{"id":532149,"date":"2026-07-09T00:59:19","date_gmt":"2026-07-09T00:59:19","guid":{"rendered":"https:\/\/www.newsbeep.com\/il\/532149\/"},"modified":"2026-07-09T00:59:19","modified_gmt":"2026-07-09T00:59:19","slug":"what-you-need-to-know-about-attr-cm-and-vitamin-a-supplementation","status":"publish","type":"post","link":"https:\/\/www.newsbeep.com\/il\/532149\/","title":{"rendered":"What You Need to Know About ATTR-CM and Vitamin A Supplementation"},"content":{"rendered":"

In ATTR-CM, transthyretin proteins become unstable and fold the wrong way.<\/p>\n

[1]<\/p>\n

\u00a0You can picture TTR protein folding like making a paper airplane. If you fold one wing in the opposite direction, your airplane won\u2019t fly.When TTR proteins don\u2019t fold right, they can\u2019t move like they should. Then, they build up in your organs, including your heart, says Tadeo Diaz Balderrama, MD<\/a>, a cardiologist for SSM Health in Fond du Lac, Wisconsin.<\/p>\n

[1]<\/p>\n

This can lead to symptoms of heart failure, like shortness of breath and swelling in your legs.<\/p>\n

[2]<\/p>\n

Vitamin A fits into this equation when you treat ATTR-CM with medications that decrease the amount of the TTR proteins that transport it.<\/p>\n

\u201cVitamin A (retinol) does not circulate freely in the blood,\u201d says Julia Zumpano, RD<\/a>, who specializes in metabolic nutrition and clinical nutrition at Cleveland Clinic in Ohio. \u201cInstead, retinol binds to a carrier protein called retinol-binding protein (RBP).\u201d<\/p>\n

[5]<\/p>\n

\u00a0Then, this combination connects to TTR, which helps your body use vitamin A, says Zumpano.<\/p>\n

[1]<\/p>\n

ATTR-CM treatments work in two ways:<\/p>\n

[6]<\/p>\n

Stabilizers hold TTR proteins in place so they can\u2019t fold incorrectly.Silencers lower the amount of TTR proteins made by your liver.<\/p>\n

\u201cSilencers can cause a functional vitamin A deficiency since they reduce the overall production of TTR, the primary vitamin A protein transporter,\u201d says Dr. Hicks.<\/p>\n

ATTR-CM silencers include:<\/p>\n

[4]<\/p>\n

patisiran (Onpattro)inotersen (Tegsedi)vutrisiran (Amvuttra)<\/p>\n

[7]<\/p>\n","protected":false},"excerpt":{"rendered":"In ATTR-CM, transthyretin proteins become unstable and fold the wrong way. [1] \u00a0You can picture TTR protein folding…\n","protected":false},"author":2,"featured_media":532150,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[36],"tags":[163,85,46,543],"class_list":["post-532149","post","type-post","status-publish","format-standard","has-post-thumbnail","category-nutrition","tag-health","tag-il","tag-israel","tag-nutrition"],"_links":{"self":[{"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/posts\/532149","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/comments?post=532149"}],"version-history":[{"count":0,"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/posts\/532149\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/media\/532150"}],"wp:attachment":[{"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/media?parent=532149"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/categories?post=532149"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/tags?post=532149"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}