{"id":547146,"date":"2026-07-18T05:00:14","date_gmt":"2026-07-18T05:00:14","guid":{"rendered":"https:\/\/www.newsbeep.com\/il\/547146\/"},"modified":"2026-07-18T05:00:14","modified_gmt":"2026-07-18T05:00:14","slug":"regulatory-and-metabolic-control-of-microbial-biosynthetic-gene-clusters","status":"publish","type":"post","link":"https:\/\/www.newsbeep.com\/il\/547146\/","title":{"rendered":"Regulatory and metabolic control of microbial biosynthetic gene clusters"},"content":{"rendered":"<p class=\"c-article-references__text\" id=\"ref-CR1\">Schmidt, B. et al. A natural history of botanical therapeutics. Metabolism 57, S3\u2013S9 (2008).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1016\/j.metabol.2008.03.001\" data-track-item_id=\"10.1016\/j.metabol.2008.03.001\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1016%2Fj.metabol.2008.03.001\" aria-label=\"Article reference 1\" data-doi=\"10.1016\/j.metabol.2008.03.001\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DC%2BD1cXnt1emtLc%3D\" aria-label=\"CAS reference 1\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=18555851\" aria-label=\"PubMed reference 1\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2981029\" aria-label=\"PubMed Central reference 1\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 1\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=A%20natural%20history%20of%20botanical%20therapeutics&amp;journal=Metabolism&amp;doi=10.1016%2Fj.metabol.2008.03.001&amp;volume=57&amp;pages=S3-S9&amp;publication_year=2008&amp;author=Schmidt%2CB\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR2\">Wright, G. D. Unlocking the potential of natural products in drug discovery. Microb. Biotechnol. 12, 55\u201357 (2019).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1111\/1751-7915.13351\" data-track-item_id=\"10.1111\/1751-7915.13351\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1111%2F1751-7915.13351\" aria-label=\"Article reference 2\" data-doi=\"10.1111\/1751-7915.13351\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC1cXis1SrurfM\" aria-label=\"CAS reference 2\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=30565871\" aria-label=\"PubMed reference 2\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 2\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Unlocking%20the%20potential%20of%20natural%20products%20in%20drug%20discovery&amp;journal=Microb.%20Biotechnol.&amp;doi=10.1111%2F1751-7915.13351&amp;volume=12&amp;pages=55-57&amp;publication_year=2019&amp;author=Wright%2CGD\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR3\">Schloss, P. D. &amp; Handelsman, J. Metagenomics for studying unculturable microorganisms: cutting the Gordian knot. Genome Biol. 6, 229 (2005).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"noopener nofollow\" data-track-label=\"10.1186\/gb-2005-6-8-229\" data-track-item_id=\"10.1186\/gb-2005-6-8-229\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/link.springer.com\/doi\/10.1186\/gb-2005-6-8-229\" aria-label=\"Article reference 3\" data-doi=\"10.1186\/gb-2005-6-8-229\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=16086859\" aria-label=\"PubMed reference 3\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC1273625\" aria-label=\"PubMed Central reference 3\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 3\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Metagenomics%20for%20studying%20unculturable%20microorganisms%3A%20cutting%20the%20Gordian%20knot&amp;journal=Genome%20Biol.&amp;doi=10.1186%2Fgb-2005-6-8-229&amp;volume=6&amp;publication_year=2005&amp;author=Schloss%2CPD&amp;author=Handelsman%2CJ\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR4\">Han, M., Yang, P., Zhou, H., Li, H. &amp; Ning, K. Metagenomics and Single-Cell Omics Data Analysis for Human Microbiome Research. in Translational Biomedical Informatics: A. Precision Medicine Perspective (eds Shen, B., Tang, H. &amp; Jiang, X.) 117\u2013137 <a href=\"https:\/\/doi.org\/10.1007\/978-981-10-1503-8_6\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.1007\/978-981-10-1503-8_6\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.1007\/978-981-10-1503-8_6<\/a>. (Springer, Singapore, 2016).<\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR5\">Nowrotek, M., Ja\u0142owiecki, \u0141, Harnisz, M. &amp; P\u0142aza, G. A. Culturomics and metagenomics: In understanding of environmental resistome. Front. Environ. Sci. Eng. 13, 40 (2019).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"noopener nofollow\" data-track-label=\"10.1007\/s11783-019-1121-8\" data-track-item_id=\"10.1007\/s11783-019-1121-8\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/link.springer.com\/doi\/10.1007\/s11783-019-1121-8\" aria-label=\"Article reference 5\" data-doi=\"10.1007\/s11783-019-1121-8\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 5\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Culturomics%20and%20metagenomics%3A%20In%20understanding%20of%20environmental%20resistome&amp;journal=Front.%20Environ.%20Sci.%20Eng.&amp;doi=10.1007%2Fs11783-019-1121-8&amp;volume=13&amp;publication_year=2019&amp;author=Nowrotek%2CM&amp;author=Ja%C5%82owiecki%2C%C5%81&amp;author=Harnisz%2CM&amp;author=P%C5%82aza%2CGA\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR6\">Keller, N. P., Turner, G. &amp; Bennett, J. W. Fungal secondary metabolism \u2014 from biochemistry to genomics. Nat. Rev. Microbiol. 3, 937\u2013947 (2005).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1038\/nrmicro1286\" data-track-item_id=\"10.1038\/nrmicro1286\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1038%2Fnrmicro1286\" aria-label=\"Article reference 6\" data-doi=\"10.1038\/nrmicro1286\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DC%2BD2MXht1OnsLbF\" aria-label=\"CAS reference 6\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=16322742\" aria-label=\"PubMed reference 6\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 6\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Fungal%20secondary%20metabolism%20%E2%80%94%20from%20biochemistry%20to%20genomics&amp;journal=Nat.%20Rev.%20Microbiol.&amp;doi=10.1038%2Fnrmicro1286&amp;volume=3&amp;pages=937-947&amp;publication_year=2005&amp;author=Keller%2CNP&amp;author=Turner%2CG&amp;author=Bennett%2CJW\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR7\">Bentley, S. D. et al. Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2). Nature 417, 141\u2013147 (2002).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1038\/417141a\" data-track-item_id=\"10.1038\/417141a\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1038%2F417141a\" aria-label=\"Article reference 7\" data-doi=\"10.1038\/417141a\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=12000953\" aria-label=\"PubMed reference 7\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 7\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Complete%20genome%20sequence%20of%20the%20model%20actinomycete%20Streptomyces%20coelicolor%20A3%282%29&amp;journal=Nature&amp;doi=10.1038%2F417141a&amp;volume=417&amp;pages=141-147&amp;publication_year=2002&amp;author=Bentley%2CSD\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR8\">\u014cmura, S. et al. Genome sequence of an industrial microorganism Streptomyces avermitilis: Deducing the ability of producing secondary metabolites. Proc. Natl. Acad. Sci. 98, 12215\u201312220 (2001).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1073\/pnas.211433198\" data-track-item_id=\"10.1073\/pnas.211433198\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1073%2Fpnas.211433198\" aria-label=\"Article reference 8\" data-doi=\"10.1073\/pnas.211433198\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=11572948\" aria-label=\"PubMed reference 8\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC59794\" aria-label=\"PubMed Central reference 8\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 8\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Genome%20sequence%20of%20an%20industrial%20microorganism%20Streptomyces%20avermitilis%3A%20Deducing%20the%20ability%20of%20producing%20secondary%20metabolites&amp;journal=Proc.%20Natl.%20Acad.%20Sci.&amp;doi=10.1073%2Fpnas.211433198&amp;volume=98&amp;pages=12215-12220&amp;publication_year=2001&amp;author=%C5%8Cmura%2CS\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR9\">Almeida, A. et al. A unified catalog of 204,938 reference genomes from the human gut microbiome. Nat. Biotechnol. 39, 105\u2013114 (2021).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1038\/s41587-020-0603-3\" data-track-item_id=\"10.1038\/s41587-020-0603-3\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1038%2Fs41587-020-0603-3\" aria-label=\"Article reference 9\" data-doi=\"10.1038\/s41587-020-0603-3\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB3cXhsVWgtL%2FN\" aria-label=\"CAS reference 9\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=32690973\" aria-label=\"PubMed reference 9\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 9\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=A%20unified%20catalog%20of%20204%2C938%20reference%20genomes%20from%20the%20human%20gut%20microbiome&amp;journal=Nat.%20Biotechnol.&amp;doi=10.1038%2Fs41587-020-0603-3&amp;volume=39&amp;pages=105-114&amp;publication_year=2021&amp;author=Almeida%2CA\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR10\">Li, J. et al. An integrated catalog of reference genes in the human gut microbiome. Nat. Biotechnol. 32, 834\u2013841 (2014).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1038\/nbt.2942\" data-track-item_id=\"10.1038\/nbt.2942\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1038%2Fnbt.2942\" aria-label=\"Article reference 10\" data-doi=\"10.1038\/nbt.2942\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC2cXhtFSlsLjP\" aria-label=\"CAS reference 10\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=24997786\" aria-label=\"PubMed reference 10\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 10\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=An%20integrated%20catalog%20of%20reference%20genes%20in%20the%20human%20gut%20microbiome&amp;journal=Nat.%20Biotechnol.&amp;doi=10.1038%2Fnbt.2942&amp;volume=32&amp;pages=834-841&amp;publication_year=2014&amp;author=Li%2CJ\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR11\">Drula, E. et al. The carbohydrate-active enzyme database: functions and literature. Nucleic Acids Res. 50, D571\u2013D577 (2022).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1093\/nar\/gkab1045\" data-track-item_id=\"10.1093\/nar\/gkab1045\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1093%2Fnar%2Fgkab1045\" aria-label=\"Article reference 11\" data-doi=\"10.1093\/nar\/gkab1045\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB38Xis1ChtLY%3D\" aria-label=\"CAS reference 11\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=34850161\" aria-label=\"PubMed reference 11\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8728194\" aria-label=\"PubMed Central reference 11\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 11\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=The%20carbohydrate-active%20enzyme%20database%3A%20functions%20and%20literature&amp;journal=Nucleic%20Acids%20Res.&amp;doi=10.1093%2Fnar%2Fgkab1045&amp;volume=50&amp;pages=D571-D577&amp;publication_year=2022&amp;author=Drula%2CE\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR12\">Caspi, R. et al. The MetaCyc database of metabolic pathways and enzymes &#8211; a 2019 update. Nucleic Acids Res. 48, D445\u2013D453 (2020).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1093\/nar\/gkz862\" data-track-item_id=\"10.1093\/nar\/gkz862\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1093%2Fnar%2Fgkz862\" aria-label=\"Article reference 12\" data-doi=\"10.1093\/nar\/gkz862\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB3cXhslWlt77I\" aria-label=\"CAS reference 12\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=31586394\" aria-label=\"PubMed reference 12\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6943030\" aria-label=\"PubMed Central reference 12\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 12\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=The%20MetaCyc%20database%20of%20metabolic%20pathways%20and%20enzymes%20-%20a%202019%20update&amp;journal=Nucleic%20Acids%20Res.&amp;doi=10.1093%2Fnar%2Fgkz862&amp;volume=48&amp;pages=D445-D453&amp;publication_year=2020&amp;author=Caspi%2CR\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR13\">Newman, D. J., Cragg, G. M. &amp; Snader, K. M. The influence of natural products upon drug discovery. Nat. Prod. Rep. 17, 215\u2013234 (2000).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1039\/a902202c\" data-track-item_id=\"10.1039\/a902202c\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1039%2Fa902202c\" aria-label=\"Article reference 13\" data-doi=\"10.1039\/a902202c\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DC%2BD3cXjt1GrsbY%3D\" aria-label=\"CAS reference 13\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=10888010\" aria-label=\"PubMed reference 13\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 13\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=The%20influence%20of%20natural%20products%20upon%20drug%20discovery&amp;journal=Nat.%20Prod.%20Rep.&amp;doi=10.1039%2Fa902202c&amp;volume=17&amp;pages=215-234&amp;publication_year=2000&amp;author=Newman%2CDJ&amp;author=Cragg%2CGM&amp;author=Snader%2CKM\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR14\">Newman, D. J., Cragg, G. M., Holbeck, S. &amp; Sausville, E. A. Natural products and derivatives as leads to cell cycle pathway targets in cancer chemotherapy. Curr. Cancer Drug Targets 2, 279\u2013308.<\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR15\">Sparks, T. C., Sparks, J. M. &amp; Duke, S. O. Natural product-based crop protection compounds\u2500origins and future prospects. J. Agric. Food Chem. 71, 2259\u20132269 (2023).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1021\/acs.jafc.2c06938\" data-track-item_id=\"10.1021\/acs.jafc.2c06938\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1021%2Facs.jafc.2c06938\" aria-label=\"Article reference 15\" data-doi=\"10.1021\/acs.jafc.2c06938\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB3sXhs1GnurY%3D\" aria-label=\"CAS reference 15\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=36693160\" aria-label=\"PubMed reference 15\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 15\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Natural%20product-based%20crop%20protection%20compounds%E2%94%80origins%20and%20future%20prospects&amp;journal=J.%20Agric.%20Food%20Chem.&amp;doi=10.1021%2Facs.jafc.2c06938&amp;volume=71&amp;pages=2259-2269&amp;publication_year=2023&amp;author=Sparks%2CTC&amp;author=Sparks%2CJM&amp;author=Duke%2CSO\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR16\">Newman, D. J. &amp; Cragg, G. M. Natural products as sources of new drugs over the nearly four decades from 01\/1981 to 09\/2019. J. Nat. Prod. 83, 770\u2013803 (2020).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1021\/acs.jnatprod.9b01285\" data-track-item_id=\"10.1021\/acs.jnatprod.9b01285\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1021%2Facs.jnatprod.9b01285\" aria-label=\"Article reference 16\" data-doi=\"10.1021\/acs.jnatprod.9b01285\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB3cXks1Cmsrw%3D\" aria-label=\"CAS reference 16\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=32162523\" aria-label=\"PubMed reference 16\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 16\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Natural%20products%20as%20sources%20of%20new%20drugs%20over%20the%20nearly%20four%20decades%20from%2001%2F1981%20to%2009%2F2019&amp;journal=J.%20Nat.%20Prod.&amp;doi=10.1021%2Facs.jnatprod.9b01285&amp;volume=83&amp;pages=770-803&amp;publication_year=2020&amp;author=Newman%2CDJ&amp;author=Cragg%2CGM\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR17\">Katz, L. &amp; Baltz, R. H. Natural product discovery: past, present, and future. J. Ind. Microbiol. Biotechnol. 43, 155\u2013176 (2016).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"noopener nofollow\" data-track-label=\"10.1007\/s10295-015-1723-5\" data-track-item_id=\"10.1007\/s10295-015-1723-5\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/link.springer.com\/doi\/10.1007\/s10295-015-1723-5\" aria-label=\"Article reference 17\" data-doi=\"10.1007\/s10295-015-1723-5\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC28XjtFKhug%3D%3D\" aria-label=\"CAS reference 17\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=26739136\" aria-label=\"PubMed reference 17\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 17\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Natural%20product%20discovery%3A%20past%2C%20present%2C%20and%20future&amp;journal=J.%20Ind.%20Microbiol.%20Biotechnol.&amp;doi=10.1007%2Fs10295-015-1723-5&amp;volume=43&amp;pages=155-176&amp;publication_year=2016&amp;author=Katz%2CL&amp;author=Baltz%2CRH\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR18\">Elshafie, H. S., Camele, I. &amp; Mohamed, A. A. A Comprehensive review on the biological, agricultural and pharmaceutical properties of secondary metabolites based-plant origin. Int. J. Mol. Sci. 24, 3266 (2023).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.3390\/ijms24043266\" data-track-item_id=\"10.3390\/ijms24043266\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.3390%2Fijms24043266\" aria-label=\"Article reference 18\" data-doi=\"10.3390\/ijms24043266\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB3sXksFOhurg%3D\" aria-label=\"CAS reference 18\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=36834673\" aria-label=\"PubMed reference 18\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9959544\" aria-label=\"PubMed Central reference 18\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 18\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=A%20Comprehensive%20review%20on%20the%20biological%2C%20agricultural%20and%20pharmaceutical%20properties%20of%20secondary%20metabolites%20based-plant%20origin&amp;journal=Int.%20J.%20Mol.%20Sci.&amp;doi=10.3390%2Fijms24043266&amp;volume=24&amp;publication_year=2023&amp;author=Elshafie%2CHS&amp;author=Camele%2CI&amp;author=Mohamed%2CAA\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR19\">Karnwal, A. et al. Microbial biosurfactant as an alternate to chemical surfactants for application in cosmetics industries in personal and skin care products: a critical review. BioMed. Res. Int. 2023, 2375223 (2023).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1155\/2023\/2375223\" data-track-item_id=\"10.1155\/2023\/2375223\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1155%2F2023%2F2375223\" aria-label=\"Article reference 19\" data-doi=\"10.1155\/2023\/2375223\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=37090190\" aria-label=\"PubMed reference 19\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC10118887\" aria-label=\"PubMed Central reference 19\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 19\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Microbial%20biosurfactant%20as%20an%20alternate%20to%20chemical%20surfactants%20for%20application%20in%20cosmetics%20industries%20in%20personal%20and%20skin%20care%20products%3A%20a%20critical%20review&amp;journal=BioMed.%20Res.%20Int.&amp;doi=10.1155%2F2023%2F2375223&amp;volume=2023&amp;publication_year=2023&amp;author=Karnwal%2CA\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR20\">Dinglasan, J. L. N., Otani, H., Doering, D. T., Udwary, D. &amp; Mouncey, N. J. Microbial secondary metabolites: advancements to accelerate discovery towards application. Nat. Rev. Microbiol. 23, 338\u2013354 (2025).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1038\/s41579-024-01141-y\" data-track-item_id=\"10.1038\/s41579-024-01141-y\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1038%2Fs41579-024-01141-y\" aria-label=\"Article reference 20\" data-doi=\"10.1038\/s41579-024-01141-y\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB2MXhslKntrc%3D\" aria-label=\"CAS reference 20\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=39824928\" aria-label=\"PubMed reference 20\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 20\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Microbial%20secondary%20metabolites%3A%20advancements%20to%20accelerate%20discovery%20towards%20application&amp;journal=Nat.%20Rev.%20Microbiol.&amp;doi=10.1038%2Fs41579-024-01141-y&amp;volume=23&amp;pages=338-354&amp;publication_year=2025&amp;author=Dinglasan%2CJLN&amp;author=Otani%2CH&amp;author=Doering%2CDT&amp;author=Udwary%2CD&amp;author=Mouncey%2CNJ\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR21\">Yuzawa, S., Keasling, J. D. &amp; Katz, L. Bio-based production of fuels and industrial chemicals by repurposing antibiotic-producing type I modular polyketide synthases: opportunities and challenges. J. Antibiot. 70, 378\u2013385 (2017).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1038\/ja.2016.136\" data-track-item_id=\"10.1038\/ja.2016.136\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1038%2Fja.2016.136\" aria-label=\"Article reference 21\" data-doi=\"10.1038\/ja.2016.136\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC2sXltl2rtbs%3D\" aria-label=\"CAS reference 21\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 21\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Bio-based%20production%20of%20fuels%20and%20industrial%20chemicals%20by%20repurposing%20antibiotic-producing%20type%20I%20modular%20polyketide%20synthases%3A%20opportunities%20and%20challenges&amp;journal=J.%20Antibiot.&amp;doi=10.1038%2Fja.2016.136&amp;volume=70&amp;pages=378-385&amp;publication_year=2017&amp;author=Yuzawa%2CS&amp;author=Keasling%2CJD&amp;author=Katz%2CL\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR22\">Chen, X. &amp; Li, B. Analysis of co-localized biosynthetic gene clusters identifies a membrane-permeabilizing natural product. J. Nat. Prod. 87, 1694\u20131703 (2024).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1021\/acs.jnatprod.3c01231\" data-track-item_id=\"10.1021\/acs.jnatprod.3c01231\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1021%2Facs.jnatprod.3c01231\" aria-label=\"Article reference 22\" data-doi=\"10.1021\/acs.jnatprod.3c01231\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB2cXhsVemurbM\" aria-label=\"CAS reference 22\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=38949271\" aria-label=\"PubMed reference 22\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC12131182\" aria-label=\"PubMed Central reference 22\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 22\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Analysis%20of%20co-localized%20biosynthetic%20gene%20clusters%20identifies%20a%20membrane-permeabilizing%20natural%20product&amp;journal=J.%20Nat.%20Prod.&amp;doi=10.1021%2Facs.jnatprod.3c01231&amp;volume=87&amp;pages=1694-1703&amp;publication_year=2024&amp;author=Chen%2CX&amp;author=Li%2CB\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR23\">Kwon, M. J. et al. Beyond the biosynthetic gene cluster paradigm: genome-wide coexpression networks connect clustered and unclustered transcription factors to secondary metabolic pathways. Microbiol. Spectr. 9, e00898\u201321 (2021).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1128\/Spectrum.00898-21\" data-track-item_id=\"10.1128\/Spectrum.00898-21\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1128%2FSpectrum.00898-21\" aria-label=\"Article reference 23\" data-doi=\"10.1128\/Spectrum.00898-21\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB3MXisFaktbzE\" aria-label=\"CAS reference 23\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=34523946\" aria-label=\"PubMed reference 23\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8557879\" aria-label=\"PubMed Central reference 23\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 23\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Beyond%20the%20biosynthetic%20gene%20cluster%20paradigm%3A%20genome-wide%20coexpression%20networks%20connect%20clustered%20and%20unclustered%20transcription%20factors%20to%20secondary%20metabolic%20pathways&amp;journal=Microbiol.%20Spectr.&amp;doi=10.1128%2FSpectrum.00898-21&amp;volume=9&amp;pages=e00898-21&amp;publication_year=2021&amp;author=Kwon%2CMJ\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR24\">Medema, M. H. et al. Minimum Information about a Biosynthetic Gene cluster. Nat. Chem. Biol. 11, 625\u2013631 (2015).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1038\/nchembio.1890\" data-track-item_id=\"10.1038\/nchembio.1890\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1038%2Fnchembio.1890\" aria-label=\"Article reference 24\" data-doi=\"10.1038\/nchembio.1890\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC2MXhtlKntrjN\" aria-label=\"CAS reference 24\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=26284661\" aria-label=\"PubMed reference 24\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5714517\" aria-label=\"PubMed Central reference 24\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 24\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Minimum%20Information%20about%20a%20Biosynthetic%20Gene%20cluster&amp;journal=Nat.%20Chem.%20Biol.&amp;doi=10.1038%2Fnchembio.1890&amp;volume=11&amp;pages=625-631&amp;publication_year=2015&amp;author=Medema%2CMH\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR25\">Crits-Christoph, A., Bhattacharya, N., Olm, M. R., Song, Y. S. &amp; Banfield, J. F. Transporter genes in biosynthetic gene clusters predict metabolite characteristics and siderophore activity. Genome Res. 31, 239\u2013250 (2021).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1101\/gr.268169.120\" data-track-item_id=\"10.1101\/gr.268169.120\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1101%2Fgr.268169.120\" aria-label=\"Article reference 25\" data-doi=\"10.1101\/gr.268169.120\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB2cXitFyqtbvM\" aria-label=\"CAS reference 25\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=33361114\" aria-label=\"PubMed reference 25\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 25\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Transporter%20genes%20in%20biosynthetic%20gene%20clusters%20predict%20metabolite%20characteristics%20and%20siderophore%20activity&amp;journal=Genome%20Res.&amp;doi=10.1101%2Fgr.268169.120&amp;volume=31&amp;pages=239-250&amp;publication_year=2021&amp;author=Crits-Christoph%2CA&amp;author=Bhattacharya%2CN&amp;author=Olm%2CMR&amp;author=Song%2CYS&amp;author=Banfield%2CJF\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR26\">Medema, M. H. &amp; Fischbach, M. A. Computational approaches to natural product discovery. Nat. Chem. Biol. 11, 639\u2013648 (2015).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1038\/nchembio.1884\" data-track-item_id=\"10.1038\/nchembio.1884\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1038%2Fnchembio.1884\" aria-label=\"Article reference 26\" data-doi=\"10.1038\/nchembio.1884\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC2MXhtlKntrjP\" aria-label=\"CAS reference 26\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=26284671\" aria-label=\"PubMed reference 26\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5024737\" aria-label=\"PubMed Central reference 26\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 26\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Computational%20approaches%20to%20natural%20product%20discovery&amp;journal=Nat.%20Chem.%20Biol.&amp;doi=10.1038%2Fnchembio.1884&amp;volume=11&amp;pages=639-648&amp;publication_year=2015&amp;author=Medema%2CMH&amp;author=Fischbach%2CMA\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR27\">Atanasov, A. G., Zotchev, S. B., Dirsch, V. M. &amp; Supuran, C. T. Natural products in drug discovery: advances and opportunities. Nat. Rev. Drug Discov. 20, 200\u2013216 (2021).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1038\/s41573-020-00114-z\" data-track-item_id=\"10.1038\/s41573-020-00114-z\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1038%2Fs41573-020-00114-z\" aria-label=\"Article reference 27\" data-doi=\"10.1038\/s41573-020-00114-z\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB3MXisV2ht74%3D\" aria-label=\"CAS reference 27\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=33510482\" aria-label=\"PubMed reference 27\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7841765\" aria-label=\"PubMed Central reference 27\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 27\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Natural%20products%20in%20drug%20discovery%3A%20advances%20and%20opportunities&amp;journal=Nat.%20Rev.%20Drug%20Discov.&amp;doi=10.1038%2Fs41573-020-00114-z&amp;volume=20&amp;pages=200-216&amp;publication_year=2021&amp;author=Atanasov%2CAG&amp;author=Zotchev%2CSB&amp;author=Dirsch%2CVM&amp;author=Supuran%2CCT\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR28\">Payne, D. J., Gwynn, M. N., Holmes, D. J. &amp; Pompliano, D. L. Drugs for bad bugs: confronting the challenges of antibacterial discovery. Nat. Rev. Drug Discov. 6, 29\u201340 (2007).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1038\/nrd2201\" data-track-item_id=\"10.1038\/nrd2201\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1038%2Fnrd2201\" aria-label=\"Article reference 28\" data-doi=\"10.1038\/nrd2201\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DC%2BD28XhtlGktbfM\" aria-label=\"CAS reference 28\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=17159923\" aria-label=\"PubMed reference 28\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 28\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Drugs%20for%20bad%20bugs%3A%20confronting%20the%20challenges%20of%20antibacterial%20discovery&amp;journal=Nat.%20Rev.%20Drug%20Discov.&amp;doi=10.1038%2Fnrd2201&amp;volume=6&amp;pages=29-40&amp;publication_year=2007&amp;author=Payne%2CDJ&amp;author=Gwynn%2CMN&amp;author=Holmes%2CDJ&amp;author=Pompliano%2CDL\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR29\">Hoskisson, P. A. &amp; Seipke, R. F. Cryptic or Silent? The Known Unknowns, Unknown Knowns, and Unknown Unknowns of Secondary Metabolism. mBio 11, <a href=\"https:\/\/doi.org\/10.1128\/mbio.02642-20\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.1128\/mbio.02642-20\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.1128\/mbio.02642-20<\/a> (2020).<\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR30\">Kerkhoven, E. J. Advances in constraint-based models: methods for improved predictive power based on resource allocation constraints. Curr. Opin. Microbiol. 68, 102168 (2022).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1016\/j.mib.2022.102168\" data-track-item_id=\"10.1016\/j.mib.2022.102168\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1016%2Fj.mib.2022.102168\" aria-label=\"Article reference 30\" data-doi=\"10.1016\/j.mib.2022.102168\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=35691074\" aria-label=\"PubMed reference 30\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 30\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Advances%20in%20constraint-based%20models%3A%20methods%20for%20improved%20predictive%20power%20based%20on%20resource%20allocation%20constraints&amp;journal=Curr.%20Opin.%20Microbiol.&amp;doi=10.1016%2Fj.mib.2022.102168&amp;volume=68&amp;publication_year=2022&amp;author=Kerkhoven%2CEJ\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR31\">Rutledge, P. J. &amp; Challis, G. L. Discovery of microbial natural products by activation of silent biosynthetic gene clusters. Nat. Rev. Microbiol. 13, 509\u2013523 (2015).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1038\/nrmicro3496\" data-track-item_id=\"10.1038\/nrmicro3496\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1038%2Fnrmicro3496\" aria-label=\"Article reference 31\" data-doi=\"10.1038\/nrmicro3496\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC2MXhtFaitr3O\" aria-label=\"CAS reference 31\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=26119570\" aria-label=\"PubMed reference 31\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 31\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Discovery%20of%20microbial%20natural%20products%20by%20activation%20of%20silent%20biosynthetic%20gene%20clusters&amp;journal=Nat.%20Rev.%20Microbiol.&amp;doi=10.1038%2Fnrmicro3496&amp;volume=13&amp;pages=509-523&amp;publication_year=2015&amp;author=Rutledge%2CPJ&amp;author=Challis%2CGL\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR32\">Zhang, M. M. et al. CRISPR\u2013Cas9 strategy for activation of silent Streptomyces biosynthetic gene clusters. Nat. Chem. Biol. 13, 607\u2013609 (2017).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1038\/nchembio.2341\" data-track-item_id=\"10.1038\/nchembio.2341\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1038%2Fnchembio.2341\" aria-label=\"Article reference 32\" data-doi=\"10.1038\/nchembio.2341\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC2sXlslyhtLs%3D\" aria-label=\"CAS reference 32\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 32\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=CRISPR%E2%80%93Cas9%20strategy%20for%20activation%20of%20silent%20Streptomyces%20biosynthetic%20gene%20clusters&amp;journal=Nat.%20Chem.%20Biol.&amp;doi=10.1038%2Fnchembio.2341&amp;volume=13&amp;pages=607-609&amp;publication_year=2017&amp;author=Zhang%2CMM\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR33\">Poppeliers, J., Boon, M., De Mey, M., Masschelein, J. &amp; Lavigne, R. Non-model bacteria as platforms for endogenous gene expression in synthetic biology. Nat. Rev. Bioeng. 1\u201315 <a href=\"https:\/\/doi.org\/10.1038\/s44222-025-00354-x\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.1038\/s44222-025-00354-x\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.1038\/s44222-025-00354-x<\/a> (2025).<\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR34\">Kadjo, A. E. &amp; Eust\u00e1quio, A. S. Bacterial natural product discovery by heterologous expression. J. Ind. Microbiol. Biotechnol. 50, kuad044 (2023).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1093\/jimb\/kuad044\" data-track-item_id=\"10.1093\/jimb\/kuad044\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1093%2Fjimb%2Fkuad044\" aria-label=\"Article reference 34\" data-doi=\"10.1093\/jimb\/kuad044\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB2cXhtVShsLk%3D\" aria-label=\"CAS reference 34\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=38052428\" aria-label=\"PubMed reference 34\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC10727000\" aria-label=\"PubMed Central reference 34\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 34\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Bacterial%20natural%20product%20discovery%20by%20heterologous%20expression&amp;journal=J.%20Ind.%20Microbiol.%20Biotechnol.&amp;doi=10.1093%2Fjimb%2Fkuad044&amp;volume=50&amp;publication_year=2023&amp;author=Kadjo%2CAE&amp;author=Eust%C3%A1quio%2CAS\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR35\">Maeda, H. A. Evolutionary diversification of primary metabolism and its contribution to plant chemical diversity. Front. Plant Sci. 10, 881 (2019).<\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR36\">Sanchez, S. &amp; Demain, A. L. Metabolic regulation and overproduction of primary metabolites. Microb. Biotechnol. 1, 283\u2013319 (2008).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1111\/j.1751-7915.2007.00015.x\" data-track-item_id=\"10.1111\/j.1751-7915.2007.00015.x\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1111%2Fj.1751-7915.2007.00015.x\" aria-label=\"Article reference 36\" data-doi=\"10.1111\/j.1751-7915.2007.00015.x\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DC%2BD1cXhsV2hs77M\" aria-label=\"CAS reference 36\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=21261849\" aria-label=\"PubMed reference 36\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3815394\" aria-label=\"PubMed Central reference 36\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 36\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Metabolic%20regulation%20and%20overproduction%20of%20primary%20metabolites&amp;journal=Microb.%20Biotechnol.&amp;doi=10.1111%2Fj.1751-7915.2007.00015.x&amp;volume=1&amp;pages=283-319&amp;publication_year=2008&amp;author=Sanchez%2CS&amp;author=Demain%2CAL\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR37\">Ivanisevic, J. et al. Biochemical Trade-Offs: Evidence for Ecologically Linked Secondary Metabolism of the Sponge Oscarella balibaloi. PLOS ONE 6, e28059 (2011).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1371\/journal.pone.0028059\" data-track-item_id=\"10.1371\/journal.pone.0028059\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1371%2Fjournal.pone.0028059\" aria-label=\"Article reference 37\" data-doi=\"10.1371\/journal.pone.0028059\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC3MXhs1ensLzI\" aria-label=\"CAS reference 37\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=22132209\" aria-label=\"PubMed reference 37\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3223221\" aria-label=\"PubMed Central reference 37\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 37\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Biochemical%20Trade-Offs%3A%20Evidence%20for%20Ecologically%20Linked%20Secondary%20Metabolism%20of%20the%20Sponge%20Oscarella%20balibaloi&amp;journal=PLOS%20ONE&amp;doi=10.1371%2Fjournal.pone.0028059&amp;volume=6&amp;publication_year=2011&amp;author=Ivanisevic%2CJ\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR38\">Brand, A. &amp; Tissier, A. Control of resource allocation between primary and specialized metabolism in glandular trichomes. Curr. Opin. Plant Biol. 66, 102172 (2022).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1016\/j.pbi.2022.102172\" data-track-item_id=\"10.1016\/j.pbi.2022.102172\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1016%2Fj.pbi.2022.102172\" aria-label=\"Article reference 38\" data-doi=\"10.1016\/j.pbi.2022.102172\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB38Xht1Sgu7vJ\" aria-label=\"CAS reference 38\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=35144142\" aria-label=\"PubMed reference 38\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 38\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Control%20of%20resource%20allocation%20between%20primary%20and%20specialized%20metabolism%20in%20glandular%20trichomes&amp;journal=Curr.%20Opin.%20Plant%20Biol.&amp;doi=10.1016%2Fj.pbi.2022.102172&amp;volume=66&amp;publication_year=2022&amp;author=Brand%2CA&amp;author=Tissier%2CA\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR39\">Ribeiro Monteiro, S., Kerdel, Y., Gathot, J. &amp; Rigali, S. The Transcriptional Architecture of Bacterial Biosynthetic Gene Clusters. J. Nat. Prod. 88, 1772\u20131780 (2025).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1021\/acs.jnatprod.5c00529\" data-track-item_id=\"10.1021\/acs.jnatprod.5c00529\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1021%2Facs.jnatprod.5c00529\" aria-label=\"Article reference 39\" data-doi=\"10.1021\/acs.jnatprod.5c00529\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB2MXhsFOnurnE\" aria-label=\"CAS reference 39\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=40569150\" aria-label=\"PubMed reference 39\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 39\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=The%20Transcriptional%20Architecture%20of%20Bacterial%20Biosynthetic%20Gene%20Clusters&amp;journal=J.%20Nat.%20Prod.&amp;doi=10.1021%2Facs.jnatprod.5c00529&amp;volume=88&amp;pages=1772-1780&amp;publication_year=2025&amp;author=Ribeiro%20Monteiro%2CS&amp;author=Kerdel%2CY&amp;author=Gathot%2CJ&amp;author=Rigali%2CS\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR40\">Bruggeman, F. J., Planqu\u00e9, R., Molenaar, D. &amp; Teusink, B. Searching for principles of microbial physiology. FEMS Microbiol. Rev. 44, 821\u2013844 (2020).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1093\/femsre\/fuaa034\" data-track-item_id=\"10.1093\/femsre\/fuaa034\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1093%2Ffemsre%2Ffuaa034\" aria-label=\"Article reference 40\" data-doi=\"10.1093\/femsre\/fuaa034\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB3MXhtlWgur7J\" aria-label=\"CAS reference 40\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=33099619\" aria-label=\"PubMed reference 40\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7685786\" aria-label=\"PubMed Central reference 40\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 40\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Searching%20for%20principles%20of%20microbial%20physiology&amp;journal=FEMS%20Microbiol.%20Rev.&amp;doi=10.1093%2Ffemsre%2Ffuaa034&amp;volume=44&amp;pages=821-844&amp;publication_year=2020&amp;author=Bruggeman%2CFJ&amp;author=Planqu%C3%A9%2CR&amp;author=Molenaar%2CD&amp;author=Teusink%2CB\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR41\">Galm, U. &amp; Shen, B. Expression of biosynthetic gene clusters in heterologous hosts for natural product production and combinatorial biosynthesis. Expert Opin. Drug Discov. 1, 409\u2013437 (2006).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1517\/17460441.1.5.409\" data-track-item_id=\"10.1517\/17460441.1.5.409\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1517%2F17460441.1.5.409\" aria-label=\"Article reference 41\" data-doi=\"10.1517\/17460441.1.5.409\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DC%2BD28Xht1emtbnI\" aria-label=\"CAS reference 41\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=23495943\" aria-label=\"PubMed reference 41\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 41\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Expression%20of%20biosynthetic%20gene%20clusters%20in%20heterologous%20hosts%20for%20natural%20product%20production%20and%20combinatorial%20biosynthesis&amp;journal=Expert%20Opin.%20Drug%20Discov.&amp;doi=10.1517%2F17460441.1.5.409&amp;volume=1&amp;pages=409-437&amp;publication_year=2006&amp;author=Galm%2CU&amp;author=Shen%2CB\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR42\">Covington, B. C., Xu, F. &amp; Seyedsayamdost, M. R. A natural product chemist\u2019s guide to unlocking silent biosynthetic gene clusters. Annu. Rev. Biochem. 90, 763\u2013788 (2021).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1146\/annurev-biochem-081420-102432\" data-track-item_id=\"10.1146\/annurev-biochem-081420-102432\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1146%2Fannurev-biochem-081420-102432\" aria-label=\"Article reference 42\" data-doi=\"10.1146\/annurev-biochem-081420-102432\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB3MXos1CgtbY%3D\" aria-label=\"CAS reference 42\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=33848426\" aria-label=\"PubMed reference 42\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9148385\" aria-label=\"PubMed Central reference 42\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 42\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=A%20natural%20product%20chemist%E2%80%99s%20guide%20to%20unlocking%20silent%20biosynthetic%20gene%20clusters&amp;journal=Annu.%20Rev.%20Biochem.&amp;doi=10.1146%2Fannurev-biochem-081420-102432&amp;volume=90&amp;pages=763-788&amp;publication_year=2021&amp;author=Covington%2CBC&amp;author=Xu%2CF&amp;author=Seyedsayamdost%2CMR\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR43\">Cawood, G. L. &amp; Ton, J. Decoding resilience: ecology, regulation, and evolution of biosynthetic gene clusters. Trends Plant Sci. 30, 185\u2013198 (2025).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1016\/j.tplants.2024.09.008\" data-track-item_id=\"10.1016\/j.tplants.2024.09.008\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1016%2Fj.tplants.2024.09.008\" aria-label=\"Article reference 43\" data-doi=\"10.1016\/j.tplants.2024.09.008\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB2cXitF2nsL%2FP\" aria-label=\"CAS reference 43\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=39393973\" aria-label=\"PubMed reference 43\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 43\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Decoding%20resilience%3A%20ecology%2C%20regulation%2C%20and%20evolution%20of%20biosynthetic%20gene%20clusters&amp;journal=Trends%20Plant%20Sci.&amp;doi=10.1016%2Fj.tplants.2024.09.008&amp;volume=30&amp;pages=185-198&amp;publication_year=2025&amp;author=Cawood%2CGL&amp;author=Ton%2CJ\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR44\">Rigali, S., Anderssen, S., Na\u00f4m\u00e9, A. &amp; van Wezel, G. P. Cracking the regulatory code of biosynthetic gene clusters as a strategy for natural product discovery. Biochem. Pharmacol. 153, 24\u201334 (2018).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1016\/j.bcp.2018.01.007\" data-track-item_id=\"10.1016\/j.bcp.2018.01.007\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1016%2Fj.bcp.2018.01.007\" aria-label=\"Article reference 44\" data-doi=\"10.1016\/j.bcp.2018.01.007\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC1cXmt1Gkuw%3D%3D\" aria-label=\"CAS reference 44\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=29309762\" aria-label=\"PubMed reference 44\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 44\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Cracking%20the%20regulatory%20code%20of%20biosynthetic%20gene%20clusters%20as%20a%20strategy%20for%20natural%20product%20discovery&amp;journal=Biochem.%20Pharmacol.&amp;doi=10.1016%2Fj.bcp.2018.01.007&amp;volume=153&amp;pages=24-34&amp;publication_year=2018&amp;author=Rigali%2CS&amp;author=Anderssen%2CS&amp;author=Na%C3%B4m%C3%A9%2CA&amp;author=Wezel%2CGP\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR45\">Kang, H.-S. &amp; Kim, E.-S. Recent advances in heterologous expression of natural product biosynthetic gene clusters in Streptomyces hosts. Curr. Opin. Biotechnol. 69, 118\u2013127 (2021).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1016\/j.copbio.2020.12.016\" data-track-item_id=\"10.1016\/j.copbio.2020.12.016\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1016%2Fj.copbio.2020.12.016\" aria-label=\"Article reference 45\" data-doi=\"10.1016\/j.copbio.2020.12.016\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB3MXmtVGqsQ%3D%3D\" aria-label=\"CAS reference 45\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=33445072\" aria-label=\"PubMed reference 45\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 45\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Recent%20advances%20in%20heterologous%20expression%20of%20natural%20product%20biosynthetic%20gene%20clusters%20in%20Streptomyces%20hosts&amp;journal=Curr.%20Opin.%20Biotechnol.&amp;doi=10.1016%2Fj.copbio.2020.12.016&amp;volume=69&amp;pages=118-127&amp;publication_year=2021&amp;author=Kang%2CH-S&amp;author=Kim%2CE-S\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR46\">Fern\u00e1ndez-Moreno, M. A., Caballero, J., Hopwood, D. A. &amp; Malpartida, F. The act cluster contains regulatory and antibiotic export genes, direct targets for translational control by the bldA tRNA gene of streptomyces. Cell 66, 769\u2013780 (1991).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1016\/0092-8674(91)90120-N\" data-track-item_id=\"10.1016\/0092-8674(91)90120-N\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1016%2F0092-8674%2891%2990120-N\" aria-label=\"Article reference 46\" data-doi=\"10.1016\/0092-8674(91)90120-N\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=1878971\" aria-label=\"PubMed reference 46\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 46\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=The%20act%20cluster%20contains%20regulatory%20and%20antibiotic%20export%20genes%2C%20direct%20targets%20for%20translational%20control%20by%20the%20bldA%20tRNA%20gene%20of%20streptomyces&amp;journal=Cell&amp;doi=10.1016%2F0092-8674%2891%2990120-N&amp;volume=66&amp;pages=769-780&amp;publication_year=1991&amp;author=Fern%C3%A1ndez-Moreno%2CMA&amp;author=Caballero%2CJ&amp;author=Hopwood%2CDA&amp;author=Malpartida%2CF\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR47\">Arias, P., Fern\u00e1ndez-Moreno, M. A. &amp; Malpartida, F. Characterization of the Pathway-Specific Positive Transcriptional Regulator for Actinorhodin Biosynthesis inStreptomyces coelicolor A3(2) as a DNA-Binding Protein. J. Bacteriol. 181, 6958\u20136968 (1999).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1128\/JB.181.22.6958-6968.1999\" data-track-item_id=\"10.1128\/JB.181.22.6958-6968.1999\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1128%2FJB.181.22.6958-6968.1999\" aria-label=\"Article reference 47\" data-doi=\"10.1128\/JB.181.22.6958-6968.1999\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DyaK1MXnsFSrtbc%3D\" aria-label=\"CAS reference 47\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=10559161\" aria-label=\"PubMed reference 47\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC94170\" aria-label=\"PubMed Central reference 47\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 47\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Characterization%20of%20the%20Pathway-Specific%20Positive%20Transcriptional%20Regulator%20for%20Actinorhodin%20Biosynthesis%20inStreptomyces%20coelicolor%20A3%282%29%20as%20a%20DNA-Binding%20Protein&amp;journal=J.%20Bacteriol.&amp;doi=10.1128%2FJB.181.22.6958-6968.1999&amp;volume=181&amp;pages=6958-6968&amp;publication_year=1999&amp;author=Arias%2CP&amp;author=Fern%C3%A1ndez-Moreno%2CMA&amp;author=Malpartida%2CF\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR48\">Retzlaff, L. &amp; Distler, J. The regulator of streptomycin gene expression, StrR, of Streptomyces griseus is a DNA binding activator protein with multiple recognition sites. Mol. Microbiol. 18, 151\u2013162 (1995).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1111\/j.1365-2958.1995.mmi_18010151.x\" data-track-item_id=\"10.1111\/j.1365-2958.1995.mmi_18010151.x\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1111%2Fj.1365-2958.1995.mmi_18010151.x\" aria-label=\"Article reference 48\" data-doi=\"10.1111\/j.1365-2958.1995.mmi_18010151.x\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:STN:280:DyaK287lsV2nug%3D%3D\" aria-label=\"CAS reference 48\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=8596455\" aria-label=\"PubMed reference 48\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 48\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=The%20regulator%20of%20streptomycin%20gene%20expression%2C%20StrR%2C%20of%20Streptomyces%20griseus%20is%20a%20DNA%20binding%20activator%20protein%20with%20multiple%20recognition%20sites&amp;journal=Mol.%20Microbiol.&amp;doi=10.1111%2Fj.1365-2958.1995.mmi_18010151.x&amp;volume=18&amp;pages=151-162&amp;publication_year=1995&amp;author=Retzlaff%2CL&amp;author=Distler%2CJ\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR49\">Lim, F. Y. et al. Fungal Isocyanide Synthases and Xanthocillin Biosynthesis in Aspergillus fumigatus. mBio 9, <a href=\"https:\/\/doi.org\/10.1128\/mbio.00785-18\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.1128\/mbio.00785-18\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.1128\/mbio.00785-18<\/a> (2018).<\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR50\">Hoskisson, P. A. &amp; Fern\u00e1ndez-Mart\u00ednez, L. T. Regulation of specialised metabolites in Actinobacteria \u2013 expanding the paradigms. Environ. Microbiol. Rep. 10, 231\u2013238 (2018).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1111\/1758-2229.12629\" data-track-item_id=\"10.1111\/1758-2229.12629\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1111%2F1758-2229.12629\" aria-label=\"Article reference 50\" data-doi=\"10.1111\/1758-2229.12629\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=29457705\" aria-label=\"PubMed reference 50\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6001450\" aria-label=\"PubMed Central reference 50\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 50\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Regulation%20of%20specialised%20metabolites%20in%20Actinobacteria%20%E2%80%93%20expanding%20the%20paradigms&amp;journal=Environ.%20Microbiol.%20Rep.&amp;doi=10.1111%2F1758-2229.12629&amp;volume=10&amp;pages=231-238&amp;publication_year=2018&amp;author=Hoskisson%2CPA&amp;author=Fern%C3%A1ndez-Mart%C3%ADnez%2CLT\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR51\">Cuthbertson, L. &amp; Nodwell, J. R. The TetR family of regulators. Microbiol. Mol. Biol. Rev. MMBR 77, 440\u2013475 (2013).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1128\/MMBR.00018-13\" data-track-item_id=\"10.1128\/MMBR.00018-13\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1128%2FMMBR.00018-13\" aria-label=\"Article reference 51\" data-doi=\"10.1128\/MMBR.00018-13\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC3sXhslWhs7jF\" aria-label=\"CAS reference 51\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=24006471\" aria-label=\"PubMed reference 51\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3811609\" aria-label=\"PubMed Central reference 51\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 51\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=The%20TetR%20family%20of%20regulators&amp;journal=Microbiol.%20Mol.%20Biol.%20Rev.%20MMBR&amp;doi=10.1128%2FMMBR.00018-13&amp;volume=77&amp;pages=440-475&amp;publication_year=2013&amp;author=Cuthbertson%2CL&amp;author=Nodwell%2CJR\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR52\">Takano, E. \u03b3-Butyrolactones: Streptomyces signalling molecules regulating antibiotic production and differentiation. Curr. Opin. Microbiol. 9, 287\u2013294 (2006).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1016\/j.mib.2006.04.003\" data-track-item_id=\"10.1016\/j.mib.2006.04.003\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1016%2Fj.mib.2006.04.003\" aria-label=\"Article reference 52\" data-doi=\"10.1016\/j.mib.2006.04.003\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DC%2BD28XltleltLw%3D\" aria-label=\"CAS reference 52\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=16675291\" aria-label=\"PubMed reference 52\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 52\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=%CE%B3-Butyrolactones%3A%20Streptomyces%20signalling%20molecules%20regulating%20antibiotic%20production%20and%20differentiation&amp;journal=Curr.%20Opin.%20Microbiol.&amp;doi=10.1016%2Fj.mib.2006.04.003&amp;volume=9&amp;pages=287-294&amp;publication_year=2006&amp;author=Takano%2CE\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR53\">Takano, E. et al. A bacterial hormone (the SCB1) directly controls the expression of a pathway-specific regulatory gene in the cryptic type I polyketide biosynthetic gene cluster of Streptomyces coelicolor. Mol. Microbiol. 56, 465\u2013479 (2005).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1111\/j.1365-2958.2005.04543.x\" data-track-item_id=\"10.1111\/j.1365-2958.2005.04543.x\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1111%2Fj.1365-2958.2005.04543.x\" aria-label=\"Article reference 53\" data-doi=\"10.1111\/j.1365-2958.2005.04543.x\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DC%2BD2MXjsFWmtLw%3D\" aria-label=\"CAS reference 53\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=15813737\" aria-label=\"PubMed reference 53\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 53\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=A%20bacterial%20hormone%20%28the%20SCB1%29%20directly%20controls%20the%20expression%20of%20a%20pathway-specific%20regulatory%20gene%20in%20the%20cryptic%20type%20I%20polyketide%20biosynthetic%20gene%20cluster%20of%20Streptomyces%20coelicolor&amp;journal=Mol.%20Microbiol.&amp;doi=10.1111%2Fj.1365-2958.2005.04543.x&amp;volume=56&amp;pages=465-479&amp;publication_year=2005&amp;author=Takano%2CE\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR54\">Seipke, R. F., Patrick, E. &amp; Hutchings, M. I. Regulation of antimycin biosynthesis by the orphan ECF RNA polymerase sigma factor \u03c3AntA. PeerJ 2, e253 (2014).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.7717\/peerj.253\" data-track-item_id=\"10.7717\/peerj.253\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.7717%2Fpeerj.253\" aria-label=\"Article reference 54\" data-doi=\"10.7717\/peerj.253\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=24688837\" aria-label=\"PubMed reference 54\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3933326\" aria-label=\"PubMed Central reference 54\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 54\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Regulation%20of%20antimycin%20biosynthesis%20by%20the%20orphan%20ECF%20RNA%20polymerase%20sigma%20factor%20%CF%83AntA&amp;journal=PeerJ&amp;doi=10.7717%2Fpeerj.253&amp;volume=2&amp;publication_year=2014&amp;author=Seipke%2CRF&amp;author=Patrick%2CE&amp;author=Hutchings%2CMI\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR55\">Foulston, L. &amp; Bibb, M. Feed-forward regulation of microbisporicin biosynthesis in Microbispora corallina \u25bf. J. Bacteriol. 193, 3064\u20133071 (2011).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1128\/JB.00250-11\" data-track-item_id=\"10.1128\/JB.00250-11\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1128%2FJB.00250-11\" aria-label=\"Article reference 55\" data-doi=\"10.1128\/JB.00250-11\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC3MXnsFyksb0%3D\" aria-label=\"CAS reference 55\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=21478362\" aria-label=\"PubMed reference 55\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3133186\" aria-label=\"PubMed Central reference 55\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 55\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Feed-forward%20regulation%20of%20microbisporicin%20biosynthesis%20in%20Microbispora%20corallina%20%E2%96%BF&amp;journal=J.%20Bacteriol.&amp;doi=10.1128%2FJB.00250-11&amp;volume=193&amp;pages=3064-3071&amp;publication_year=2011&amp;author=Foulston%2CL&amp;author=Bibb%2CM\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR56\">Lyu, H.-N., Liu, H.-W., P. Keller, N. &amp; Yin, W.-B. Harnessing diverse transcriptional regulators for natural product discovery in fungi. Nat. Prod. Rep. 37, 6\u201316 (2020).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1039\/C8NP00027A\" data-track-item_id=\"10.1039\/C8NP00027A\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1039%2FC8NP00027A\" aria-label=\"Article reference 56\" data-doi=\"10.1039\/C8NP00027A\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC1MXosVSrtL0%3D\" aria-label=\"CAS reference 56\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=31033969\" aria-label=\"PubMed reference 56\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 56\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Harnessing%20diverse%20transcriptional%20regulators%20for%20natural%20product%20discovery%20in%20fungi&amp;journal=Nat.%20Prod.%20Rep.&amp;doi=10.1039%2FC8NP00027A&amp;volume=37&amp;pages=6-16&amp;publication_year=2020&amp;author=Lyu%2CH-N&amp;author=Liu%2CH-W&amp;author=P.%20Keller%2CN&amp;author=Yin%2CW-B\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR57\">Anderssen, S. et al. AURTHO: Autoregulation of transcription factors as facilitator of cis-acting element discovery. Biochim. Biophys. Acta BBA &#8211; Gene Regul. Mech. 1865, 194847 (2022).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1016\/j.bbagrm.2022.194847\" data-track-item_id=\"10.1016\/j.bbagrm.2022.194847\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1016%2Fj.bbagrm.2022.194847\" aria-label=\"Article reference 57\" data-doi=\"10.1016\/j.bbagrm.2022.194847\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB38XitVGntL7L\" aria-label=\"CAS reference 57\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 57\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=AURTHO%3A%20Autoregulation%20of%20transcription%20factors%20as%20facilitator%20of%20cis-acting%20element%20discovery&amp;journal=Biochim.%20Biophys.%20Acta%20BBA%20-%20Gene%20Regul.%20Mech.&amp;doi=10.1016%2Fj.bbagrm.2022.194847&amp;volume=1865&amp;publication_year=2022&amp;author=Anderssen%2CS\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR58\">Mart\u00edn, J.-F. &amp; Liras, P. Engineering of regulatory cascades and networks controlling antibiotic biosynthesis in Streptomyces. Curr. Opin. Microbiol. 13, 263\u2013273 (2010).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1016\/j.mib.2010.02.008\" data-track-item_id=\"10.1016\/j.mib.2010.02.008\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1016%2Fj.mib.2010.02.008\" aria-label=\"Article reference 58\" data-doi=\"10.1016\/j.mib.2010.02.008\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=20303823\" aria-label=\"PubMed reference 58\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 58\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Engineering%20of%20regulatory%20cascades%20and%20networks%20controlling%20antibiotic%20biosynthesis%20in%20Streptomyces&amp;journal=Curr.%20Opin.%20Microbiol.&amp;doi=10.1016%2Fj.mib.2010.02.008&amp;volume=13&amp;pages=263-273&amp;publication_year=2010&amp;author=Mart%C3%ADn%2CJ-F&amp;author=Liras%2CP\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR59\">Romero-Rodr\u00edguez, A. et al. Interplay between carbon, nitrogen and phosphate utilization in the control of secondary metabolite production in Streptomyces. Antonie Van. Leeuwenhoek 111, 761\u2013781 (2018).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"noopener nofollow\" data-track-label=\"10.1007\/s10482-018-1073-1\" data-track-item_id=\"10.1007\/s10482-018-1073-1\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/link.springer.com\/doi\/10.1007\/s10482-018-1073-1\" aria-label=\"Article reference 59\" data-doi=\"10.1007\/s10482-018-1073-1\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=29605896\" aria-label=\"PubMed reference 59\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 59\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Interplay%20between%20carbon%2C%20nitrogen%20and%20phosphate%20utilization%20in%20the%20control%20of%20secondary%20metabolite%20production%20in%20Streptomyces&amp;journal=Antonie%20Van.%20Leeuwenhoek&amp;doi=10.1007%2Fs10482-018-1073-1&amp;volume=111&amp;pages=761-781&amp;publication_year=2018&amp;author=Romero-Rodr%C3%ADguez%2CA\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR60\">Lu, W., Alanzi, A. R., Abugrain, M. E., Ito, T. &amp; Mahmud, T. Global and pathway-specific transcriptional regulations of pactamycin biosynthesis in Streptomyces pactum. Appl. Microbiol. Biotechnol. 102, 10589\u201310601 (2018).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"noopener nofollow\" data-track-label=\"10.1007\/s00253-018-9375-9\" data-track-item_id=\"10.1007\/s00253-018-9375-9\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/link.springer.com\/doi\/10.1007\/s00253-018-9375-9\" aria-label=\"Article reference 60\" data-doi=\"10.1007\/s00253-018-9375-9\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC1cXhvVeqs7vL\" aria-label=\"CAS reference 60\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=30276712\" aria-label=\"PubMed reference 60\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6258269\" aria-label=\"PubMed Central reference 60\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 60\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Global%20and%20pathway-specific%20transcriptional%20regulations%20of%20pactamycin%20biosynthesis%20in%20Streptomyces%20pactum&amp;journal=Appl.%20Microbiol.%20Biotechnol.&amp;doi=10.1007%2Fs00253-018-9375-9&amp;volume=102&amp;pages=10589-10601&amp;publication_year=2018&amp;author=Lu%2CW&amp;author=Alanzi%2CAR&amp;author=Abugrain%2CME&amp;author=Ito%2CT&amp;author=Mahmud%2CT\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR61\">Mart\u00edn, J. F. et al. Cross-talk of global nutritional regulators in the control of primary and secondary metabolism in Streptomyces. Microb. Biotechnol. 4, 165\u2013174 (2011).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1111\/j.1751-7915.2010.00235.x\" data-track-item_id=\"10.1111\/j.1751-7915.2010.00235.x\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1111%2Fj.1751-7915.2010.00235.x\" aria-label=\"Article reference 61\" data-doi=\"10.1111\/j.1751-7915.2010.00235.x\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=21342462\" aria-label=\"PubMed reference 61\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 61\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Cross-talk%20of%20global%20nutritional%20regulators%20in%20the%20control%20of%20primary%20and%20secondary%20metabolism%20in%20Streptomyces&amp;journal=Microb.%20Biotechnol.&amp;doi=10.1111%2Fj.1751-7915.2010.00235.x&amp;volume=4&amp;pages=165-174&amp;publication_year=2011&amp;author=Mart%C3%ADn%2CJF\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR62\">Apel, A. K., Sola-Landa, A., Rodr\u00edguez-Garc\u00eda, A. &amp; Mart\u00edn, J. F. Phosphate control of phoA, phoC and phoD gene expression in Streptomyces coelicolor reveals significant differences in binding of PhoP to their promoter regions. Microbiology 153, 3527\u20133537 (2007).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1099\/mic.0.2007\/007070-0\" data-track-item_id=\"10.1099\/mic.0.2007\/007070-0\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1099%2Fmic.0.2007%2F007070-0\" aria-label=\"Article reference 62\" data-doi=\"10.1099\/mic.0.2007\/007070-0\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DC%2BD2sXht1SmurjL\" aria-label=\"CAS reference 62\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=17906150\" aria-label=\"PubMed reference 62\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 62\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Phosphate%20control%20of%20phoA%2C%20phoC%20and%20phoD%20gene%20expression%20in%20Streptomyces%20coelicolor%20reveals%20significant%20differences%20in%20binding%20of%20PhoP%20to%20their%20promoter%20regions&amp;journal=Microbiology&amp;doi=10.1099%2Fmic.0.2007%2F007070-0&amp;volume=153&amp;pages=3527-3537&amp;publication_year=2007&amp;author=Apel%2CAK&amp;author=Sola-Landa%2CA&amp;author=Rodr%C3%ADguez-Garc%C3%ADa%2CA&amp;author=Mart%C3%ADn%2CJF\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR63\">Atsushi, M., Soon-Kwang, H., Hiroshi, I., Sueharu, H. &amp; Teruhiko, B. Phosphorylation of the AfsR protein involved in secondary metabolism in Streptomyces species by a eukaryotic-type protein kinase. Gene 146, 47\u201356 (1994).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1016\/0378-1119(94)90832-X\" data-track-item_id=\"10.1016\/0378-1119(94)90832-X\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1016%2F0378-1119%2894%2990832-X\" aria-label=\"Article reference 63\" data-doi=\"10.1016\/0378-1119(94)90832-X\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 63\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Phosphorylation%20of%20the%20AfsR%20protein%20involved%20in%20secondary%20metabolism%20in%20Streptomyces%20species%20by%20a%20eukaryotic-type%20protein%20kinase&amp;journal=Gene&amp;doi=10.1016%2F0378-1119%2894%2990832-X&amp;volume=146&amp;pages=47-56&amp;publication_year=1994&amp;author=Atsushi%2CM&amp;author=Soon-Kwang%2CH&amp;author=Hiroshi%2CI&amp;author=Sueharu%2CH&amp;author=Teruhiko%2CB\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR64\">Santos-Beneit, F., Rodr\u00edguez-Garc\u00eda, A. &amp; Mart\u00edn, J. F. Complex transcriptional control of the antibiotic regulator afsS in Streptomyces: PhoP and AfsR are overlapping, competitive activators\u25bf. J. Bacteriol. 193, 2242\u20132251 (2011).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1128\/JB.01462-10\" data-track-item_id=\"10.1128\/JB.01462-10\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1128%2FJB.01462-10\" aria-label=\"Article reference 64\" data-doi=\"10.1128\/JB.01462-10\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC3MXotFSjuro%3D\" aria-label=\"CAS reference 64\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=21378195\" aria-label=\"PubMed reference 64\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3133061\" aria-label=\"PubMed Central reference 64\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 64\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Complex%20transcriptional%20control%20of%20the%20antibiotic%20regulator%20afsS%20in%20Streptomyces%3A%20PhoP%20and%20AfsR%20are%20overlapping%2C%20competitive%20activators%E2%96%BF&amp;journal=J.%20Bacteriol.&amp;doi=10.1128%2FJB.01462-10&amp;volume=193&amp;pages=2242-2251&amp;publication_year=2011&amp;author=Santos-Beneit%2CF&amp;author=Rodr%C3%ADguez-Garc%C3%ADa%2CA&amp;author=Mart%C3%ADn%2CJF\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR65\">He, J.-M. et al. Direct involvement of the master nitrogen metabolism regulator glnr in antibiotic biosynthesis in Streptomyces*. J. Biol. Chem. 291, 26443\u201326454 (2016).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1074\/jbc.M116.762476\" data-track-item_id=\"10.1074\/jbc.M116.762476\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1074%2Fjbc.M116.762476\" aria-label=\"Article reference 65\" data-doi=\"10.1074\/jbc.M116.762476\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC28XitV2rsL%2FF\" aria-label=\"CAS reference 65\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=27875313\" aria-label=\"PubMed reference 65\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5159505\" aria-label=\"PubMed Central reference 65\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 65\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Direct%20involvement%20of%20the%20master%20nitrogen%20metabolism%20regulator%20glnr%20in%20antibiotic%20biosynthesis%20in%20Streptomyces%2A&amp;journal=J.%20Biol.%20Chem.&amp;doi=10.1074%2Fjbc.M116.762476&amp;volume=291&amp;pages=26443-26454&amp;publication_year=2016&amp;author=He%2CJ-M\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR66\">Shu, D. et al. afsQ1-Q2-sigQ is a pleiotropic but conditionally required signal transduction system for both secondary metabolism and morphological development in Streptomyces coelicolor. Appl. Microbiol. Biotechnol. 81, 1149\u20131160 (2009).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"noopener nofollow\" data-track-label=\"10.1007\/s00253-008-1738-1\" data-track-item_id=\"10.1007\/s00253-008-1738-1\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/link.springer.com\/doi\/10.1007\/s00253-008-1738-1\" aria-label=\"Article reference 66\" data-doi=\"10.1007\/s00253-008-1738-1\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DC%2BD1cXhsFarsrvN\" aria-label=\"CAS reference 66\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=18949475\" aria-label=\"PubMed reference 66\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 66\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=afsQ1-Q2-sigQ%20is%20a%20pleiotropic%20but%20conditionally%20required%20signal%20transduction%20system%20for%20both%20secondary%20metabolism%20and%20morphological%20development%20in%20Streptomyces%20coelicolor&amp;journal=Appl.%20Microbiol.%20Biotechnol.&amp;doi=10.1007%2Fs00253-008-1738-1&amp;volume=81&amp;pages=1149-1160&amp;publication_year=2009&amp;author=Shu%2CD\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR67\">Mart\u00edn, J. F. &amp; Liras, P. The balance metabolism safety net: integration of stress signals by interacting transcriptional factors in Streptomyces and related actinobacteria. Front. Microbiol. 10, 3120 (2020).<\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR68\">Pullan, S. T., Chandra, G., Bibb, M. J. &amp; Merrick, M. Genome-wide analysis of the role of GlnR in Streptomyces venezuelae provides new insights into global nitrogen regulation in actinomycetes. BMC Genomics 12, 175 (2011).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"noopener nofollow\" data-track-label=\"10.1186\/1471-2164-12-175\" data-track-item_id=\"10.1186\/1471-2164-12-175\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/link.springer.com\/doi\/10.1186\/1471-2164-12-175\" aria-label=\"Article reference 68\" data-doi=\"10.1186\/1471-2164-12-175\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC3MXkvV2guro%3D\" aria-label=\"CAS reference 68\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=21463507\" aria-label=\"PubMed reference 68\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3087709\" aria-label=\"PubMed Central reference 68\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 68\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Genome-wide%20analysis%20of%20the%20role%20of%20GlnR%20in%20Streptomyces%20venezuelae%20provides%20new%20insights%20into%20global%20nitrogen%20regulation%20in%20actinomycetes&amp;journal=BMC%20Genomics&amp;doi=10.1186%2F1471-2164-12-175&amp;volume=12&amp;publication_year=2011&amp;author=Pullan%2CST&amp;author=Chandra%2CG&amp;author=Bibb%2CMJ&amp;author=Merrick%2CM\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR69\">Romero-Rodr\u00edguez, A., Ruiz-Villaf\u00e1n, B., Tierrafr\u00eda, V. H., Rodr\u00edguez-Sanoja, R. &amp; S\u00e1nchez, S. Carbon catabolite regulation of secondary metabolite formation and morphological differentiation in Streptomyces coelicolor. Appl. Biochem. Biotechnol. 180, 1152\u20131166 (2016).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"noopener nofollow\" data-track-label=\"10.1007\/s12010-016-2158-9\" data-track-item_id=\"10.1007\/s12010-016-2158-9\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/link.springer.com\/doi\/10.1007\/s12010-016-2158-9\" aria-label=\"Article reference 69\" data-doi=\"10.1007\/s12010-016-2158-9\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=27372741\" aria-label=\"PubMed reference 69\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 69\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Carbon%20catabolite%20regulation%20of%20secondary%20metabolite%20formation%20and%20morphological%20differentiation%20in%20Streptomyces%20coelicolor&amp;journal=Appl.%20Biochem.%20Biotechnol.&amp;doi=10.1007%2Fs12010-016-2158-9&amp;volume=180&amp;pages=1152-1166&amp;publication_year=2016&amp;author=Romero-Rodr%C3%ADguez%2CA&amp;author=Ruiz-Villaf%C3%A1n%2CB&amp;author=Tierrafr%C3%ADa%2CVH&amp;author=Rodr%C3%ADguez-Sanoja%2CR&amp;author=S%C3%A1nchez%2CS\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR70\">Rigali, S. et al. Feast or famine: the global regulator DasR links nutrient stress to antibiotic production by Streptomyces. EMBO Rep. 9, 670\u2013675 (2008).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1038\/embor.2008.83\" data-track-item_id=\"10.1038\/embor.2008.83\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1038%2Fembor.2008.83\" aria-label=\"Article reference 70\" data-doi=\"10.1038\/embor.2008.83\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DC%2BD1cXnvV2rs7Y%3D\" aria-label=\"CAS reference 70\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=18511939\" aria-label=\"PubMed reference 70\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2475330\" aria-label=\"PubMed Central reference 70\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 70\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Feast%20or%20famine%3A%20the%20global%20regulator%20DasR%20links%20nutrient%20stress%20to%20antibiotic%20production%20by%20Streptomyces&amp;journal=EMBO%20Rep.&amp;doi=10.1038%2Fembor.2008.83&amp;volume=9&amp;pages=670-675&amp;publication_year=2008&amp;author=Rigali%2CS\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR71\">Rodr\u00edguez-Garc\u00eda, A., Sola-Landa, A., Apel, K., Santos-Beneit, F. &amp; Mart\u00edn, J. F. Phosphate control over nitrogen metabolism in Streptomyces coelicolor: direct and indirect negative control of glnR, glnA, glnII and amtB expression by the response regulator PhoP. Nucleic Acids Res. 37, 3230\u20133242 (2009).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1093\/nar\/gkp162\" data-track-item_id=\"10.1093\/nar\/gkp162\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1093%2Fnar%2Fgkp162\" aria-label=\"Article reference 71\" data-doi=\"10.1093\/nar\/gkp162\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=19321498\" aria-label=\"PubMed reference 71\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2691820\" aria-label=\"PubMed Central reference 71\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 71\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Phosphate%20control%20over%20nitrogen%20metabolism%20in%20Streptomyces%20coelicolor%3A%20direct%20and%20indirect%20negative%20control%20of%20glnR%2C%20glnA%2C%20glnII%20and%20amtB%20expression%20by%20the%20response%20regulator%20PhoP&amp;journal=Nucleic%20Acids%20Res.&amp;doi=10.1093%2Fnar%2Fgkp162&amp;volume=37&amp;pages=3230-3242&amp;publication_year=2009&amp;author=Rodr%C3%ADguez-Garc%C3%ADa%2CA&amp;author=Sola-Landa%2CA&amp;author=Apel%2CK&amp;author=Santos-Beneit%2CF&amp;author=Mart%C3%ADn%2CJF\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR72\">D\u00edaz, M., Esteban, A., Fern\u00e1ndez-Abalos, J. M. &amp; Santamar\u00eda, R. I. The high-affinity phosphate-binding protein PstS is accumulated under high fructose concentrations and mutation of the corresponding gene affects differentiation in Streptomyces lividans. Microbiology 151, 2583\u20132592 (2005).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1099\/mic.0.27983-0\" data-track-item_id=\"10.1099\/mic.0.27983-0\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1099%2Fmic.0.27983-0\" aria-label=\"Article reference 72\" data-doi=\"10.1099\/mic.0.27983-0\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=16079337\" aria-label=\"PubMed reference 72\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 72\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=The%20high-affinity%20phosphate-binding%20protein%20PstS%20is%20accumulated%20under%20high%20fructose%20concentrations%20and%20mutation%20of%20the%20corresponding%20gene%20affects%20differentiation%20in%20Streptomyces%20lividans&amp;journal=Microbiology&amp;doi=10.1099%2Fmic.0.27983-0&amp;volume=151&amp;pages=2583-2592&amp;publication_year=2005&amp;author=D%C3%ADaz%2CM&amp;author=Esteban%2CA&amp;author=Fern%C3%A1ndez-Abalos%2CJM&amp;author=Santamar%C3%ADa%2CRI\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR73\">Cuervo, L., Malmierca, M. G. &amp; Olano, C. An overview of Lsr2 repressor effect in streptomyces spp. secondary metabolism. Microorganisms 12, 2317 (2024).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.3390\/microorganisms12112317\" data-track-item_id=\"10.3390\/microorganisms12112317\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.3390%2Fmicroorganisms12112317\" aria-label=\"Article reference 73\" data-doi=\"10.3390\/microorganisms12112317\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB2MXktFygtbo%3D\" aria-label=\"CAS reference 73\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=39597706\" aria-label=\"PubMed reference 73\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC11596768\" aria-label=\"PubMed Central reference 73\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 73\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=An%20overview%20of%20Lsr2%20repressor%20effect%20in%20streptomyces%20spp.%20secondary%20metabolism&amp;journal=Microorganisms&amp;doi=10.3390%2Fmicroorganisms12112317&amp;volume=12&amp;publication_year=2024&amp;author=Cuervo%2CL&amp;author=Malmierca%2CMG&amp;author=Olano%2CC\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR74\">Marui, J. et al. Kojic acid biosynthesis in Aspergillus oryzae is regulated by a Zn(II)2Cys6 transcriptional activator and induced by kojic acid at the transcriptional level. J. Biosci. Bioeng. 112, 40\u201343 (2011).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1016\/j.jbiosc.2011.03.010\" data-track-item_id=\"10.1016\/j.jbiosc.2011.03.010\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1016%2Fj.jbiosc.2011.03.010\" aria-label=\"Article reference 74\" data-doi=\"10.1016\/j.jbiosc.2011.03.010\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC3MXht1Cgt7jE\" aria-label=\"CAS reference 74\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=21514215\" aria-label=\"PubMed reference 74\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 74\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Kojic%20acid%20biosynthesis%20in%20Aspergillus%20oryzae%20is%20regulated%20by%20a%20Zn%28II%292Cys6%20transcriptional%20activator%20and%20induced%20by%20kojic%20acid%20at%20the%20transcriptional%20level&amp;journal=J.%20Biosci.%20Bioeng.&amp;doi=10.1016%2Fj.jbiosc.2011.03.010&amp;volume=112&amp;pages=40-43&amp;publication_year=2011&amp;author=Marui%2CJ\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR75\">Bok, J. W. et al. GliZ, a transcriptional regulator of gliotoxin biosynthesis, contributes to Aspergillus fumigatus Virulence. Infect. Immun. 74, 6761\u20136768 (2006).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1128\/IAI.00780-06\" data-track-item_id=\"10.1128\/IAI.00780-06\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1128%2FIAI.00780-06\" aria-label=\"Article reference 75\" data-doi=\"10.1128\/IAI.00780-06\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DC%2BD28XhtlWgs7jE\" aria-label=\"CAS reference 75\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=17030582\" aria-label=\"PubMed reference 75\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC1698057\" aria-label=\"PubMed Central reference 75\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 75\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=GliZ%2C%20a%20transcriptional%20regulator%20of%20gliotoxin%20biosynthesis%2C%20contributes%20to%20Aspergillus%20fumigatus%20Virulence&amp;journal=Infect.%20Immun.&amp;doi=10.1128%2FIAI.00780-06&amp;volume=74&amp;pages=6761-6768&amp;publication_year=2006&amp;author=Bok%2CJW\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR76\">Gramajo, H. C., Takano, E. &amp; Bibb, M. J. Stationary-phase production of the antibiotic actinorhodin in Streptomyces coelicolor A3(2) is transcriptionally regulated. Mol. Microbiol. 7, 837\u2013845 (1993).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1111\/j.1365-2958.1993.tb01174.x\" data-track-item_id=\"10.1111\/j.1365-2958.1993.tb01174.x\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1111%2Fj.1365-2958.1993.tb01174.x\" aria-label=\"Article reference 76\" data-doi=\"10.1111\/j.1365-2958.1993.tb01174.x\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DyaK3sXit1Onsb8%3D\" aria-label=\"CAS reference 76\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=7683365\" aria-label=\"PubMed reference 76\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 76\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Stationary-phase%20production%20of%20the%20antibiotic%20actinorhodin%20in%20Streptomyces%20coelicolor%20A3%282%29%20is%20transcriptionally%20regulated&amp;journal=Mol.%20Microbiol.&amp;doi=10.1111%2Fj.1365-2958.1993.tb01174.x&amp;volume=7&amp;pages=837-845&amp;publication_year=1993&amp;author=Gramajo%2CHC&amp;author=Takano%2CE&amp;author=Bibb%2CMJ\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR77\">Augustijn, H. E. et al. Genome mining based on transcriptional regulatory networks uncovers a novel locus involved in desferrioxamine biosynthesis. PLOS Biol. 23, e3003183 (2025).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1371\/journal.pbio.3003183\" data-track-item_id=\"10.1371\/journal.pbio.3003183\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1371%2Fjournal.pbio.3003183\" aria-label=\"Article reference 77\" data-doi=\"10.1371\/journal.pbio.3003183\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB2MXhtlyrtL%2FO\" aria-label=\"CAS reference 77\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=40504771\" aria-label=\"PubMed reference 77\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC12161575\" aria-label=\"PubMed Central reference 77\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 77\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Genome%20mining%20based%20on%20transcriptional%20regulatory%20networks%20uncovers%20a%20novel%20locus%20involved%20in%20desferrioxamine%20biosynthesis&amp;journal=PLOS%20Biol.&amp;doi=10.1371%2Fjournal.pbio.3003183&amp;volume=23&amp;publication_year=2025&amp;author=Augustijn%2CHE\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR78\">Dorman, C. J. Function of Nucleoid-Associated Proteins in Chromosome Structuring and Transcriptional Regulation. J. Mol. Microbiol. Biotechnol. 24, 316\u2013331 (2015).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 78\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Function%20of%20Nucleoid-Associated%20Proteins%20in%20Chromosome%20Structuring%20and%20Transcriptional%20Regulation&amp;journal=J.%20Mol.%20Microbiol.%20Biotechnol.&amp;volume=24&amp;pages=316-331&amp;publication_year=2015&amp;author=Dorman%2CCJ\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR79\">Dillon, S. C. &amp; Dorman, C. J. Bacterial nucleoid-associated proteins, nucleoid structure and gene expression. Nat. Rev. Microbiol. 8, 185\u2013195 (2010).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1038\/nrmicro2261\" data-track-item_id=\"10.1038\/nrmicro2261\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1038%2Fnrmicro2261\" aria-label=\"Article reference 79\" data-doi=\"10.1038\/nrmicro2261\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC3cXhs1Omtbc%3D\" aria-label=\"CAS reference 79\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=20140026\" aria-label=\"PubMed reference 79\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 79\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Bacterial%20nucleoid-associated%20proteins%2C%20nucleoid%20structure%20and%20gene%20expression&amp;journal=Nat.%20Rev.%20Microbiol.&amp;doi=10.1038%2Fnrmicro2261&amp;volume=8&amp;pages=185-195&amp;publication_year=2010&amp;author=Dillon%2CSC&amp;author=Dorman%2CCJ\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR80\">Gehrke, E. J. et al. Silencing cryptic specialized metabolism in Streptomyces by the nucleoid-associated protein Lsr2. eLife 8, e47691 (2019).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.7554\/eLife.47691\" data-track-item_id=\"10.7554\/eLife.47691\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.7554%2FeLife.47691\" aria-label=\"Article reference 80\" data-doi=\"10.7554\/eLife.47691\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB3cXhtlals77M\" aria-label=\"CAS reference 80\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=31215866\" aria-label=\"PubMed reference 80\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6584129\" aria-label=\"PubMed Central reference 80\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 80\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Silencing%20cryptic%20specialized%20metabolism%20in%20Streptomyces%20by%20the%20nucleoid-associated%20protein%20Lsr2&amp;journal=eLife&amp;doi=10.7554%2FeLife.47691&amp;volume=8&amp;publication_year=2019&amp;author=Gehrke%2CEJ\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR81\">Palmer, J. M. &amp; Keller, N. P. Secondary metabolism in fungi: does chromosomal location matter? Curr. Opin. Microbiol. 13, 431\u2013436 (2010).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1016\/j.mib.2010.04.008\" data-track-item_id=\"10.1016\/j.mib.2010.04.008\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1016%2Fj.mib.2010.04.008\" aria-label=\"Article reference 81\" data-doi=\"10.1016\/j.mib.2010.04.008\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC3cXpvVaqtLo%3D\" aria-label=\"CAS reference 81\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=20627806\" aria-label=\"PubMed reference 81\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2922032\" aria-label=\"PubMed Central reference 81\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 81\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Secondary%20metabolism%20in%20fungi%3A%20does%20chromosomal%20location%20matter%3F&amp;journal=Curr.%20Opin.%20Microbiol.&amp;doi=10.1016%2Fj.mib.2010.04.008&amp;volume=13&amp;pages=431-436&amp;publication_year=2010&amp;author=Palmer%2CJM&amp;author=Keller%2CNP\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR82\">Collemare, J. &amp; Seidl, M. F. Chromatin-dependent regulation of secondary metabolite biosynthesis in fungi: is the picture complete? FEMS Microbiol. Rev. 43, 591\u2013607 (2019).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1093\/femsre\/fuz018\" data-track-item_id=\"10.1093\/femsre\/fuz018\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1093%2Ffemsre%2Ffuz018\" aria-label=\"Article reference 82\" data-doi=\"10.1093\/femsre\/fuz018\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB3cXhtFalurfN\" aria-label=\"CAS reference 82\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=31301226\" aria-label=\"PubMed reference 82\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8038932\" aria-label=\"PubMed Central reference 82\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 82\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Chromatin-dependent%20regulation%20of%20secondary%20metabolite%20biosynthesis%20in%20fungi%3A%20is%20the%20picture%20complete%3F&amp;journal=FEMS%20Microbiol.%20Rev.&amp;doi=10.1093%2Ffemsre%2Ffuz018&amp;volume=43&amp;pages=591-607&amp;publication_year=2019&amp;author=Collemare%2CJ&amp;author=Seidl%2CMF\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR83\">Strauss, J. &amp; Reyes-Dominguez, Y. Regulation of secondary metabolism by chromatin structure and epigenetic codes. Fungal Genet. Biol. 48, 62\u201369 (2011).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1016\/j.fgb.2010.07.009\" data-track-item_id=\"10.1016\/j.fgb.2010.07.009\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1016%2Fj.fgb.2010.07.009\" aria-label=\"Article reference 83\" data-doi=\"10.1016\/j.fgb.2010.07.009\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC3cXhsVGnur%2FO\" aria-label=\"CAS reference 83\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=20659575\" aria-label=\"PubMed reference 83\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 83\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Regulation%20of%20secondary%20metabolism%20by%20chromatin%20structure%20and%20epigenetic%20codes&amp;journal=Fungal%20Genet.%20Biol.&amp;doi=10.1016%2Fj.fgb.2010.07.009&amp;volume=48&amp;pages=62-69&amp;publication_year=2011&amp;author=Strauss%2CJ&amp;author=Reyes-Dominguez%2CY\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR84\">Connolly, L. R., Smith, K. M. &amp; Freitag, M. The Fusarium graminearum Histone H3 K27 Methyltransferase KMT6 Regulates Development and Expression of Secondary Metabolite Gene Clusters. PLOS Genet. 9, e1003916 (2013).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1371\/journal.pgen.1003916\" data-track-item_id=\"10.1371\/journal.pgen.1003916\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1371%2Fjournal.pgen.1003916\" aria-label=\"Article reference 84\" data-doi=\"10.1371\/journal.pgen.1003916\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=24204317\" aria-label=\"PubMed reference 84\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3814326\" aria-label=\"PubMed Central reference 84\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 84\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=The%20Fusarium%20graminearum%20Histone%20H3%20K27%20Methyltransferase%20KMT6%20Regulates%20Development%20and%20Expression%20of%20Secondary%20Metabolite%20Gene%20Clusters&amp;journal=PLOS%20Genet.&amp;doi=10.1371%2Fjournal.pgen.1003916&amp;volume=9&amp;publication_year=2013&amp;author=Connolly%2CLR&amp;author=Smith%2CKM&amp;author=Freitag%2CM\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR85\">Gacek, A. &amp; Strauss, J. The chromatin code of fungal secondary metabolite gene clusters. Appl. Microbiol. Biotechnol. 95, 1389\u20131404 (2012).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"noopener nofollow\" data-track-label=\"10.1007\/s00253-012-4208-8\" data-track-item_id=\"10.1007\/s00253-012-4208-8\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/link.springer.com\/doi\/10.1007\/s00253-012-4208-8\" aria-label=\"Article reference 85\" data-doi=\"10.1007\/s00253-012-4208-8\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC38Xht1Ggs7zN\" aria-label=\"CAS reference 85\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=22814413\" aria-label=\"PubMed reference 85\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3427479\" aria-label=\"PubMed Central reference 85\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 85\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=The%20chromatin%20code%20of%20fungal%20secondary%20metabolite%20gene%20clusters&amp;journal=Appl.%20Microbiol.%20Biotechnol.&amp;doi=10.1007%2Fs00253-012-4208-8&amp;volume=95&amp;pages=1389-1404&amp;publication_year=2012&amp;author=Gacek%2CA&amp;author=Strauss%2CJ\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR86\">Jamieson, K., Rountree, M. R., Lewis, Z. A., Stajich, J. E. &amp; Selker, E. U. Regional control of histone H3 lysine 27 methylation in Neurospora. Proc. Natl. Acad. Sci. 110, 6027\u20136032 (2013).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1073\/pnas.1303750110\" data-track-item_id=\"10.1073\/pnas.1303750110\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1073%2Fpnas.1303750110\" aria-label=\"Article reference 86\" data-doi=\"10.1073\/pnas.1303750110\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC3sXnsFKktr4%3D\" aria-label=\"CAS reference 86\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=23530226\" aria-label=\"PubMed reference 86\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3625340\" aria-label=\"PubMed Central reference 86\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 86\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Regional%20control%20of%20histone%20H3%20lysine%2027%20methylation%20in%20Neurospora&amp;journal=Proc.%20Natl.%20Acad.%20Sci.&amp;doi=10.1073%2Fpnas.1303750110&amp;volume=110&amp;pages=6027-6032&amp;publication_year=2013&amp;author=Jamieson%2CK&amp;author=Rountree%2CMR&amp;author=Lewis%2CZA&amp;author=Stajich%2CJE&amp;author=Selker%2CEU\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR87\">Wiemann, P. et al. Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites. PLOS Pathog. 9, e1003475 (2013).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1371\/journal.ppat.1003475\" data-track-item_id=\"10.1371\/journal.ppat.1003475\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1371%2Fjournal.ppat.1003475\" aria-label=\"Article reference 87\" data-doi=\"10.1371\/journal.ppat.1003475\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC3sXhtFCntrbF\" aria-label=\"CAS reference 87\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=23825955\" aria-label=\"PubMed reference 87\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3694855\" aria-label=\"PubMed Central reference 87\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 87\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Deciphering%20the%20cryptic%20genome%3A%20genome-wide%20analyses%20of%20the%20rice%20pathogen%20Fusarium%20fujikuroi%20reveal%20complex%20regulation%20of%20secondary%20metabolism%20and%20novel%20metabolites&amp;journal=PLOS%20Pathog.&amp;doi=10.1371%2Fjournal.ppat.1003475&amp;volume=9&amp;publication_year=2013&amp;author=Wiemann%2CP\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR88\">Bok, J. W. &amp; Keller, N. P. LaeA, a regulator of secondary metabolism in Aspergillus spp. Eukaryot. Cell 3, 527\u2013535 (2004).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1128\/EC.3.2.527-535.2004\" data-track-item_id=\"10.1128\/EC.3.2.527-535.2004\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1128%2FEC.3.2.527-535.2004\" aria-label=\"Article reference 88\" data-doi=\"10.1128\/EC.3.2.527-535.2004\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DC%2BD2cXjtlKqs7s%3D\" aria-label=\"CAS reference 88\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=15075281\" aria-label=\"PubMed reference 88\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC387652\" aria-label=\"PubMed Central reference 88\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 88\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=LaeA%2C%20a%20regulator%20of%20secondary%20metabolism%20in%20Aspergillus%20spp&amp;journal=Eukaryot.%20Cell&amp;doi=10.1128%2FEC.3.2.527-535.2004&amp;volume=3&amp;pages=527-535&amp;publication_year=2004&amp;author=Bok%2CJW&amp;author=Keller%2CNP\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR89\">Van Assche, E., Van Puyvelde, S., Vanderleyden, J. &amp; Steenackers, H. P. RNA-binding proteins involved in post-transcriptional regulation in bacteria. Front. Microbiol. 6, 141 (2015).<\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR90\">Romeo, T., Vakulskas, C. A. &amp; Babitzke, P. Post-transcriptional regulation on a global scale: form and function of Csr\/Rsm systems. Environ. Microbiol. 15, 313\u2013324 (2013).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1111\/j.1462-2920.2012.02794.x\" data-track-item_id=\"10.1111\/j.1462-2920.2012.02794.x\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1111%2Fj.1462-2920.2012.02794.x\" aria-label=\"Article reference 90\" data-doi=\"10.1111\/j.1462-2920.2012.02794.x\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC3sXhvVCisbc%3D\" aria-label=\"CAS reference 90\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=22672726\" aria-label=\"PubMed reference 90\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 90\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Post-transcriptional%20regulation%20on%20a%20global%20scale%3A%20form%20and%20function%20of%20Csr%2FRsm%20systems&amp;journal=Environ.%20Microbiol.&amp;doi=10.1111%2Fj.1462-2920.2012.02794.x&amp;volume=15&amp;pages=313-324&amp;publication_year=2013&amp;author=Romeo%2CT&amp;author=Vakulskas%2CCA&amp;author=Babitzke%2CP\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR91\">Mukherjee, A., Cui, Y., Liu, Y., Dumenyo, C. K. &amp; Chatterjee, A. K. Global regulation in Erwinia species by Erwinia carotovora rsmA, a homologue of Escherichia coli csrA: repression of secondary metabolites, pathogenicity and hypersensitive reaction. Microbiology 142, 427\u2013434 (1996).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1099\/13500872-142-2-427\" data-track-item_id=\"10.1099\/13500872-142-2-427\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1099%2F13500872-142-2-427\" aria-label=\"Article reference 91\" data-doi=\"10.1099\/13500872-142-2-427\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DyaK28XhtlSitrk%3D\" aria-label=\"CAS reference 91\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=8932714\" aria-label=\"PubMed reference 91\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 91\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Global%20regulation%20in%20Erwinia%20species%20by%20Erwinia%20carotovora%20rsmA%2C%20a%20homologue%20of%20Escherichia%20coli%20csrA%3A%20repression%20of%20secondary%20metabolites%2C%20pathogenicity%20and%20hypersensitive%20reaction&amp;journal=Microbiology&amp;doi=10.1099%2F13500872-142-2-427&amp;volume=142&amp;pages=427-434&amp;publication_year=1996&amp;author=Mukherjee%2CA&amp;author=Cui%2CY&amp;author=Liu%2CY&amp;author=Dumenyo%2CCK&amp;author=Chatterjee%2CAK\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR92\">Swiercz, J. P. et al. Small non-coding RNAs in Streptomyces coelicolor. Nucleic Acids Res. 36, 7240\u20137251 (2008).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1093\/nar\/gkn898\" data-track-item_id=\"10.1093\/nar\/gkn898\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1093%2Fnar%2Fgkn898\" aria-label=\"Article reference 92\" data-doi=\"10.1093\/nar\/gkn898\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DC%2BD1cXhsV2rsrnJ\" aria-label=\"CAS reference 92\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=19008244\" aria-label=\"PubMed reference 92\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2602773\" aria-label=\"PubMed Central reference 92\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 92\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Small%20non-coding%20RNAs%20in%20Streptomyces%20coelicolor&amp;journal=Nucleic%20Acids%20Res.&amp;doi=10.1093%2Fnar%2Fgkn898&amp;volume=36&amp;pages=7240-7251&amp;publication_year=2008&amp;author=Swiercz%2CJP\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR93\">Mellin, J. R. &amp; Cossart, P. Unexpected versatility in bacterial riboswitches. Trends Genet. 31, 150\u2013156 (2015).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1016\/j.tig.2015.01.005\" data-track-item_id=\"10.1016\/j.tig.2015.01.005\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1016%2Fj.tig.2015.01.005\" aria-label=\"Article reference 93\" data-doi=\"10.1016\/j.tig.2015.01.005\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC2MXisVOktb8%3D\" aria-label=\"CAS reference 93\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=25708284\" aria-label=\"PubMed reference 93\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 93\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Unexpected%20versatility%20in%20bacterial%20riboswitches&amp;journal=Trends%20Genet.&amp;doi=10.1016%2Fj.tig.2015.01.005&amp;volume=31&amp;pages=150-156&amp;publication_year=2015&amp;author=Mellin%2CJR&amp;author=Cossart%2CP\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR94\">Tucker, B. J. &amp; Breaker, R. R. Riboswitches as versatile gene control elements. Curr. Opin. Struct. Biol. 15, 342\u2013348 (2005).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1016\/j.sbi.2005.05.003\" data-track-item_id=\"10.1016\/j.sbi.2005.05.003\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1016%2Fj.sbi.2005.05.003\" aria-label=\"Article reference 94\" data-doi=\"10.1016\/j.sbi.2005.05.003\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DC%2BD2MXlt1SrsLc%3D\" aria-label=\"CAS reference 94\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=15919195\" aria-label=\"PubMed reference 94\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 94\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Riboswitches%20as%20versatile%20gene%20control%20elements&amp;journal=Curr.%20Opin.%20Struct.%20Biol.&amp;doi=10.1016%2Fj.sbi.2005.05.003&amp;volume=15&amp;pages=342-348&amp;publication_year=2005&amp;author=Tucker%2CBJ&amp;author=Breaker%2CRR\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR95\">Balasubramanian, D. &amp; Vanderpool, C. K. New developments in post-transcriptional regulation of operons by small RNAs. RNA Biol. 10, 337\u2013341 (2013).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.4161\/rna.23696\" data-track-item_id=\"10.4161\/rna.23696\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.4161%2Frna.23696\" aria-label=\"Article reference 95\" data-doi=\"10.4161\/rna.23696\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC2cXjtlag\" aria-label=\"CAS reference 95\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=23392245\" aria-label=\"PubMed reference 95\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3672274\" aria-label=\"PubMed Central reference 95\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 95\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=New%20developments%20in%20post-transcriptional%20regulation%20of%20operons%20by%20small%20RNAs&amp;journal=RNA%20Biol.&amp;doi=10.4161%2Frna.23696&amp;volume=10&amp;pages=337-341&amp;publication_year=2013&amp;author=Balasubramanian%2CD&amp;author=Vanderpool%2CCK\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR96\">Deng, J. et al. A transcription factor-mediated regulatory network controls fungal pathogen colonization of insect body cavities. mBio 15, e03504-23 (2024).<\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR97\">Lozada-Ch\u00e1vez, I., Janga, S. C. &amp; Collado-Vides, J. Bacterial regulatory networks are extremely flexible in evolution. Nucleic Acids Res. 34, 3434\u20133445 (2006).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1093\/nar\/gkl423\" data-track-item_id=\"10.1093\/nar\/gkl423\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1093%2Fnar%2Fgkl423\" aria-label=\"Article reference 97\" data-doi=\"10.1093\/nar\/gkl423\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=16840530\" aria-label=\"PubMed reference 97\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC1524901\" aria-label=\"PubMed Central reference 97\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 97\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Bacterial%20regulatory%20networks%20are%20extremely%20flexible%20in%20evolution&amp;journal=Nucleic%20Acids%20Res.&amp;doi=10.1093%2Fnar%2Fgkl423&amp;volume=34&amp;pages=3434-3445&amp;publication_year=2006&amp;author=Lozada-Ch%C3%A1vez%2CI&amp;author=Janga%2CSC&amp;author=Collado-Vides%2CJ\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR98\">Seshasayee, A. S., Bertone, P., Fraser, G. M. &amp; Luscombe, N. M. Transcriptional regulatory networks in bacteria: from input signals to output responses. Curr. Opin. Microbiol. 9, 511\u2013519 (2006).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1016\/j.mib.2006.08.007\" data-track-item_id=\"10.1016\/j.mib.2006.08.007\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1016%2Fj.mib.2006.08.007\" aria-label=\"Article reference 98\" data-doi=\"10.1016\/j.mib.2006.08.007\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DC%2BD28XpvFSisLo%3D\" aria-label=\"CAS reference 98\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=16942903\" aria-label=\"PubMed reference 98\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 98\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Transcriptional%20regulatory%20networks%20in%20bacteria%3A%20from%20input%20signals%20to%20output%20responses&amp;journal=Curr.%20Opin.%20Microbiol.&amp;doi=10.1016%2Fj.mib.2006.08.007&amp;volume=9&amp;pages=511-519&amp;publication_year=2006&amp;author=Seshasayee%2CAS&amp;author=Bertone%2CP&amp;author=Fraser%2CGM&amp;author=Luscombe%2CNM\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR99\">Augustijn, H. E., Roseboom, A. M., Medema, M. H. &amp; van Wezel, G. P. Harnessing regulatory networks in Actinobacteria for natural product discovery. J. Ind. Microbiol. Biotechnol. 51, kuae011 (2024).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1093\/jimb\/kuae011\" data-track-item_id=\"10.1093\/jimb\/kuae011\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1093%2Fjimb%2Fkuae011\" aria-label=\"Article reference 99\" data-doi=\"10.1093\/jimb\/kuae011\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB2cXovFWjs70%3D\" aria-label=\"CAS reference 99\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=38569653\" aria-label=\"PubMed reference 99\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC10996143\" aria-label=\"PubMed Central reference 99\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 99\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Harnessing%20regulatory%20networks%20in%20Actinobacteria%20for%20natural%20product%20discovery&amp;journal=J.%20Ind.%20Microbiol.%20Biotechnol.&amp;doi=10.1093%2Fjimb%2Fkuae011&amp;volume=51&amp;publication_year=2024&amp;author=Augustijn%2CHE&amp;author=Roseboom%2CAM&amp;author=Medema%2CMH&amp;author=Wezel%2CGP\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR100\">Hwang, S. et al. System-level analysis of transcriptional and translational regulatory elements in Streptomyces griseus. Front. Bioeng. Biotechnol. 10, 844200 (2022).<\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR101\">Hecker, M., Lambeck, S., Toepfer, S., van Someren, E. &amp; Guthke, R. Gene regulatory network inference: Data integration in dynamic models\u2014A review. Biosystems 96, 86\u2013103 (2009).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1016\/j.biosystems.2008.12.004\" data-track-item_id=\"10.1016\/j.biosystems.2008.12.004\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1016%2Fj.biosystems.2008.12.004\" aria-label=\"Article reference 101\" data-doi=\"10.1016\/j.biosystems.2008.12.004\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DC%2BD1MXisl2rsro%3D\" aria-label=\"CAS reference 101\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=19150482\" aria-label=\"PubMed reference 101\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 101\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Gene%20regulatory%20network%20inference%3A%20Data%20integration%20in%20dynamic%20models%E2%80%94A%20review&amp;journal=Biosystems&amp;doi=10.1016%2Fj.biosystems.2008.12.004&amp;volume=96&amp;pages=86-103&amp;publication_year=2009&amp;author=Hecker%2CM&amp;author=Lambeck%2CS&amp;author=Toepfer%2CS&amp;author=Someren%2CE&amp;author=Guthke%2CR\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR102\">Thieffry, D., Huerta, A. M., P\u00e9rez-Rueda, E. &amp; Collado-Vides, J. From specific gene regulation to genomic networks: a global analysis of transcriptional regulation in Escherichia coli. BioEssays 20, 433\u2013440 (1998).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1002\/(SICI)1521-1878(199805)20:5&lt;433::AID-BIES10&gt;3.0.CO;2-2\" data-track-item_id=\"10.1002\/(SICI)1521-1878(199805)20:5&lt;433::AID-BIES10&gt;3.0.CO;2-2\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1002%2F%28SICI%291521-1878%28199805%2920%3A5%3C433%3A%3AAID-BIES10%3E3.0.CO%3B2-2\" aria-label=\"Article reference 102\" data-doi=\"10.1002\/(SICI)1521-1878(199805)20:5&lt;433::AID-BIES10&gt;3.0.CO;2-2\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:STN:280:DyaK1czjsFCksA%3D%3D\" aria-label=\"CAS reference 102\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=9670816\" aria-label=\"PubMed reference 102\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 102\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=From%20specific%20gene%20regulation%20to%20genomic%20networks%3A%20a%20global%20analysis%20of%20transcriptional%20regulation%20in%20Escherichia%20coli&amp;journal=BioEssays&amp;doi=10.1002%2F%28SICI%291521-1878%28199805%2920%3A5%3C433%3A%3AAID-BIES10%3E3.0.CO%3B2-2&amp;volume=20&amp;pages=433-440&amp;publication_year=1998&amp;author=Thieffry%2CD&amp;author=Huerta%2CAM&amp;author=P%C3%A9rez-Rueda%2CE&amp;author=Collado-Vides%2CJ\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR103\">Badia-i-Mompel, P. et al. Gene regulatory network inference in the era of single-cell multi-omics. Nat. Rev. Genet. 24, 739\u2013754 (2023).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1038\/s41576-023-00618-5\" data-track-item_id=\"10.1038\/s41576-023-00618-5\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1038%2Fs41576-023-00618-5\" aria-label=\"Article reference 103\" data-doi=\"10.1038\/s41576-023-00618-5\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB3sXhtlWksrzM\" aria-label=\"CAS reference 103\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=37365273\" aria-label=\"PubMed reference 103\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 103\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Gene%20regulatory%20network%20inference%20in%20the%20era%20of%20single-cell%20multi-omics&amp;journal=Nat.%20Rev.%20Genet.&amp;doi=10.1038%2Fs41576-023-00618-5&amp;volume=24&amp;pages=739-754&amp;publication_year=2023&amp;author=Badia-i-Mompel%2CP\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR104\">Yuan, Q. &amp; Duren, Z. Inferring gene regulatory networks from single-cell multiome data using atlas-scale external data. Nat. Biotechnol. 43, 247\u2013257 (2025).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1038\/s41587-024-02182-7\" data-track-item_id=\"10.1038\/s41587-024-02182-7\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1038%2Fs41587-024-02182-7\" aria-label=\"Article reference 104\" data-doi=\"10.1038\/s41587-024-02182-7\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=38609714\" aria-label=\"PubMed reference 104\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 104\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Inferring%20gene%20regulatory%20networks%20from%20single-cell%20multiome%20data%20using%20atlas-scale%20external%20data&amp;journal=Nat.%20Biotechnol.&amp;doi=10.1038%2Fs41587-024-02182-7&amp;volume=43&amp;pages=247-257&amp;publication_year=2025&amp;author=Yuan%2CQ&amp;author=Duren%2CZ\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR105\">Lyu, M. et al. AccR, a TetR family transcriptional repressor, coordinates short-chain acyl coenzyme A homeostasis in Streptomyces avermitilis. Appl. Environ. Microbiol. 86, e00508\u2013e00520 (2020).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1128\/AEM.00508-20\" data-track-item_id=\"10.1128\/AEM.00508-20\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1128%2FAEM.00508-20\" aria-label=\"Article reference 105\" data-doi=\"10.1128\/AEM.00508-20\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB3cXhsV2iu7fE\" aria-label=\"CAS reference 105\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=32303550\" aria-label=\"PubMed reference 105\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7267193\" aria-label=\"PubMed Central reference 105\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 105\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=AccR%2C%20a%20TetR%20family%20transcriptional%20repressor%2C%20coordinates%20short-chain%20acyl%20coenzyme%20A%20homeostasis%20in%20Streptomyces%20avermitilis&amp;journal=Appl.%20Environ.%20Microbiol.&amp;doi=10.1128%2FAEM.00508-20&amp;volume=86&amp;pages=e00508-e00520&amp;publication_year=2020&amp;author=Lyu%2CM\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR106\">Alam, M. T. et al. Metabolic modeling and analysis of the metabolic switch in Streptomyces coelicolor. BMC Genomics 11, 202 (2010).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"noopener nofollow\" data-track-label=\"10.1186\/1471-2164-11-202\" data-track-item_id=\"10.1186\/1471-2164-11-202\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/link.springer.com\/doi\/10.1186\/1471-2164-11-202\" aria-label=\"Article reference 106\" data-doi=\"10.1186\/1471-2164-11-202\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=20338070\" aria-label=\"PubMed reference 106\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2853524\" aria-label=\"PubMed Central reference 106\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 106\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Metabolic%20modeling%20and%20analysis%20of%20the%20metabolic%20switch%20in%20Streptomyces%20coelicolor&amp;journal=BMC%20Genomics&amp;doi=10.1186%2F1471-2164-11-202&amp;volume=11&amp;publication_year=2010&amp;author=Alam%2CMT\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR107\">Nielsen, J. Cell factory engineering for improved production of natural products. Nat. Prod. Rep. 36, 1233\u20131236 (2019).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1039\/C9NP00005D\" data-track-item_id=\"10.1039\/C9NP00005D\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1039%2FC9NP00005D\" aria-label=\"Article reference 107\" data-doi=\"10.1039\/C9NP00005D\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC1MXnvVKhu74%3D\" aria-label=\"CAS reference 107\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=30997457\" aria-label=\"PubMed reference 107\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 107\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Cell%20factory%20engineering%20for%20improved%20production%20of%20natural%20products&amp;journal=Nat.%20Prod.%20Rep.&amp;doi=10.1039%2FC9NP00005D&amp;volume=36&amp;pages=1233-1236&amp;publication_year=2019&amp;author=Nielsen%2CJ\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR108\">Bode, H. B., Bethe, B., H\u00f6fs, R. &amp; Zeeck, A. Big effects from small changes: possible ways to explore nature\u2019s chemical diversity. ChemBioChem 3, 619\u2013627 (2002).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1002\/1439-7633(20020703)3:7&lt;619::AID-CBIC619&gt;3.0.CO;2-9\" data-track-item_id=\"10.1002\/1439-7633(20020703)3:7&lt;619::AID-CBIC619&gt;3.0.CO;2-9\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1002%2F1439-7633%2820020703%293%3A7%3C619%3A%3AAID-CBIC619%3E3.0.CO%3B2-9\" aria-label=\"Article reference 108\" data-doi=\"10.1002\/1439-7633(20020703)3:7&lt;619::AID-CBIC619&gt;3.0.CO;2-9\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DC%2BD38Xlt1Kmtb0%3D\" aria-label=\"CAS reference 108\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=12324995\" aria-label=\"PubMed reference 108\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 108\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Big%20effects%20from%20small%20changes%3A%20possible%20ways%20to%20explore%20nature%E2%80%99s%20chemical%20diversity&amp;journal=ChemBioChem&amp;doi=10.1002%2F1439-7633%2820020703%293%3A7%3C619%3A%3AAID-CBIC619%3E3.0.CO%3B2-9&amp;volume=3&amp;pages=619-627&amp;publication_year=2002&amp;author=Bode%2CHB&amp;author=Bethe%2CB&amp;author=H%C3%B6fs%2CR&amp;author=Zeeck%2CA\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR109\">Chiang, Y.-M., Chang, S.-L., Oakley, B. R. &amp; Wang, C. C. Recent advances in awakening silent biosynthetic gene clusters and linking orphan clusters to natural products in microorganisms. Curr. Opin. Chem. Biol. 15, 137\u2013143 (2011).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1016\/j.cbpa.2010.10.011\" data-track-item_id=\"10.1016\/j.cbpa.2010.10.011\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1016%2Fj.cbpa.2010.10.011\" aria-label=\"Article reference 109\" data-doi=\"10.1016\/j.cbpa.2010.10.011\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC3MXhvFKitLw%3D\" aria-label=\"CAS reference 109\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=21111669\" aria-label=\"PubMed reference 109\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 109\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Recent%20advances%20in%20awakening%20silent%20biosynthetic%20gene%20clusters%20and%20linking%20orphan%20clusters%20to%20natural%20products%20in%20microorganisms&amp;journal=Curr.%20Opin.%20Chem.%20Biol.&amp;doi=10.1016%2Fj.cbpa.2010.10.011&amp;volume=15&amp;pages=137-143&amp;publication_year=2011&amp;author=Chiang%2CY-M&amp;author=Chang%2CS-L&amp;author=Oakley%2CBR&amp;author=Wang%2CCC\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR110\">Zhang, Y.-Q., Brock, M. &amp; Keller, N. P. Connection of Propionyl-CoA metabolism to polyketide biosynthesis in Aspergillus nidulans. Genetics 168, 785\u2013794 (2004).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1534\/genetics.104.027540\" data-track-item_id=\"10.1534\/genetics.104.027540\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1534%2Fgenetics.104.027540\" aria-label=\"Article reference 110\" data-doi=\"10.1534\/genetics.104.027540\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DC%2BD2cXhtVKms7zN\" aria-label=\"CAS reference 110\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=15514053\" aria-label=\"PubMed reference 110\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC1448837\" aria-label=\"PubMed Central reference 110\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 110\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Connection%20of%20Propionyl-CoA%20metabolism%20to%20polyketide%20biosynthesis%20in%20Aspergillus%20nidulans&amp;journal=Genetics&amp;doi=10.1534%2Fgenetics.104.027540&amp;volume=168&amp;pages=785-794&amp;publication_year=2004&amp;author=Zhang%2CY-Q&amp;author=Brock%2CM&amp;author=Keller%2CNP\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR111\">G\u00f3mez, C. et al. Amino Acid precursor supply in the biosynthesis of the RNA polymerase inhibitor Streptolydigin by Streptomyces lydicus. J. Bacteriol. 193, 4214\u20134223 (2011).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1128\/JB.05062-11\" data-track-item_id=\"10.1128\/JB.05062-11\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1128%2FJB.05062-11\" aria-label=\"Article reference 111\" data-doi=\"10.1128\/JB.05062-11\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=21665968\" aria-label=\"PubMed reference 111\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3147693\" aria-label=\"PubMed Central reference 111\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 111\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Amino%20Acid%20precursor%20supply%20in%20the%20biosynthesis%20of%20the%20RNA%20polymerase%20inhibitor%20Streptolydigin%20by%20Streptomyces%20lydicus&amp;journal=J.%20Bacteriol.&amp;doi=10.1128%2FJB.05062-11&amp;volume=193&amp;pages=4214-4223&amp;publication_year=2011&amp;author=G%C3%B3mez%2CC\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR112\">Choi, J. W. &amp; Da Silva, N. A. Improving polyketide and fatty acid synthesis by engineering of the yeast acetyl-CoA carboxylase. J. Biotechnol. 187, 56\u201359 (2014).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1016\/j.jbiotec.2014.07.430\" data-track-item_id=\"10.1016\/j.jbiotec.2014.07.430\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1016%2Fj.jbiotec.2014.07.430\" aria-label=\"Article reference 112\" data-doi=\"10.1016\/j.jbiotec.2014.07.430\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC2cXht1KhtbrI\" aria-label=\"CAS reference 112\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=25078432\" aria-label=\"PubMed reference 112\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 112\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Improving%20polyketide%20and%20fatty%20acid%20synthesis%20by%20engineering%20of%20the%20yeast%20acetyl-CoA%20carboxylase&amp;journal=J.%20Biotechnol.&amp;doi=10.1016%2Fj.jbiotec.2014.07.430&amp;volume=187&amp;pages=56-59&amp;publication_year=2014&amp;author=Choi%2CJW&amp;author=Silva%2CNA\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR113\">Butler, M. J. et al. Engineering of primary carbon metabolism for improved antibiotic production in Streptomyces lividans. Appl. Environ. Microbiol. 68, 4731\u20134739 (2002).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1128\/AEM.68.10.4731-4739.2002\" data-track-item_id=\"10.1128\/AEM.68.10.4731-4739.2002\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1128%2FAEM.68.10.4731-4739.2002\" aria-label=\"Article reference 113\" data-doi=\"10.1128\/AEM.68.10.4731-4739.2002\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DC%2BD38XnvFClt7w%3D\" aria-label=\"CAS reference 113\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=12324314\" aria-label=\"PubMed reference 113\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC126421\" aria-label=\"PubMed Central reference 113\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 113\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Engineering%20of%20primary%20carbon%20metabolism%20for%20improved%20antibiotic%20production%20in%20Streptomyces%20lividans&amp;journal=Appl.%20Environ.%20Microbiol.&amp;doi=10.1128%2FAEM.68.10.4731-4739.2002&amp;volume=68&amp;pages=4731-4739&amp;publication_year=2002&amp;author=Butler%2CMJ\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR114\">Rokem, J. S., Lantz, A. E. &amp; Nielsen, J. Systems biology of antibiotic production by microorganisms. Nat. Prod. Rep. 24, 1262\u20131287 (2007).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1039\/b617765b\" data-track-item_id=\"10.1039\/b617765b\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1039%2Fb617765b\" aria-label=\"Article reference 114\" data-doi=\"10.1039\/b617765b\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DC%2BD2sXhtlemsbjF\" aria-label=\"CAS reference 114\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=18033579\" aria-label=\"PubMed reference 114\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 114\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Systems%20biology%20of%20antibiotic%20production%20by%20microorganisms&amp;journal=Nat.%20Prod.%20Rep.&amp;doi=10.1039%2Fb617765b&amp;volume=24&amp;pages=1262-1287&amp;publication_year=2007&amp;author=Rokem%2CJS&amp;author=Lantz%2CAE&amp;author=Nielsen%2CJ\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR115\">Borodina, I. et al. Antibiotic Overproduction in Streptomyces coelicolor A3(2) Mediated by Phosphofructokinase Deletion*. J. Biol. Chem. 283, 25186\u201325199 (2008).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1074\/jbc.M803105200\" data-track-item_id=\"10.1074\/jbc.M803105200\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1074%2Fjbc.M803105200\" aria-label=\"Article reference 115\" data-doi=\"10.1074\/jbc.M803105200\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DC%2BD1cXhtVyisL3I\" aria-label=\"CAS reference 115\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=18606812\" aria-label=\"PubMed reference 115\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 115\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Antibiotic%20Overproduction%20in%20Streptomyces%20coelicolor%20A3%282%29%20Mediated%20by%20Phosphofructokinase%20Deletion%2A&amp;journal=J.%20Biol.%20Chem.&amp;doi=10.1074%2Fjbc.M803105200&amp;volume=283&amp;pages=25186-25199&amp;publication_year=2008&amp;author=Borodina%2CI\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR116\">Hui, S. et al. Quantitative proteomic analysis reveals a simple strategy of global resource allocation in bacteria. Mol. Syst. Biol. 11, MSB145697 (2015).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.15252\/msb.20145697\" data-track-item_id=\"10.15252\/msb.20145697\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.15252%2Fmsb.20145697\" aria-label=\"Article reference 116\" data-doi=\"10.15252\/msb.20145697\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 116\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Quantitative%20proteomic%20analysis%20reveals%20a%20simple%20strategy%20of%20global%20resource%20allocation%20in%20bacteria&amp;journal=Mol.%20Syst.%20Biol.&amp;doi=10.15252%2Fmsb.20145697&amp;volume=11&amp;publication_year=2015&amp;author=Hui%2CS\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR117\">Snoeck, S., Guidi, C. &amp; De Mey, M. Metabolic burden\u201d explained: stress symptoms and its related responses induced by (over)expression of (heterologous) proteins in Escherichia coli. Microb. Cell Fact. 23, 96 (2024).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"noopener nofollow\" data-track-label=\"10.1186\/s12934-024-02370-9\" data-track-item_id=\"10.1186\/s12934-024-02370-9\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/link.springer.com\/doi\/10.1186\/s12934-024-02370-9\" aria-label=\"Article reference 117\" data-doi=\"10.1186\/s12934-024-02370-9\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=38555441\" aria-label=\"PubMed reference 117\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC10981312\" aria-label=\"PubMed Central reference 117\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 117\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Metabolic%20burden%E2%80%9D%20explained%3A%20stress%20symptoms%20and%20its%20related%20responses%20induced%20by%20%28over%29expression%20of%20%28heterologous%29%20proteins%20in%20Escherichia%20coli&amp;journal=Microb.%20Cell%20Fact.&amp;doi=10.1186%2Fs12934-024-02370-9&amp;volume=23&amp;publication_year=2024&amp;author=Snoeck%2CS&amp;author=Guidi%2CC&amp;author=Mey%2CM\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR118\">Ruiz-Villaf\u00e1n, B. et al. Carbon catabolite regulation of secondary metabolite formation, an old but not well-established regulatory system. Microb. Biotechnol. 15, 1058\u20131072 (2022).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1111\/1751-7915.13791\" data-track-item_id=\"10.1111\/1751-7915.13791\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1111%2F1751-7915.13791\" aria-label=\"Article reference 118\" data-doi=\"10.1111\/1751-7915.13791\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=33675560\" aria-label=\"PubMed reference 118\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 118\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Carbon%20catabolite%20regulation%20of%20secondary%20metabolite%20formation%2C%20an%20old%20but%20not%20well-established%20regulatory%20system&amp;journal=Microb.%20Biotechnol.&amp;doi=10.1111%2F1751-7915.13791&amp;volume=15&amp;pages=1058-1072&amp;publication_year=2022&amp;author=Ruiz-Villaf%C3%A1n%2CB\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR119\">Sola-Landa, A., Moura, R. S. &amp; Mart\u00edn, J. F. The two-component PhoR-PhoP system controls both primary metabolism and secondary metabolite biosynthesis in Streptomyces lividans. Proc. Natl. Acad. Sci. 100, 6133\u20136138 (2003).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1073\/pnas.0931429100\" data-track-item_id=\"10.1073\/pnas.0931429100\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1073%2Fpnas.0931429100\" aria-label=\"Article reference 119\" data-doi=\"10.1073\/pnas.0931429100\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DC%2BD3sXjvFOltbY%3D\" aria-label=\"CAS reference 119\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=12730372\" aria-label=\"PubMed reference 119\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC156338\" aria-label=\"PubMed Central reference 119\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 119\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=The%20two-component%20PhoR-PhoP%20system%20controls%20both%20primary%20metabolism%20and%20secondary%20metabolite%20biosynthesis%20in%20Streptomyces%20lividans&amp;journal=Proc.%20Natl.%20Acad.%20Sci.&amp;doi=10.1073%2Fpnas.0931429100&amp;volume=100&amp;pages=6133-6138&amp;publication_year=2003&amp;author=Sola-Landa%2CA&amp;author=Moura%2CRS&amp;author=Mart%C3%ADn%2CJF\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR120\">Tudzynski, B. Nitrogen regulation of fungal secondary metabolism in fungi. Front. Microbiol. 5, 656 (2014).<\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR121\">Li, R. &amp; Townsend, C. A. Rational strain improvement for enhanced clavulanic acid production by genetic engineering of the glycolytic pathway in Streptomyces clavuligerus. Metab. Eng. 8, 240\u2013252 (2006).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1016\/j.ymben.2006.01.003\" data-track-item_id=\"10.1016\/j.ymben.2006.01.003\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1016%2Fj.ymben.2006.01.003\" aria-label=\"Article reference 121\" data-doi=\"10.1016\/j.ymben.2006.01.003\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DC%2BD28XjvVGgsbw%3D\" aria-label=\"CAS reference 121\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=16530442\" aria-label=\"PubMed reference 121\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 121\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Rational%20strain%20improvement%20for%20enhanced%20clavulanic%20acid%20production%20by%20genetic%20engineering%20of%20the%20glycolytic%20pathway%20in%20Streptomyces%20clavuligerus&amp;journal=Metab.%20Eng.&amp;doi=10.1016%2Fj.ymben.2006.01.003&amp;volume=8&amp;pages=240-252&amp;publication_year=2006&amp;author=Li%2CR&amp;author=Townsend%2CCA\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR122\">Wang, J. et al. Structural basis for the biosynthesis of lovastatin. Nat. Commun. 12, 867 (2021).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1038\/s41467-021-21174-8\" data-track-item_id=\"10.1038\/s41467-021-21174-8\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1038%2Fs41467-021-21174-8\" aria-label=\"Article reference 122\" data-doi=\"10.1038\/s41467-021-21174-8\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB3MXjvFKit7c%3D\" aria-label=\"CAS reference 122\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=33558520\" aria-label=\"PubMed reference 122\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7870829\" aria-label=\"PubMed Central reference 122\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 122\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Structural%20basis%20for%20the%20biosynthesis%20of%20lovastatin&amp;journal=Nat.%20Commun.&amp;doi=10.1038%2Fs41467-021-21174-8&amp;volume=12&amp;publication_year=2021&amp;author=Wang%2CJ\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR123\">Hendrickson, L. et al. Lovastatin biosynthesis in Aspergillus terreus: Characterization of blocked mutants, enzyme activities and a multifunctional polyketide synthase gene. Chem. Biol. 6, 429\u2013439 (1999).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1016\/S1074-5521(99)80061-1\" data-track-item_id=\"10.1016\/S1074-5521(99)80061-1\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1016%2FS1074-5521%2899%2980061-1\" aria-label=\"Article reference 123\" data-doi=\"10.1016\/S1074-5521(99)80061-1\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DyaK1MXksFKrt78%3D\" aria-label=\"CAS reference 123\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=10381407\" aria-label=\"PubMed reference 123\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 123\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Lovastatin%20biosynthesis%20in%20Aspergillus%20terreus%3A%20Characterization%20of%20blocked%20mutants%2C%20enzyme%20activities%20and%20a%20multifunctional%20polyketide%20synthase%20gene&amp;journal=Chem.%20Biol.&amp;doi=10.1016%2FS1074-5521%2899%2980061-1&amp;volume=6&amp;pages=429-439&amp;publication_year=1999&amp;author=Hendrickson%2CL\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR124\">S. Moore, B. &amp; Hertweck, C. Biosynthesis and attachment of novel bacterial polyketide synthase starter units. <a href=\"https:\/\/doi.org\/10.1039\/B003939J\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.1039\/B003939J\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.1039\/B003939J<\/a> (2002).<\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR125\">Shende, V. V., Bauman, K. D. &amp; Moore, B. S. The shikimate pathway: gateway to metabolic diversity. Nat. Prod. Rep. 41, 604\u2013648 (2024).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1039\/D3NP00037K\" data-track-item_id=\"10.1039\/D3NP00037K\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1039%2FD3NP00037K\" aria-label=\"Article reference 125\" data-doi=\"10.1039\/D3NP00037K\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB2cXkslektA%3D%3D\" aria-label=\"CAS reference 125\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=38170905\" aria-label=\"PubMed reference 125\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC11043010\" aria-label=\"PubMed Central reference 125\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 125\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=The%20shikimate%20pathway%3A%20gateway%20to%20metabolic%20diversity&amp;journal=Nat.%20Prod.%20Rep.&amp;doi=10.1039%2FD3NP00037K&amp;volume=41&amp;pages=604-648&amp;publication_year=2024&amp;author=Shende%2CVV&amp;author=Bauman%2CKD&amp;author=Moore%2CBS\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR126\">Li, Y., Liang, S., Wang, J., Ma, D. &amp; Wen, J. Enhancing the production of tacrolimus by engineering target genes identified in important primary and secondary metabolic pathways and feeding exogenous precursors. Bioprocess Biosyst. Eng. 42, 1081\u20131098 (2019).<\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR127\">Schulz, S. et al. Optimization of the precursor supply for an enhanced FK506 production in Streptomyces tsukubaensis. Front. Bioeng. Biotechnol. 10, 1067467 (2022).<\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR128\">Liras, P. &amp; Rodr\u00edguez-Garc\u00eda, A. Clavulanic acid, a \u03b2-lactamase inhibitor: biosynthesis and molecular genetics. Appl. Microbiol. Biotechnol. 54, 467\u2013475 (2000).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"noopener nofollow\" data-track-label=\"10.1007\/s002530000420\" data-track-item_id=\"10.1007\/s002530000420\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/link.springer.com\/doi\/10.1007\/s002530000420\" aria-label=\"Article reference 128\" data-doi=\"10.1007\/s002530000420\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DC%2BD3cXotFKgsbg%3D\" aria-label=\"CAS reference 128\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=11092620\" aria-label=\"PubMed reference 128\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 128\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Clavulanic%20acid%2C%20a%20%CE%B2-lactamase%20inhibitor%3A%20biosynthesis%20and%20molecular%20genetics&amp;journal=Appl.%20Microbiol.%20Biotechnol.&amp;doi=10.1007%2Fs002530000420&amp;volume=54&amp;pages=467-475&amp;publication_year=2000&amp;author=Liras%2CP&amp;author=Rodr%C3%ADguez-Garc%C3%ADa%2CA\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR129\">Zhang, J. J., Tang, X. &amp; Moore, B. S. Genetic platforms for heterologous expression of microbial natural products. Nat. Prod. Rep. 36, 1313\u20131332 (2019).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1039\/C9NP00025A\" data-track-item_id=\"10.1039\/C9NP00025A\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1039%2FC9NP00025A\" aria-label=\"Article reference 129\" data-doi=\"10.1039\/C9NP00025A\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC1MXhtF2gt7fL\" aria-label=\"CAS reference 129\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=31197291\" aria-label=\"PubMed reference 129\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6750982\" aria-label=\"PubMed Central reference 129\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 129\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Genetic%20platforms%20for%20heterologous%20expression%20of%20microbial%20natural%20products&amp;journal=Nat.%20Prod.%20Rep.&amp;doi=10.1039%2FC9NP00025A&amp;volume=36&amp;pages=1313-1332&amp;publication_year=2019&amp;author=Zhang%2CJJ&amp;author=Tang%2CX&amp;author=Moore%2CBS\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR130\">Wang, C., Cao, Y., Wang, Y., Sun, L. &amp; Song, H. Enhancing surfactin production by using systematic CRISPRi repression to screen amino acid biosynthesis genes in Bacillus subtilis. Microb. Cell Factories 18, 90 (2019).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"noopener nofollow\" data-track-label=\"10.1186\/s12934-019-1139-4\" data-track-item_id=\"10.1186\/s12934-019-1139-4\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/link.springer.com\/doi\/10.1186\/s12934-019-1139-4\" aria-label=\"Article reference 130\" data-doi=\"10.1186\/s12934-019-1139-4\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 130\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Enhancing%20surfactin%20production%20by%20using%20systematic%20CRISPRi%20repression%20to%20screen%20amino%20acid%20biosynthesis%20genes%20in%20Bacillus%20subtilis&amp;journal=Microb.%20Cell%20Factories&amp;doi=10.1186%2Fs12934-019-1139-4&amp;volume=18&amp;publication_year=2019&amp;author=Wang%2CC&amp;author=Cao%2CY&amp;author=Wang%2CY&amp;author=Sun%2CL&amp;author=Song%2CH\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR131\">Shao, M., Xu, F., Ke, X., Huang, M. &amp; Chu, J. Enhancing erythromycin production in Saccharopolyspora erythraea through rational engineering and fermentation refinement: A Design-Build-Test-Learn approach. Biotechnol. J. 19, 2400039 (2024).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1002\/biot.202400039\" data-track-item_id=\"10.1002\/biot.202400039\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1002%2Fbiot.202400039\" aria-label=\"Article reference 131\" data-doi=\"10.1002\/biot.202400039\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB2cXhtFGqu7nK\" aria-label=\"CAS reference 131\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 131\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Enhancing%20erythromycin%20production%20in%20Saccharopolyspora%20erythraea%20through%20rational%20engineering%20and%20fermentation%20refinement%3A%20A%20Design-Build-Test-Learn%20approach&amp;journal=Biotechnol.%20J.&amp;doi=10.1002%2Fbiot.202400039&amp;volume=19&amp;publication_year=2024&amp;author=Shao%2CM&amp;author=Xu%2CF&amp;author=Ke%2CX&amp;author=Huang%2CM&amp;author=Chu%2CJ\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR132\">Zha, W., Rubin-Pitel, S. B., Shao, Z. &amp; Zhao, H. Improving cellular malonyl-CoA level in Escherichia coli via metabolic engineering. Metab. Eng. 11, 192\u2013198 (2009).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1016\/j.ymben.2009.01.005\" data-track-item_id=\"10.1016\/j.ymben.2009.01.005\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1016%2Fj.ymben.2009.01.005\" aria-label=\"Article reference 132\" data-doi=\"10.1016\/j.ymben.2009.01.005\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DC%2BD1MXktlylsbY%3D\" aria-label=\"CAS reference 132\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=19558964\" aria-label=\"PubMed reference 132\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 132\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Improving%20cellular%20malonyl-CoA%20level%20in%20Escherichia%20coli%20via%20metabolic%20engineering&amp;journal=Metab.%20Eng.&amp;doi=10.1016%2Fj.ymben.2009.01.005&amp;volume=11&amp;pages=192-198&amp;publication_year=2009&amp;author=Zha%2CW&amp;author=Rubin-Pitel%2CSB&amp;author=Shao%2CZ&amp;author=Zhao%2CH\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR133\">Duban, M., Cociancich, S. &amp; Lecl\u00e8re, V. Nonribosomal Peptide Synthesis Definitely Working Out of the Rules. Microorganisms 10, 577 (2022).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.3390\/microorganisms10030577\" data-track-item_id=\"10.3390\/microorganisms10030577\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.3390%2Fmicroorganisms10030577\" aria-label=\"Article reference 133\" data-doi=\"10.3390\/microorganisms10030577\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB38XhtVCmsbjN\" aria-label=\"CAS reference 133\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=35336152\" aria-label=\"PubMed reference 133\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8949500\" aria-label=\"PubMed Central reference 133\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 133\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Nonribosomal%20Peptide%20Synthesis%20Definitely%20Working%20Out%20of%20the%20Rules&amp;journal=Microorganisms&amp;doi=10.3390%2Fmicroorganisms10030577&amp;volume=10&amp;publication_year=2022&amp;author=Duban%2CM&amp;author=Cociancich%2CS&amp;author=Lecl%C3%A8re%2CV\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR134\">Kastberg, L. L. B., Ard, R., Jensen, M. K. &amp; Workman, C. T. Burden imposed by heterologous protein production in two major industrial yeast cell factories: identifying sources and mitigation strategies. Front. Fungal Biol. 3, 827704 (2022).<\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR135\">Onaka, H., Mori, Y., Igarashi, Y. &amp; Furumai, T. Mycolic acid-containing bacteria induce natural-product biosynthesis in streptomyces species. Appl. Environ. Microbiol. 77, 400\u2013406 (2011).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1128\/AEM.01337-10\" data-track-item_id=\"10.1128\/AEM.01337-10\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1128%2FAEM.01337-10\" aria-label=\"Article reference 135\" data-doi=\"10.1128\/AEM.01337-10\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC3MXisVOqs7Y%3D\" aria-label=\"CAS reference 135\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=21097597\" aria-label=\"PubMed reference 135\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 135\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Mycolic%20acid-containing%20bacteria%20induce%20natural-product%20biosynthesis%20in%20streptomyces%20species&amp;journal=Appl.%20Environ.%20Microbiol.&amp;doi=10.1128%2FAEM.01337-10&amp;volume=77&amp;pages=400-406&amp;publication_year=2011&amp;author=Onaka%2CH&amp;author=Mori%2CY&amp;author=Igarashi%2CY&amp;author=Furumai%2CT\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR136\">Liu, C. &amp; Kakeya, H. Cryptic chemical communication: secondary metabolic responses revealed by microbial co-culture. Chem. \u2013 Asian J. 15, 327\u2013337 (2020).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1002\/asia.201901505\" data-track-item_id=\"10.1002\/asia.201901505\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1002%2Fasia.201901505\" aria-label=\"Article reference 136\" data-doi=\"10.1002\/asia.201901505\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB3cXhsFSrs7g%3D\" aria-label=\"CAS reference 136\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=31957936\" aria-label=\"PubMed reference 136\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 136\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Cryptic%20chemical%20communication%3A%20secondary%20metabolic%20responses%20revealed%20by%20microbial%20co-culture&amp;journal=Chem.%20%E2%80%93%20Asian%20J.&amp;doi=10.1002%2Fasia.201901505&amp;volume=15&amp;pages=327-337&amp;publication_year=2020&amp;author=Liu%2CC&amp;author=Kakeya%2CH\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR137\">Feng, G. H. &amp; Leonard, T. J. Culture conditions control expression of the genes for Aflatoxin and Sterigmatocystin biosynthesis in Aspergillus parasiticus and A. nidulans. Appl. Environ. Microbiol. 64, 2275\u20132277 (1998).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1128\/AEM.64.6.2275-2277.1998\" data-track-item_id=\"10.1128\/AEM.64.6.2275-2277.1998\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1128%2FAEM.64.6.2275-2277.1998\" aria-label=\"Article reference 137\" data-doi=\"10.1128\/AEM.64.6.2275-2277.1998\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DyaK1cXjslWht7g%3D\" aria-label=\"CAS reference 137\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=9603849\" aria-label=\"PubMed reference 137\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC106313\" aria-label=\"PubMed Central reference 137\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 137\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Culture%20conditions%20control%20expression%20of%20the%20genes%20for%20Aflatoxin%20and%20Sterigmatocystin%20biosynthesis%20in%20Aspergillus%20parasiticus%20and%20A.%20nidulans&amp;journal=Appl.%20Environ.%20Microbiol.&amp;doi=10.1128%2FAEM.64.6.2275-2277.1998&amp;volume=64&amp;pages=2275-2277&amp;publication_year=1998&amp;author=Feng%2CGH&amp;author=Leonard%2CTJ\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR138\">Santamaria, G. et al. Evolution and regulation of microbial secondary metabolism. eLife 11, e76119 (2022).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.7554\/eLife.76119\" data-track-item_id=\"10.7554\/eLife.76119\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.7554%2FeLife.76119\" aria-label=\"Article reference 138\" data-doi=\"10.7554\/eLife.76119\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB3sXisVKkt7%2FL\" aria-label=\"CAS reference 138\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=36409069\" aria-label=\"PubMed reference 138\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9708071\" aria-label=\"PubMed Central reference 138\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 138\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Evolution%20and%20regulation%20of%20microbial%20secondary%20metabolism&amp;journal=eLife&amp;doi=10.7554%2FeLife.76119&amp;volume=11&amp;publication_year=2022&amp;author=Santamaria%2CG\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR139\">Schniete, J. K. et al. Expanding primary metabolism helps generate the metabolic robustness to facilitate antibiotic biosynthesis in Streptomyces. mBio 9, <a href=\"https:\/\/doi.org\/10.1128\/mbio.02283-17\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.1128\/mbio.02283-17\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.1128\/mbio.02283-17<\/a> (2018).<\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR140\">Mao, D., Yoshimura, A., Wang, R. &amp; Seyedsayamdost, M. R. Reporter-guided transposon mutant selection for activation of silent gene clusters in Burkholderia thailandensis. ChemBioChem 21, 1826\u20131831 (2020).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1002\/cbic.201900748\" data-track-item_id=\"10.1002\/cbic.201900748\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1002%2Fcbic.201900748\" aria-label=\"Article reference 140\" data-doi=\"10.1002\/cbic.201900748\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB3cXktVKnsLk%3D\" aria-label=\"CAS reference 140\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=31984619\" aria-label=\"PubMed reference 140\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7493819\" aria-label=\"PubMed Central reference 140\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 140\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Reporter-guided%20transposon%20mutant%20selection%20for%20activation%20of%20silent%20gene%20clusters%20in%20Burkholderia%20thailandensis&amp;journal=ChemBioChem&amp;doi=10.1002%2Fcbic.201900748&amp;volume=21&amp;pages=1826-1831&amp;publication_year=2020&amp;author=Mao%2CD&amp;author=Yoshimura%2CA&amp;author=Wang%2CR&amp;author=Seyedsayamdost%2CMR\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR141\">Yoshimura, A. et al. Unlocking cryptic metabolites with mass spectrometry-guided transposon mutant selection. ACS Chem. Biol. 15, 2766\u20132774 (2020).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1021\/acschembio.0c00558\" data-track-item_id=\"10.1021\/acschembio.0c00558\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1021%2Facschembio.0c00558\" aria-label=\"Article reference 141\" data-doi=\"10.1021\/acschembio.0c00558\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB3cXhs1aqsLrJ\" aria-label=\"CAS reference 141\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=32808751\" aria-label=\"PubMed reference 141\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7572862\" aria-label=\"PubMed Central reference 141\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 141\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Unlocking%20cryptic%20metabolites%20with%20mass%20spectrometry-guided%20transposon%20mutant%20selection&amp;journal=ACS%20Chem.%20Biol.&amp;doi=10.1021%2Facschembio.0c00558&amp;volume=15&amp;pages=2766-2774&amp;publication_year=2020&amp;author=Yoshimura%2CA\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR142\">Fedashchin, A. et al. Random transposon mutagenesis of the Saccharopolyspora erythraea genome reveals additional genes influencing erythromycin biosynthesis. FEMS Microbiol. Lett. 362, fnv180 (2015).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1093\/femsle\/fnv180\" data-track-item_id=\"10.1093\/femsle\/fnv180\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1093%2Ffemsle%2Ffnv180\" aria-label=\"Article reference 142\" data-doi=\"10.1093\/femsle\/fnv180\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=26468041\" aria-label=\"PubMed reference 142\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4809991\" aria-label=\"PubMed Central reference 142\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 142\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Random%20transposon%20mutagenesis%20of%20the%20Saccharopolyspora%20erythraea%20genome%20reveals%20additional%20genes%20influencing%20erythromycin%20biosynthesis&amp;journal=FEMS%20Microbiol.%20Lett.&amp;doi=10.1093%2Ffemsle%2Ffnv180&amp;volume=362&amp;publication_year=2015&amp;author=Fedashchin%2CA\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR143\">Guzm\u00e1n-Ch\u00e1vez, F., Zwahlen, R. D., Bovenberg, R. A. L. &amp; Driessen, A. J. M. Engineering of the Filamentous Fungus Penicillium chrysogenum as Cell Factory for Natural Products. Front. Microbiol. 9, 2768 (2018).<\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR144\">McCarty, N. S., Graham, A. E., Studen\u00e1, L. &amp; Ledesma-Amaro, R. Multiplexed CRISPR technologies for gene editing and transcriptional regulation. Nat. Commun. 11, 1281 (2020).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1038\/s41467-020-15053-x\" data-track-item_id=\"10.1038\/s41467-020-15053-x\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1038%2Fs41467-020-15053-x\" aria-label=\"Article reference 144\" data-doi=\"10.1038\/s41467-020-15053-x\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB3cXlt1Sgsrs%3D\" aria-label=\"CAS reference 144\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=32152313\" aria-label=\"PubMed reference 144\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7062760\" aria-label=\"PubMed Central reference 144\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 144\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Multiplexed%20CRISPR%20technologies%20for%20gene%20editing%20and%20transcriptional%20regulation&amp;journal=Nat.%20Commun.&amp;doi=10.1038%2Fs41467-020-15053-x&amp;volume=11&amp;publication_year=2020&amp;author=McCarty%2CNS&amp;author=Graham%2CAE&amp;author=Studen%C3%A1%2CL&amp;author=Ledesma-Amaro%2CR\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR145\">Zhao, Y. et al. CRISPR\/dCas9-mediated multiplex gene repression in Streptomyces. Biotechnol. J. 13, 1800121 (2018).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1002\/biot.201800121\" data-track-item_id=\"10.1002\/biot.201800121\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1002%2Fbiot.201800121\" aria-label=\"Article reference 145\" data-doi=\"10.1002\/biot.201800121\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 145\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=CRISPR%2FdCas9-mediated%20multiplex%20gene%20repression%20in%20Streptomyces&amp;journal=Biotechnol.%20J.&amp;doi=10.1002%2Fbiot.201800121&amp;volume=13&amp;publication_year=2018&amp;author=Zhao%2CY\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR146\">Baral, B., Akhgari, A. &amp; Mets\u00e4-Ketel\u00e4, M. Activation of microbial secondary metabolic pathways: Avenues and challenges. Synth. Syst. Biotechnol. 3, 163\u2013178 (2018).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1016\/j.synbio.2018.09.001\" data-track-item_id=\"10.1016\/j.synbio.2018.09.001\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1016%2Fj.synbio.2018.09.001\" aria-label=\"Article reference 146\" data-doi=\"10.1016\/j.synbio.2018.09.001\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=30345402\" aria-label=\"PubMed reference 146\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6190515\" aria-label=\"PubMed Central reference 146\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 146\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Activation%20of%20microbial%20secondary%20metabolic%20pathways%3A%20Avenues%20and%20challenges&amp;journal=Synth.%20Syst.%20Biotechnol.&amp;doi=10.1016%2Fj.synbio.2018.09.001&amp;volume=3&amp;pages=163-178&amp;publication_year=2018&amp;author=Baral%2CB&amp;author=Akhgari%2CA&amp;author=Mets%C3%A4-Ketel%C3%A4%2CM\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR147\">Sharp, P. M. &amp; Li, W.-H. The codon adaptation index-a measure of directional synonymous codon usage bias, and its potential applications. Nucleic Acids Res 15, 1281\u20131295 (1987).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1093\/nar\/15.3.1281\" data-track-item_id=\"10.1093\/nar\/15.3.1281\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1093%2Fnar%2F15.3.1281\" aria-label=\"Article reference 147\" data-doi=\"10.1093\/nar\/15.3.1281\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DyaL2sXhtlejtrc%3D\" aria-label=\"CAS reference 147\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=3547335\" aria-label=\"PubMed reference 147\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC340524\" aria-label=\"PubMed Central reference 147\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 147\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=The%20codon%20adaptation%20index-a%20measure%20of%20directional%20synonymous%20codon%20usage%20bias%2C%20and%20its%20potential%20applications&amp;journal=Nucleic%20Acids%20Res&amp;doi=10.1093%2Fnar%2F15.3.1281&amp;volume=15&amp;pages=1281-1295&amp;publication_year=1987&amp;author=Sharp%2CPM&amp;author=Li%2CW-H\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR148\">Liu, Y. A code within the genetic code: codon usage regulates co-translational protein folding. Cell Commun. Signal. 18, 145 (2020).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"noopener nofollow\" data-track-label=\"10.1186\/s12964-020-00642-6\" data-track-item_id=\"10.1186\/s12964-020-00642-6\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/link.springer.com\/doi\/10.1186\/s12964-020-00642-6\" aria-label=\"Article reference 148\" data-doi=\"10.1186\/s12964-020-00642-6\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB3cXhvFKnsLfN\" aria-label=\"CAS reference 148\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=32907610\" aria-label=\"PubMed reference 148\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7488015\" aria-label=\"PubMed Central reference 148\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 148\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=A%20code%20within%20the%20genetic%20code%3A%20codon%20usage%20regulates%20co-translational%20protein%20folding&amp;journal=Cell%20Commun.%20Signal.&amp;doi=10.1186%2Fs12964-020-00642-6&amp;volume=18&amp;publication_year=2020&amp;author=Liu%2CY\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR149\">Nah, H.-J., Pyeon, H.-R., Kang, S.-H., Choi, S.-S. &amp; Kim, E.-S. Cloning and heterologous expression of a large-sized natural product biosynthetic gene cluster in Streptomyces species. Front. Microbiol. 8, 394 (2017).<\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR150\">Bekiesch, P., Basitta, P. &amp; Apel, A. K. Challenges in the heterologous production of antibiotics in Streptomyces. Arch. Pharm. 349, 594\u2013601 (2016).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1002\/ardp.201600058\" data-track-item_id=\"10.1002\/ardp.201600058\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1002%2Fardp.201600058\" aria-label=\"Article reference 150\" data-doi=\"10.1002\/ardp.201600058\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC28XptVGmsbk%3D\" aria-label=\"CAS reference 150\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 150\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Challenges%20in%20the%20heterologous%20production%20of%20antibiotics%20in%20Streptomyces&amp;journal=Arch.%20Pharm.&amp;doi=10.1002%2Fardp.201600058&amp;volume=349&amp;pages=594-601&amp;publication_year=2016&amp;author=Bekiesch%2CP&amp;author=Basitta%2CP&amp;author=Apel%2CAK\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR151\">Teijaro, C. N., Adhikari, A. &amp; Shen, B. Challenges and opportunities for natural product discovery, production, and engineering in native producers versus heterologous hosts. J. Ind. Microbiol. Biotechnol. 46, 433\u2013444 (2019).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"noopener nofollow\" data-track-label=\"10.1007\/s10295-018-2094-5\" data-track-item_id=\"10.1007\/s10295-018-2094-5\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/link.springer.com\/doi\/10.1007\/s10295-018-2094-5\" aria-label=\"Article reference 151\" data-doi=\"10.1007\/s10295-018-2094-5\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC1cXit1SgtbvE\" aria-label=\"CAS reference 151\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=30426283\" aria-label=\"PubMed reference 151\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 151\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Challenges%20and%20opportunities%20for%20natural%20product%20discovery%2C%20production%2C%20and%20engineering%20in%20native%20producers%20versus%20heterologous%20hosts&amp;journal=J.%20Ind.%20Microbiol.%20Biotechnol.&amp;doi=10.1007%2Fs10295-018-2094-5&amp;volume=46&amp;pages=433-444&amp;publication_year=2019&amp;author=Teijaro%2CCN&amp;author=Adhikari%2CA&amp;author=Shen%2CB\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR152\">Sharma, R., Evans, P. A. &amp; Bhavsar, V. C. Regulatory link mapping between organisms. BMC Syst. Biol. 5, S4 (2011).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"noopener nofollow\" data-track-label=\"10.1186\/1752-0509-5-S1-S4\" data-track-item_id=\"10.1186\/1752-0509-5-S1-S4\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/link.springer.com\/doi\/10.1186\/1752-0509-5-S1-S4\" aria-label=\"Article reference 152\" data-doi=\"10.1186\/1752-0509-5-S1-S4\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=21689479\" aria-label=\"PubMed reference 152\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3121120\" aria-label=\"PubMed Central reference 152\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 152\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Regulatory%20link%20mapping%20between%20organisms&amp;journal=BMC%20Syst.%20Biol.&amp;doi=10.1186%2F1752-0509-5-S1-S4&amp;volume=5&amp;publication_year=2011&amp;author=Sharma%2CR&amp;author=Evans%2CPA&amp;author=Bhavsar%2CVC\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR153\">Blin, K. et al. antiSMASH 8.0: extended gene cluster detection capabilities and analyses of chemistry, enzymology, and regulation. Nucleic Acids Res. 53, W32\u2013W38 (2025).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1093\/nar\/gkaf334\" data-track-item_id=\"10.1093\/nar\/gkaf334\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1093%2Fnar%2Fgkaf334\" aria-label=\"Article reference 153\" data-doi=\"10.1093\/nar\/gkaf334\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=40276974\" aria-label=\"PubMed reference 153\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC12230676\" aria-label=\"PubMed Central reference 153\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 153\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=antiSMASH%208.0%3A%20extended%20gene%20cluster%20detection%20capabilities%20and%20analyses%20of%20chemistry%2C%20enzymology%2C%20and%20regulation&amp;journal=Nucleic%20Acids%20Res.&amp;doi=10.1093%2Fnar%2Fgkaf334&amp;volume=53&amp;pages=W32-W38&amp;publication_year=2025&amp;author=Blin%2CK\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR154\">Hannigan, G. D. et al. A deep learning genome-mining strategy for biosynthetic gene cluster prediction. Nucleic Acids Res. 47, e110 (2019).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1093\/nar\/gkz654\" data-track-item_id=\"10.1093\/nar\/gkz654\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1093%2Fnar%2Fgkz654\" aria-label=\"Article reference 154\" data-doi=\"10.1093\/nar\/gkz654\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB3cXhtVSkt7jI\" aria-label=\"CAS reference 154\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=31400112\" aria-label=\"PubMed reference 154\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6765103\" aria-label=\"PubMed Central reference 154\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 154\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=A%20deep%20learning%20genome-mining%20strategy%20for%20biosynthetic%20gene%20cluster%20prediction&amp;journal=Nucleic%20Acids%20Res.&amp;doi=10.1093%2Fnar%2Fgkz654&amp;volume=47&amp;publication_year=2019&amp;author=Hannigan%2CGD\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR155\">Rios-Martinez, C., Bhattacharya, N., Amini, A. P., Crawford, L. &amp; Yang, K. K. Deep self-supervised learning for biosynthetic gene cluster detection and product classification. PLOS Comput. Biol. 19, e1011162 (2023).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1371\/journal.pcbi.1011162\" data-track-item_id=\"10.1371\/journal.pcbi.1011162\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1371%2Fjournal.pcbi.1011162\" aria-label=\"Article reference 155\" data-doi=\"10.1371\/journal.pcbi.1011162\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB3sXhtFGqt7vJ\" aria-label=\"CAS reference 155\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=37220151\" aria-label=\"PubMed reference 155\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC10241353\" aria-label=\"PubMed Central reference 155\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 155\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Deep%20self-supervised%20learning%20for%20biosynthetic%20gene%20cluster%20detection%20and%20product%20classification&amp;journal=PLOS%20Comput.%20Biol.&amp;doi=10.1371%2Fjournal.pcbi.1011162&amp;volume=19&amp;publication_year=2023&amp;author=Rios-Martinez%2CC&amp;author=Bhattacharya%2CN&amp;author=Amini%2CAP&amp;author=Crawford%2CL&amp;author=Yang%2CKK\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR156\">Lai, Q. et al. Deciphering the biosynthetic potential of microbial genomes using a BGC language processing neural network model. Nucleic Acids Res. 53, gkaf305 (2025).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1093\/nar\/gkaf305\" data-track-item_id=\"10.1093\/nar\/gkaf305\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1093%2Fnar%2Fgkaf305\" aria-label=\"Article reference 156\" data-doi=\"10.1093\/nar\/gkaf305\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=40226917\" aria-label=\"PubMed reference 156\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC11995264\" aria-label=\"PubMed Central reference 156\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 156\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Deciphering%20the%20biosynthetic%20potential%20of%20microbial%20genomes%20using%20a%20BGC%20language%20processing%20neural%20network%20model&amp;journal=Nucleic%20Acids%20Res.&amp;doi=10.1093%2Fnar%2Fgkaf305&amp;volume=53&amp;publication_year=2025&amp;author=Lai%2CQ\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR157\">Blin, K. et al. antiSMASH 7.0: new and improved predictions for detection, regulation, chemical structures and visualisation. Nucleic Acids Res. 51, W46\u2013W50 (2023).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1093\/nar\/gkad344\" data-track-item_id=\"10.1093\/nar\/gkad344\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1093%2Fnar%2Fgkad344\" aria-label=\"Article reference 157\" data-doi=\"10.1093\/nar\/gkad344\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB2cXksVylsLY%3D\" aria-label=\"CAS reference 157\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=37140036\" aria-label=\"PubMed reference 157\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC10320115\" aria-label=\"PubMed Central reference 157\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 157\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=antiSMASH%207.0%3A%20new%20and%20improved%20predictions%20for%20detection%2C%20regulation%2C%20chemical%20structures%20and%20visualisation&amp;journal=Nucleic%20Acids%20Res.&amp;doi=10.1093%2Fnar%2Fgkad344&amp;volume=51&amp;pages=W46-W50&amp;publication_year=2023&amp;author=Blin%2CK\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR158\">Ribeiro Monteiro, S. &amp; Rigali, S. Enhanced prediction of expression control in bacterial biosynthetic gene clusters via genomic and functional data integration. Microb. Genomics 11, 001512 (2025).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1099\/mgen.0.001512\" data-track-item_id=\"10.1099\/mgen.0.001512\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1099%2Fmgen.0.001512\" aria-label=\"Article reference 158\" data-doi=\"10.1099\/mgen.0.001512\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB2MXivFKmsbfK\" aria-label=\"CAS reference 158\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 158\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Enhanced%20prediction%20of%20expression%20control%20in%20bacterial%20biosynthetic%20gene%20clusters%20via%20genomic%20and%20functional%20data%20integration&amp;journal=Microb.%20Genomics&amp;doi=10.1099%2Fmgen.0.001512&amp;volume=11&amp;publication_year=2025&amp;author=Ribeiro%20Monteiro%2CS&amp;author=Rigali%2CS\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR159\">Spohn, M., Wohlleben, W. &amp; Stegmann, E. Elucidation of the zinc-dependent regulation in Amycolatopsis japonicum enabled the identification of the ethylenediamine-disuccinate ([S,S]-EDDS) genes. Environ. Microbiol. 18, 1249\u20131263 (2016).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1111\/1462-2920.13159\" data-track-item_id=\"10.1111\/1462-2920.13159\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1111%2F1462-2920.13159\" aria-label=\"Article reference 159\" data-doi=\"10.1111\/1462-2920.13159\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC28XmtF2ksrs%3D\" aria-label=\"CAS reference 159\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=26636770\" aria-label=\"PubMed reference 159\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 159\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Elucidation%20of%20the%20zinc-dependent%20regulation%20in%20Amycolatopsis%20japonicum%20enabled%20the%20identification%20of%20the%20ethylenediamine-disuccinate%20%28%5BS%2CS%5D-EDDS%29%20genes&amp;journal=Environ.%20Microbiol.&amp;doi=10.1111%2F1462-2920.13159&amp;volume=18&amp;pages=1249-1263&amp;publication_year=2016&amp;author=Spohn%2CM&amp;author=Wohlleben%2CW&amp;author=Stegmann%2CE\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR160\">Bajpe, H. et al. The transcriptional regulatory network of the Escherichia coli MG1655 reference strain. Nucleic Acids Res. 54, gkag059 (2026).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1093\/nar\/gkag059\" data-track-item_id=\"10.1093\/nar\/gkag059\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1093%2Fnar%2Fgkag059\" aria-label=\"Article reference 160\" data-doi=\"10.1093\/nar\/gkag059\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB28Xjt1emtbg%3D\" aria-label=\"CAS reference 160\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=41626695\" aria-label=\"PubMed reference 160\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC12862375\" aria-label=\"PubMed Central reference 160\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 160\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=The%20transcriptional%20regulatory%20network%20of%20the%20Escherichia%20coli%20MG1655%20reference%20strain&amp;journal=Nucleic%20Acids%20Res.&amp;doi=10.1093%2Fnar%2Fgkag059&amp;volume=54&amp;publication_year=2026&amp;author=Bajpe%2CH\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR161\">Rajput, A. et al. Machine learning from Pseudomonas aeruginosa transcriptomes identifies independently modulated sets of genes associated with known transcriptional regulators. Nucleic Acids Res. 50, 3658\u20133672 (2022).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1093\/nar\/gkac187\" data-track-item_id=\"10.1093\/nar\/gkac187\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1093%2Fnar%2Fgkac187\" aria-label=\"Article reference 161\" data-doi=\"10.1093\/nar\/gkac187\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB38Xhs1Klur%2FK\" aria-label=\"CAS reference 161\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=35357493\" aria-label=\"PubMed reference 161\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9023270\" aria-label=\"PubMed Central reference 161\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 161\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Machine%20learning%20from%20Pseudomonas%20aeruginosa%20transcriptomes%20identifies%20independently%20modulated%20sets%20of%20genes%20associated%20with%20known%20transcriptional%20regulators&amp;journal=Nucleic%20Acids%20Res.&amp;doi=10.1093%2Fnar%2Fgkac187&amp;volume=50&amp;pages=3658-3672&amp;publication_year=2022&amp;author=Rajput%2CA\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR162\">Rychel, K. et al. iModulonDB: a knowledgebase of microbial transcriptional regulation derived from machine learning. Nucleic Acids Res. 49, D112\u2013D120 (2021).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1093\/nar\/gkaa810\" data-track-item_id=\"10.1093\/nar\/gkaa810\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1093%2Fnar%2Fgkaa810\" aria-label=\"Article reference 162\" data-doi=\"10.1093\/nar\/gkaa810\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB3MXntlaqtb8%3D\" aria-label=\"CAS reference 162\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=33045728\" aria-label=\"PubMed reference 162\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7778901\" aria-label=\"PubMed Central reference 162\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 162\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=iModulonDB%3A%20a%20knowledgebase%20of%20microbial%20transcriptional%20regulation%20derived%20from%20machine%20learning&amp;journal=Nucleic%20Acids%20Res.&amp;doi=10.1093%2Fnar%2Fgkaa810&amp;volume=49&amp;pages=D112-D120&amp;publication_year=2021&amp;author=Rychel%2CK\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR163\">Breitling, R., Achcar, F. &amp; Takano, E. Modeling challenges in the synthetic biology of secondary metabolism. ACS Synth. Biol. 2, 373\u2013378 (2013).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1021\/sb4000228\" data-track-item_id=\"10.1021\/sb4000228\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1021%2Fsb4000228\" aria-label=\"Article reference 163\" data-doi=\"10.1021\/sb4000228\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC3sXnsVeqs7c%3D\" aria-label=\"CAS reference 163\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=23659212\" aria-label=\"PubMed reference 163\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 163\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Modeling%20challenges%20in%20the%20synthetic%20biology%20of%20secondary%20metabolism&amp;journal=ACS%20Synth.%20Biol.&amp;doi=10.1021%2Fsb4000228&amp;volume=2&amp;pages=373-378&amp;publication_year=2013&amp;author=Breitling%2CR&amp;author=Achcar%2CF&amp;author=Takano%2CE\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR164\">Kim, H. U., Charusanti, P., Lee, S. Y. &amp; Weber, T. Metabolic engineering with systems biology tools to optimize production of prokaryotic secondary metabolites. Nat. Prod. Rep. 33, 933\u2013941 (2016).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1039\/C6NP00019C\" data-track-item_id=\"10.1039\/C6NP00019C\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1039%2FC6NP00019C\" aria-label=\"Article reference 164\" data-doi=\"10.1039\/C6NP00019C\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC28XmsF2ks7s%3D\" aria-label=\"CAS reference 164\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=27072921\" aria-label=\"PubMed reference 164\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 164\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Metabolic%20engineering%20with%20systems%20biology%20tools%20to%20optimize%20production%20of%20prokaryotic%20secondary%20metabolites&amp;journal=Nat.%20Prod.%20Rep.&amp;doi=10.1039%2FC6NP00019C&amp;volume=33&amp;pages=933-941&amp;publication_year=2016&amp;author=Kim%2CHU&amp;author=Charusanti%2CP&amp;author=Lee%2CSY&amp;author=Weber%2CT\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR165\">Sulheim, S., Fossheim, F. A., Wentzel, A. &amp; Almaas, E. Automatic reconstruction of metabolic pathways from identified biosynthetic gene clusters. BMC Bioinforma. 22, 81 (2021).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"noopener nofollow\" data-track-label=\"10.1186\/s12859-021-03985-0\" data-track-item_id=\"10.1186\/s12859-021-03985-0\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/link.springer.com\/doi\/10.1186\/s12859-021-03985-0\" aria-label=\"Article reference 165\" data-doi=\"10.1186\/s12859-021-03985-0\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB3MXlt1altLk%3D\" aria-label=\"CAS reference 165\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 165\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Automatic%20reconstruction%20of%20metabolic%20pathways%20from%20identified%20biosynthetic%20gene%20clusters&amp;journal=BMC%20Bioinforma.&amp;doi=10.1186%2Fs12859-021-03985-0&amp;volume=22&amp;publication_year=2021&amp;author=Sulheim%2CS&amp;author=Fossheim%2CFA&amp;author=Wentzel%2CA&amp;author=Almaas%2CE\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR166\">Hemphill, C. F. P. et al. OSMAC approach leads to new fusarielin metabolites from Fusarium tricinctum. J. Antibiot. 70, 726\u2013732 (2017).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1038\/ja.2017.21\" data-track-item_id=\"10.1038\/ja.2017.21\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1038%2Fja.2017.21\" aria-label=\"Article reference 166\" data-doi=\"10.1038\/ja.2017.21\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC2sXosVykurk%3D\" aria-label=\"CAS reference 166\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 166\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=OSMAC%20approach%20leads%20to%20new%20fusarielin%20metabolites%20from%20Fusarium%20tricinctum&amp;journal=J.%20Antibiot.&amp;doi=10.1038%2Fja.2017.21&amp;volume=70&amp;pages=726-732&amp;publication_year=2017&amp;author=Hemphill%2CCFP\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR167\">Schroeckh, V. et al. Intimate bacterial\u2013fungal interaction triggers biosynthesis of archetypal polyketides in Aspergillus nidulans. Proc. Natl. Acad. Sci. 106, 14558\u201314563 (2009).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1073\/pnas.0901870106\" data-track-item_id=\"10.1073\/pnas.0901870106\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1073%2Fpnas.0901870106\" aria-label=\"Article reference 167\" data-doi=\"10.1073\/pnas.0901870106\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DC%2BD1MXhtFWku7bL\" aria-label=\"CAS reference 167\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=19666480\" aria-label=\"PubMed reference 167\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2732885\" aria-label=\"PubMed Central reference 167\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 167\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Intimate%20bacterial%E2%80%93fungal%20interaction%20triggers%20biosynthesis%20of%20archetypal%20polyketides%20in%20Aspergillus%20nidulans&amp;journal=Proc.%20Natl.%20Acad.%20Sci.&amp;doi=10.1073%2Fpnas.0901870106&amp;volume=106&amp;pages=14558-14563&amp;publication_year=2009&amp;author=Schroeckh%2CV\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR168\">Shima, J., Hesketh, A., Okamoto, S., Kawamoto, S. &amp; Ochi, K. Induction of actinorhodin production by rpsL (encoding ribosomal protein S12) mutations that confer streptomycin resistance in Streptomyces lividans and Streptomyces coelicolor A3(2). J. Bacteriol. 178, 7276\u20137284 (1996).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1128\/jb.178.24.7276-7284.1996\" data-track-item_id=\"10.1128\/jb.178.24.7276-7284.1996\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1128%2Fjb.178.24.7276-7284.1996\" aria-label=\"Article reference 168\" data-doi=\"10.1128\/jb.178.24.7276-7284.1996\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DyaK2sXhtlCktw%3D%3D\" aria-label=\"CAS reference 168\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=8955413\" aria-label=\"PubMed reference 168\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC178644\" aria-label=\"PubMed Central reference 168\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 168\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Induction%20of%20actinorhodin%20production%20by%20rpsL%20%28encoding%20ribosomal%20protein%20S12%29%20mutations%20that%20confer%20streptomycin%20resistance%20in%20Streptomyces%20lividans%20and%20Streptomyces%20coelicolor%20A3%282%29&amp;journal=J.%20Bacteriol.&amp;doi=10.1128%2Fjb.178.24.7276-7284.1996&amp;volume=178&amp;pages=7276-7284&amp;publication_year=1996&amp;author=Shima%2CJ&amp;author=Hesketh%2CA&amp;author=Okamoto%2CS&amp;author=Kawamoto%2CS&amp;author=Ochi%2CK\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR169\">Ding, Z. et al. Overexpression of global regulator Talae1 leads to the discovery of new antifungal polyketides from endophytic fungus Trichoderma afroharzianum. Front. Microbiol. 11, 622785 (2020).<\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR170\">Shwab, E. K. et al. Histone deacetylase activity regulates chemical diversity in Aspergillus. Eukaryot. Cell 6, 1656\u20131664 (2007).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1128\/EC.00186-07\" data-track-item_id=\"10.1128\/EC.00186-07\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1128%2FEC.00186-07\" aria-label=\"Article reference 170\" data-doi=\"10.1128\/EC.00186-07\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DC%2BD2sXhtVKqt7bJ\" aria-label=\"CAS reference 170\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=17616629\" aria-label=\"PubMed reference 170\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2043372\" aria-label=\"PubMed Central reference 170\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 170\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Histone%20deacetylase%20activity%20regulates%20chemical%20diversity%20in%20Aspergillus&amp;journal=Eukaryot.%20Cell&amp;doi=10.1128%2FEC.00186-07&amp;volume=6&amp;pages=1656-1664&amp;publication_year=2007&amp;author=Shwab%2CEK\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR171\">Bergmann, S. et al. Genomics-driven discovery of PKS-NRPS hybrid metabolites from Aspergillus nidulans. Nat. Chem. Biol. 3, 213\u2013217 (2007).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1038\/nchembio869\" data-track-item_id=\"10.1038\/nchembio869\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1038%2Fnchembio869\" aria-label=\"Article reference 171\" data-doi=\"10.1038\/nchembio869\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DC%2BD2sXjtFKnsrg%3D\" aria-label=\"CAS reference 171\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=17369821\" aria-label=\"PubMed reference 171\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 171\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Genomics-driven%20discovery%20of%20PKS-NRPS%20hybrid%20metabolites%20from%20Aspergillus%20nidulans&amp;journal=Nat.%20Chem.%20Biol.&amp;doi=10.1038%2Fnchembio869&amp;volume=3&amp;pages=213-217&amp;publication_year=2007&amp;author=Bergmann%2CS\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR172\">Guo, F. et al. Targeted activation of silent natural product biosynthesis pathways by reporter-guided mutant selection. Metab. Eng. 28, 134\u2013142 (2015).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1016\/j.ymben.2014.12.006\" data-track-item_id=\"10.1016\/j.ymben.2014.12.006\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1016%2Fj.ymben.2014.12.006\" aria-label=\"Article reference 172\" data-doi=\"10.1016\/j.ymben.2014.12.006\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC2MXmtVSltg%3D%3D\" aria-label=\"CAS reference 172\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=25554073\" aria-label=\"PubMed reference 172\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 172\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Targeted%20activation%20of%20silent%20natural%20product%20biosynthesis%20pathways%20by%20reporter-guided%20mutant%20selection&amp;journal=Metab.%20Eng.&amp;doi=10.1016%2Fj.ymben.2014.12.006&amp;volume=28&amp;pages=134-142&amp;publication_year=2015&amp;author=Guo%2CF\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR173\">Olano, C. et al. Activation and identification of five clusters for secondary metabolites in Streptomyces albus J1074. Microb. Biotechnol. 7, 242\u2013256 (2014).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1111\/1751-7915.12116\" data-track-item_id=\"10.1111\/1751-7915.12116\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1111%2F1751-7915.12116\" aria-label=\"Article reference 173\" data-doi=\"10.1111\/1751-7915.12116\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC2cXmtVCjs7c%3D\" aria-label=\"CAS reference 173\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=24593309\" aria-label=\"PubMed reference 173\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3992020\" aria-label=\"PubMed Central reference 173\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 173\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Activation%20and%20identification%20of%20five%20clusters%20for%20secondary%20metabolites%20in%20Streptomyces%20albus%20J1074&amp;journal=Microb.%20Biotechnol.&amp;doi=10.1111%2F1751-7915.12116&amp;volume=7&amp;pages=242-256&amp;publication_year=2014&amp;author=Olano%2CC\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR174\">Tay, D. W. P. et al. Exploring a general multi-pronged activation strategy for natural product discovery in Actinomycetes. Commun. Biol. 7, 50 (2024).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1038\/s42003-023-05648-7\" data-track-item_id=\"10.1038\/s42003-023-05648-7\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1038%2Fs42003-023-05648-7\" aria-label=\"Article reference 174\" data-doi=\"10.1038\/s42003-023-05648-7\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB2cXhtFOgtr8%3D\" aria-label=\"CAS reference 174\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=38184720\" aria-label=\"PubMed reference 174\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC10771470\" aria-label=\"PubMed Central reference 174\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 174\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Exploring%20a%20general%20multi-pronged%20activation%20strategy%20for%20natural%20product%20discovery%20in%20Actinomycetes&amp;journal=Commun.%20Biol.&amp;doi=10.1038%2Fs42003-023-05648-7&amp;volume=7&amp;publication_year=2024&amp;author=Tay%2CDWP\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR175\">Wang, X. et al. Discovery of recombinases enables genome mining of cryptic biosynthetic gene clusters in Burkholderiales species. Proc. Natl. Acad. Sci. 115, E4255\u2013E4263 (2018).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC1cXhvVGhtL7K\" aria-label=\"CAS reference 175\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=29666226\" aria-label=\"PubMed reference 175\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5939090\" aria-label=\"PubMed Central reference 175\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 175\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Discovery%20of%20recombinases%20enables%20genome%20mining%20of%20cryptic%20biosynthetic%20gene%20clusters%20in%20Burkholderiales%20species&amp;journal=Proc.%20Natl.%20Acad.%20Sci.&amp;volume=115&amp;pages=E4255-E4263&amp;publication_year=2018&amp;author=Wang%2CX\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR176\">Wang, G. et al. CRAGE enables rapid activation of biosynthetic gene clusters in undomesticated bacteria. Nat. Microbiol. 4, 2498\u20132510 (2019).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1038\/s41564-019-0573-8\" data-track-item_id=\"10.1038\/s41564-019-0573-8\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1038%2Fs41564-019-0573-8\" aria-label=\"Article reference 176\" data-doi=\"10.1038\/s41564-019-0573-8\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=31611640\" aria-label=\"PubMed reference 176\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 176\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=CRAGE%20enables%20rapid%20activation%20of%20biosynthetic%20gene%20clusters%20in%20undomesticated%20bacteria&amp;journal=Nat.%20Microbiol.&amp;doi=10.1038%2Fs41564-019-0573-8&amp;volume=4&amp;pages=2498-2510&amp;publication_year=2019&amp;author=Wang%2CG\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR177\">Siebels, I. et al. Cell-Free Synthesis of Natural Compounds from Genomic DNA of Biosynthetic Gene Clusters. ACS Synth. Biol. 9, 2418\u20132426 (2020).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1021\/acssynbio.0c00186\" data-track-item_id=\"10.1021\/acssynbio.0c00186\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1021%2Facssynbio.0c00186\" aria-label=\"Article reference 177\" data-doi=\"10.1021\/acssynbio.0c00186\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB3cXhs1CksLnO\" aria-label=\"CAS reference 177\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=32818377\" aria-label=\"PubMed reference 177\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 177\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Cell-Free%20Synthesis%20of%20Natural%20Compounds%20from%20Genomic%20DNA%20of%20Biosynthetic%20Gene%20Clusters&amp;journal=ACS%20Synth.%20Biol.&amp;doi=10.1021%2Facssynbio.0c00186&amp;volume=9&amp;pages=2418-2426&amp;publication_year=2020&amp;author=Siebels%2CI\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n","protected":false},"excerpt":{"rendered":"Schmidt, B. et al. A natural history of botanical therapeutics. Metabolism 57, S3\u2013S9 (2008). Article\u00a0 CAS\u00a0 PubMed\u00a0 PubMed&hellip;\n","protected":false},"author":2,"featured_media":547147,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[5],"tags":[248580,114,37604,3181,85,46,3183,3488],"class_list":["post-547146","post","type-post","status-publish","format-standard","has-post-thumbnail","category-business","tag-biosynthesis","tag-business","tag-computational-biology-and-bioinformatics","tag-general","tag-il","tag-israel","tag-life-sciences","tag-microbiology"],"_links":{"self":[{"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/posts\/547146","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/comments?post=547146"}],"version-history":[{"count":0,"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/posts\/547146\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/media\/547147"}],"wp:attachment":[{"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/media?parent=547146"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/categories?post=547146"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/tags?post=547146"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}