{"id":373286,"date":"2026-04-03T17:13:10","date_gmt":"2026-04-03T17:13:10","guid":{"rendered":"https:\/\/www.newsbeep.com\/il\/373286\/"},"modified":"2026-04-03T17:13:10","modified_gmt":"2026-04-03T17:13:10","slug":"study-shows-peritoneal-mesothelioma-microenvironment-creates-poor-immunotherapy-response","status":"publish","type":"post","link":"https:\/\/www.newsbeep.com\/il\/373286\/","title":{"rendered":"Study Shows Peritoneal Mesothelioma Microenvironment Creates Poor Immunotherapy Response"},"content":{"rendered":"

Australian researchers have discovered that peritoneal mesothelioma develops in an immune-suppressive tumor microenvironment that makes it resistant to checkpoint immunotherapy<\/a>. These findings explain the significant difference between pleural mesothelioma and peritoneal mesothelioma patients observed in clinical trials. \u00a0<\/p>\n

\"immunotherapy\"\/<\/p>\n

Mesothelioma Location Influences Immune Response and Treatment Effectiveness<\/p>\n

The study, published in Scientific Reports, compared identical mesothelioma cells implanted in three different anatomical locations in mice: the pleural cavity, the abdominal cavity, and under the skin. The research showed that the peritoneal location actually created a tumor<\/a> microenvironment and a gene signature typical of limited response to immune checkpoint therapy.<\/p>\n

While the immune checkpoint therapy was effective in the mesothelioma cells implanted subcutaneously, the same cell line-derived tumors were unresponsive when implanted intraperitoneally. This demonstrates that anatomical location fundamentally alters treatment outcomes. While pleural and peritoneal mesothelioma tumors grew to similar sizes, subcutaneous tumors were significantly smaller when harvested at the same time point.<\/p>\n

Both the peritoneal and pleural mesothelioma tumors invaded nearby organs early, with peritoneal tumors spreading to the pancreas and liver, and pleural tumors invading the heart and diaphragm, but the pleural tumors showed more immune cells clustering around them compared to the peritoneal tumors, meaning that the immune system responded more actively to mesothelioma in the chest than in the abdomen.<\/p>\n

Mesothelioma Immune Microenvironment Differences Suggest Combination Therapy Strategies<\/p>\n

The research suggests that future mesothelioma treatments may need to combine immunotherapy with other drugs that \u201cwake up\u201d or reprogram inactive immune cells in the abdomen. Recent studies have shown that drugs can shift the immune system from tumor-supporting to tumor-fighting, which suggests that this type of combination strategy may be able to overcome the immunotherapy resistance seen in peritoneal mesothelioma patients.<\/p>\n

The study\u2019s results show that where mesothelioma tumors grow\u2014the chest versus the abdomen\u2014has a significant influence on how the immune system responds and whether immunotherapy will work. This explains both why peritoneal mesothelioma patients need different treatment approaches than those with pleural tumors, and suggests potential approaches to offset this difference. \u00a0<\/p>\n

If you or someone you love has been diagnosed with mesothelioma, this type of research helps provide better outcomes. If you need more information or access to helpful resources, contact the Patient Advocates at Mesothelioma.net today at 1-800-692-8608.<\/p>\n

\"Terri<\/p>\n

\n Terri Oppenheimer
\n Writer\n <\/p>\n

\t\tTerri Heimann Oppenheimer is the head writer of our Mesothelioma.net news blog. She graduated from the College of William and Mary with a degree in English. Terri believes that knowledge is power and she is committed to sharing news about the impact of mesothelioma, the latest research and medical breakthroughs, and victims\u2019 stories.<\/p>\n

Learn More About And Contact Terri<\/a> <\/p>\n","protected":false},"excerpt":{"rendered":"Australian researchers have discovered that peritoneal mesothelioma develops in an immune-suppressive tumor microenvironment that makes it resistant to…\n","protected":false},"author":2,"featured_media":373287,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[10],"tags":[163,85,46],"class_list":{"0":"post-373286","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-health","8":"tag-health","9":"tag-il","10":"tag-israel"},"_links":{"self":[{"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/posts\/373286","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/comments?post=373286"}],"version-history":[{"count":0,"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/posts\/373286\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/media\/373287"}],"wp:attachment":[{"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/media?parent=373286"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/categories?post=373286"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/tags?post=373286"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}