{"id":406797,"date":"2026-04-23T12:50:08","date_gmt":"2026-04-23T12:50:08","guid":{"rendered":"https:\/\/www.newsbeep.com\/il\/406797\/"},"modified":"2026-04-23T12:50:08","modified_gmt":"2026-04-23T12:50:08","slug":"liquid-biopsy-genomic-profiling-in-prostate-cancer","status":"publish","type":"post","link":"https:\/\/www.newsbeep.com\/il\/406797\/","title":{"rendered":"Liquid Biopsy Genomic Profiling in Prostate Cancer"},"content":{"rendered":"<p>LIQUID BIOPSY-BASED\u00a0genomic profiling could offer a reliable and less invasive alternative to tissue sampling in patients with high-risk localised\u00a0<a href=\"https:\/\/www.emjreviews.com\/urology\/news\/erection-pills-under-prescribed-in-patients-with-prostate-cancer\/\" rel=\"nofollow noopener\" target=\"_blank\">prostate cancer<\/a>, particularly where tumour tissue is limited or of\u00a0poor quality, according to a new study.\u00a0<\/p>\n<p>Genomic profiling is increasingly used to guide treatment decisions by\u00a0identifying\u00a0tumour-specific mutations. While liquid biopsies,\u00a0tests that analyse circulating tumour DNA (ctDNA) in blood,\u00a0are already\u00a0established\u00a0in metastatic prostate cancer, their role in localised disease has\u00a0remained\u00a0uncertain due to typically low levels of ctDNA.\u00a0<\/p>\n<p>In this phase 2 neoadjuvant study, researchers evaluated both tissue- and plasma-based genomic profiling in patients with high-risk localised disease. The team analysed DNA extracted from formalin-fixed paraffin-embedded (FFPE) tumour samples alongside cell-free DNA from plasma, using the Illumina\u00a0TruSight\u00a0Oncology 500 platform and advanced bioinformatics pipelines.\u00a0<\/p>\n<p>Higher Success Rates with\u00a0Liquid Biopsy\u00a0<\/p>\n<p>The findings revealed a marked difference in sequencing success rates between the two approaches. Of 22 tissue biopsy samples, only 54.5% yielded usable genomic data, with failures\u00a0largely attributed\u00a0to insufficient DNA quality or quantity. In contrast, all 27 plasma samples were successfully sequenced, despite the\u00a0anticipated\u00a0challenge of low ctDNA levels in localised disease.\u00a0<\/p>\n<p>Both tissue and liquid biopsy approaches\u00a0identified\u00a0a similar average of 3.5 genomic alterations per sample. Detected mutations included clinically relevant genes such as SPOP, ATRX, ATM, and ARID1B, which are known to play roles in prostate cancer biology. Notably, liquid-based profiling\u00a0demonstrated\u00a0superior sequencing depth and coverage, enabling the detection of low-frequency mutations that may be missed with tissue analysis.\u00a0<\/p>\n<p>Direct comparison between matched tissue and plasma samples was limited, as only four patients had paired data available for concordance analysis. As a result, the degree of agreement between the two methods could not be robustly\u00a0established.\u00a0<\/p>\n<p>Need for Larger Studies to Confirm Clinical Utility\u00a0<\/p>\n<p>Despite this limitation, the study provides encouraging evidence that liquid biopsy is both\u00a0feasible\u00a0and technically robust in high-risk localised prostate cancer. The authors suggest that plasma-based genomic profiling could serve as a valuable complementary tool, particularly in cases where tissue biopsies are inadequate or impractical.\u00a0<\/p>\n<p>Further large-scale studies are needed to confirm concordance between methods and to\u00a0determine\u00a0how liquid biopsy findings can be integrated into clinical decision-making for patients with localised disease.\u00a0<\/p>\n<p>Reference\u00a0<\/p>\n<p>Bettoni F et al.\u00a0Liquid-based genomic profiling in high-risk localized prostate cancer. Front Urol. 2026;\u00a06:1789586.\u00a0\u00a0<\/p>\n<p>Featured image:\u00a0\u202ftilialucida\u00a0on Adobe Stock<\/p>\n","protected":false},"excerpt":{"rendered":"LIQUID BIOPSY-BASED\u00a0genomic profiling could offer a reliable and less invasive alternative to tissue sampling in patients with high-risk&hellip;\n","protected":false},"author":2,"featured_media":406798,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[10],"tags":[163,85,46],"class_list":{"0":"post-406797","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-health","8":"tag-health","9":"tag-il","10":"tag-israel"},"_links":{"self":[{"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/posts\/406797","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/comments?post=406797"}],"version-history":[{"count":0,"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/posts\/406797\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/media\/406798"}],"wp:attachment":[{"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/media?parent=406797"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/categories?post=406797"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/tags?post=406797"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}