{"id":43025,"date":"2025-09-28T13:40:08","date_gmt":"2025-09-28T13:40:08","guid":{"rendered":"https:\/\/www.newsbeep.com\/il\/43025\/"},"modified":"2025-09-28T13:40:08","modified_gmt":"2025-09-28T13:40:08","slug":"largest-study-of-its-kind-reveals-the-genes-behind-dyslexia","status":"publish","type":"post","link":"https:\/\/www.newsbeep.com\/il\/43025\/","title":{"rendered":"Largest Study of Its Kind Reveals The Genes Behind Dyslexia"},"content":{"rendered":"<p class=\"mb-4 text-lg md:leading-8 break-words\">A massive study involving genetic data from over 1.2 million people has identified over a dozen new gene regions associated with dyslexia.<\/p>\n<p class=\"mb-4 text-lg md:leading-8 break-words\">&#8220;We have produced the largest genetic study of dyslexia to date,&#8221; <a href=\"https:\/\/doi.org\/10.1038\/s41398-025-03514-0\" rel=\"nofollow noopener\" target=\"_blank\" data-ylk=\"slk:write;elm:context_link;itc:0;sec:content-canvas\" class=\"link \">write<\/a> the study authors, led by University of Edinburgh molecular geneticist Hayley Mountford.<\/p>\n<p class=\"mb-4 text-lg md:leading-8 break-words\">Dyslexia is a neurodevelopmental brain difference that can make certain aspects of modern life challenging. In the current study, participants had challenges reading and\/or writing, although that is not the case in all people with dyslexia; some find other aspects of verbal processing more challenging than their peers, such as spelling and grammar, or following verbal instructions.<\/p>\n<p class=\"mb-4 text-lg md:leading-8 break-words\">Related: <a href=\"https:\/\/www.yahoo.com\/news\/several-psychiatric-disorders-share-same-113113119.html\" data-ylk=\"slk:Several Psychiatric Disorders Share The Same Root Cause, Study Reveals;elm:context_link;itc:0;sec:content-canvas;outcm:mb_qualified_link;_E:mb_qualified_link;ct:story;\" class=\"link  yahoo-link\" rel=\"nofollow noopener\" target=\"_blank\">Several Psychiatric Disorders Share The Same Root Cause, Study Reveals<\/a><\/p>\n<p><img alt=\"child holding book open\" loading=\"lazy\" width=\"642\" height=\"427\" decoding=\"async\" data-nimg=\"1\" class=\"rounded-lg\" style=\"color:transparent\" src=\"https:\/\/www.newsbeep.com\/il\/wp-content\/uploads\/2025\/09\/b0520066d5396a3e4d9b93bfa0e386ce.jpeg\"\/><\/p>\n<p class=\"mb-4 text-lg md:leading-8 break-words\">As with the other neurodivergences, like <a class=\"link \" href=\"https:\/\/www.sciencealert.com\/autism-spectrum-disorder\" rel=\"nofollow noopener\" target=\"_blank\" data-ylk=\"slk:autism;elm:context_link;itc:0;sec:content-canvas\">autism<\/a> or <a class=\"link \" href=\"https:\/\/www.sciencealert.com\/what-is-adhd\" rel=\"nofollow noopener\" target=\"_blank\" data-ylk=\"slk:ADHD;elm:context_link;itc:0;sec:content-canvas\">ADHD<\/a>, dyslexia comes with <a href=\"https:\/\/www.sciencealert.com\/having-dyslexia-could-mean-your-brain-is-wired-to-make-better-decisions\" rel=\"nofollow noopener\" target=\"_blank\" data-ylk=\"slk:advantages as well;elm:context_link;itc:0;sec:content-canvas\" class=\"link \">advantages as well<\/a>, such as <a href=\"https:\/\/doi.org\/10.1016\/j.ridd.2021.104036\" rel=\"nofollow noopener\" target=\"_blank\" data-ylk=\"slk:higher non-verbal creativity;elm:context_link;itc:0;sec:content-canvas\" class=\"link \">higher non-verbal creativity<\/a>.<\/p>\n<p class=\"mb-4 text-lg md:leading-8 break-words\"><a href=\"https:\/\/doi.org\/10.3390\/brainsci12010027\" rel=\"nofollow noopener\" target=\"_blank\" data-ylk=\"slk:Past twin studies;elm:context_link;itc:0;sec:content-canvas\" class=\"link \">Past twin studies<\/a> have suggested that genes strongly determine dyslexia, so Mountford and colleagues took up the challenge of pinpointing what those genetic associations are.<\/p>\n<p class=\"mb-4 text-lg md:leading-8 break-words\">Their genome-wide study identified 80 regions associated with dyslexia, including 36 regions not previously reported as significant. Thirteen of these regions were novel to science, with no prior link to dyslexia.<\/p>\n<p class=\"mb-4 text-lg md:leading-8 break-words\">Many of the newly associated genes are involved in early brain development. And, as expected, some of them are <a href=\"https:\/\/doi.org\/10.1177\/09567976241293999\" rel=\"nofollow noopener\" target=\"_blank\" data-ylk=\"slk:shared with ADHD;elm:context_link;itc:0;sec:content-canvas\" class=\"link \">shared with ADHD<\/a>, which can often occur alongside dyslexia.<\/p>\n<p class=\"mb-4 text-lg md:leading-8 break-words\">In the vast datasets, the researchers also found correlations between dyslexia and measures of <a href=\"https:\/\/www.sciencealert.com\/large-body-map-study-suggests-chronic-pain-comes-in-9-distinct-types\" rel=\"nofollow noopener\" target=\"_blank\" data-ylk=\"slk:chronic pain;elm:context_link;itc:0;sec:content-canvas\" class=\"link \">chronic pain<\/a>.<\/p>\n<p class=\"mb-4 text-lg md:leading-8 break-words\">&#8220;The underlying mechanism remains unelucidated, however, the genetic overlap between pain-related phenotypes and neurodevelopmental traits may hint at a shared biological basis,&#8221; Mountford and team <a href=\"https:\/\/doi.org\/10.1038\/s41398-025-03514-0\" rel=\"nofollow noopener\" target=\"_blank\" data-ylk=\"slk:write;elm:context_link;itc:0;sec:content-canvas\" class=\"link \">write<\/a> in their paper.<\/p>\n<p class=\"mb-4 text-lg md:leading-8 break-words\">With these newly identified gene associations, researchers might finally start unraveling these connections.<\/p>\n<p class=\"mb-4 text-lg md:leading-8 break-words\">This research was published in <a href=\"https:\/\/doi.org\/10.1038\/s41398-025-03514-0\" rel=\"nofollow noopener\" target=\"_blank\" data-ylk=\"slk:Translational Psychiatry;elm:context_link;itc:0;sec:content-canvas\" class=\"link \">Translational Psychiatry<\/a>.<\/p>\n<p>Related News<\/p>\n","protected":false},"excerpt":{"rendered":"A massive study involving genetic data from over 1.2 million people has identified over a dozen new gene&hellip;\n","protected":false},"author":2,"featured_media":43026,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[25],"tags":[34229,377,85,46,141],"class_list":["post-43025","post","type-post","status-publish","format-standard","has-post-thumbnail","category-genetics","tag-genetic-associations","tag-genetics","tag-il","tag-israel","tag-science"],"_links":{"self":[{"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/posts\/43025","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/comments?post=43025"}],"version-history":[{"count":0,"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/posts\/43025\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/media\/43026"}],"wp:attachment":[{"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/media?parent=43025"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/categories?post=43025"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/tags?post=43025"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}