a0unclear, growing evidence has suggested that early-life gut microbiota may influence immune development and disease onset.\u00a0<\/p>\n<p>Gut Microbiota Differences at\u00a0FPIES\u00a0Diagnosis\u00a0<\/p>\n<p>In this study, researchers analysed faecal samples from 56 children at the time of FPIES diagnosis and compared them with 43 age-matched healthy controls. Participants were stratified into three age groups, ranging from young infants to children approaching 1 year of age. Gut microbiota composition was assessed using 16S rRNA gene sequencing.\u00a0<\/p>\n<p>Age\u00a0emerged\u00a0as the strongest determinant of gut microbiota composition, reflecting normal microbial development in early life. However, FPIES status was the second most significant factor, with clear differences\u00a0identified\u00a0between affected children and controls (p&lt;0.01).\u00a0<\/p>\n<p>Notably, children with FPIES showed reduced abundance of\u00a0Bifidobacterium, a genus widely considered beneficial for gut and immune health. In contrast, increased levels of\u00a0Bacteroides,\u00a0Haemophilus, and\u00a0Veillonella\u00a0were\u00a0observed. Shifts in major bacterial phyla, including\u00a0Bacteroidota, Proteobacteria,\u00a0Actinobacteriota, and\u00a0Verrucomicrobiota, contributed to these differences.\u00a0<\/p>\n<p>Importantly, reduced levels of\u00a0Verrucomicrobiota\u00a0were linked to specific food triggers associated with FPIES, suggesting that microbial composition may interact with dietary factors in shaping disease expression.\u00a0<\/p>\n<p>Implications for Early-Life Immune Development\u00a0<\/p>\n<p>These findings support the concept of gut microbial dysbiosis in FPIES, characterised by a loss of symbiotic bacteria and expansion of potentially pro-inflammatory taxa. Given the critical role of early microbiota in immune system maturation, such imbalances may contribute to abnormal immune responses to dietary proteins.\u00a0<\/p>\n<p>However, the cross-sectional design\u00a0of the study\u00a0limited causal interpretation. It\u00a0remains\u00a0unclear whether microbial changes drive disease onset or arise\u00a0as a consequence of\u00a0altered diet or inflammation. Additionally, microbiota composition is highly dynamic in infancy, which may influence variability in the findings.\u00a0<\/p>\n<p>Despite these limitations, the study\u00a0provides\u00a0important insight into the microbial landscape at the point of FPIES diagnosis. Future longitudinal studies are needed to\u00a0determine\u00a0whether early microbiota-targeted interventions, such as probiotics or dietary modulation, could reduce disease risk or severity.\u00a0<\/p>\n<p>Reference\u00a0<\/p>\n<p>Winberg A et al. Loss of symbiotic gut bacteria in children at diagnosis of food protein induced enterocolitis syndrome. J Allergy Clin Immunol. 2026; DOI:10.1016\/j.jaci.2026.02.043.\u00a0<\/p>\n<p>Featured image:\u00a0zilvergolf\u00a0on Adobe Stock\u00a0<\/p>\n","protected":false},"excerpt":{"rendered":"CHANGES in\u00a0gut microbiota\u00a0were\u00a0observed\u00a0at diagnosis in children with food protein-induced enterocolitis syndrome (FPIES), highlighting a potential microbial role in&hellip;\n","protected":false},"author":2,"featured_media":351397,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[10],"tags":[163,85,46],"class_list":{"0":"post-351396","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-health","8":"tag-health","9":"tag-il","10":"tag-israel"},"_links":{"self":[{"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/posts\/351396","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/comments?post=351396"}],"version-history":[{"count":0,"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/posts\/351396\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/media\/351397"}],"wp:attachment":[{"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/media?parent=351396"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/categories?post=351396"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/tags?post=351396"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}