Virus with links to yellow fever discovered in Scotland for first time<\/a>\n<\/p>\n\n Researchers next analysed fresh intestinal tissue samples using a cutting-edge technique to study gene activity in individual cells, known as single-cell RNA sequencing.\n<\/p>\n
\n They identified a link between clusters of immune cells, known as Crohn\u2019s lymphoid aggregates, and groups of endothelial cells, which normally line blood vessels.\n<\/p>\n
\n Scientists found that the endothelial cells appeared to form distinctive structures surrounding the Crohn\u2019s lymphoid aggregates.\n<\/p>\n
\n Further analysis revealed signalling interactions between these clusters and nearby cells responsible for producing collagen, suggesting they may actively promote fibrosis.\n<\/p>\n
\n Dr Michael Glinka, research fellow at the University of Edinburgh, said: \u201cOur findings highlight previously unrecognised interactions between immune cells, endothelial cells and collagen-producing cells in Crohn\u2019s disease.\n<\/p>\n
\n \u201cBy combining traditional pathology with single-cell transcriptomics, we were able to confirm these changes using two independent approaches and uncover biological signalling pathways that may provide new therapeutic targets.\u201d\n<\/p>\n
\n The research is published in The Journal of Pathology.\n<\/p>\n
\n It was conducted by a UK-wide collaboration of researchers and clinicians and was supported by funding from the Leona M and Harry B Helmsley Charitable Trust.\n<\/p>\n
\n Catherine Winsor, director of service, research and evidence at the charity Crohn\u2019s & Colitis UK, said: \u201cPeople who live with Crohn\u2019s often tell us how much fibrosis and scarring can affect their lives, yet it\u2019s something current treatments don\u2019t address.\n<\/p>\n
\n \u201cThis early research is really exciting because it helps us to understand what drives that scarring and where new treatments could make a difference.\n<\/p>\n
\n \u201cIt brings real hope that, in the future, we might be able to treat not just inflammation, but the lasting damage Crohn\u2019s can cause.\u201d<\/p>\n","protected":false},"excerpt":{"rendered":"It is hoped the discovery, detailed in a new study, could help develop treatments to prevent or slow…\n","protected":false},"author":2,"featured_media":377515,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[10],"tags":[163,85,46],"class_list":{"0":"post-377514","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-health","8":"tag-health","9":"tag-il","10":"tag-israel"},"_links":{"self":[{"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/posts\/377514","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/comments?post=377514"}],"version-history":[{"count":0,"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/posts\/377514\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/media\/377515"}],"wp:attachment":[{"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/media?parent=377514"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/categories?post=377514"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/tags?post=377514"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}