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<\/a><\/p>\n\u201cOur findings highlight a potentially concerning role for NAD+-boosting supplements in the context of an active cancer, especially when used in conjunction with chemotherapy,\u201d says study lead author Jordan Winter, a professor at Case Western Reserve School of Medicine.<\/p>\n
\u201cOur discovery is a call to action for the medical community.\u201d<\/p>\n
Fuel for cancer cells<\/p>\n
NAD+ precursor supplements include nicotinamide mononucleotide (NMN), nicotinamide riboside (NR), and nicotinamide (NAM). These are often marketed to boost energy, slow aging, and protect the heart and brain.<\/p>\n
Published in Cancer Letters<\/a>, the study investigates how NAD+ precursor supplements affect pancreatic cancer, which is one of the deadliest cancers. The American Cancer Society reports it has a five-year survival rate of just 13%.<\/p>\n The authors explain that cancer cells hijack the same NAD+ \u201cfuel\u201d that healthy cells use to \u201cpower up\u201d energy systems, repair DNA damage from chemotherapy, and avoid the cell death that chemotherapy triggers.<\/p>\n In both laboratory cell culture experiments and mouse models, the supplements \u2014 particularly NMN \u2014 shielded pancreatic cancer cells from three standard chemotherapy drugs: oxaliplatin, 5-fluororouracil, and gemcitabine.<\/p>\n \u201cThis research is a critical reminder that \u2018natural\u2019 doesn\u2019t always mean safe, especially in the complex biology of cancer treatment,\u201d Winter cautions. For now, he advises cancer patients to discuss the potential risks with their oncologist and medical team immediately.<\/p>\n The researchers call for routine screening of supplement use in all cancer patients and further clinical research about the interaction between NAD+ supplements and cancer therapies.<\/p>\n Genuine benefits for healthy individuals<\/p>\n In healthy people, the study authors note NAD+ supplements may offer genuine benefits across broad areas. This has been backed by recent Nestl\u00e9-led clinical research<\/a> demonstrating that NAD+ booster supplements promote health in \u201cunexpected\u201d areas of gut health by enhancing beneficial bacteria in the digestive system.<\/p>\n Access to these supplements is also widening. Earlier this year, Niagen Bioscience\u2019s direct-to-consumer website partnered with payment platform Truemed to offer eligible US-based customers the option to purchase its NAD+ booster, Tru Niagen<\/a>, for a lower cost using pre-tax health care dollars.<\/p>\nNAD+ precursor supplements are often marketed to boost energy, slow aging, and protect the heart and brain.They learned that a combination of these factors allows tumors to survive doses of medicine that should be lethal. The supplements were found to reduce oxidative stress in tumors, neutralizing one of chemotherapy\u2019s key mechanisms for destroying cancer cells.<\/p>\n