{"id":552220,"date":"2026-07-21T11:54:10","date_gmt":"2026-07-21T11:54:10","guid":{"rendered":"https:\/\/www.newsbeep.com\/il\/552220\/"},"modified":"2026-07-21T11:54:10","modified_gmt":"2026-07-21T11:54:10","slug":"colitis-protection-through-apiin-pathways-emj","status":"publish","type":"post","link":"https:\/\/www.newsbeep.com\/il\/552220\/","title":{"rendered":"Colitis Protection through Apiin Pathways \u2013 EMJ"},"content":{"rendered":"

COLITIS<\/a>\u00a0protection was associated with microbiota dependent\u00a0apiin\u00a0activity, with new findings showing that the dietary flavone glycoside was transformed into apigenin and linked to increased butyrate production. The research investigated how\u00a0apiin\u00a0influenced dextran\u00a0sulphate\u00a0sodium\u00a0(DSS)-induced colitis and\u00a0identified\u00a0gut microbial metabolism as a key factor in its protective effects.\u00a0<\/p>\n

Apiin\u00a0Transformation Supports Colitis Protection\u00a0<\/p>\n

Dietary glycosides are microbiota responsive food components with potential intestinal health benefits, although their mechanisms\u00a0remain\u00a0unclear.\u00a0Apiin, a naturally occurring flavone glycoside found in\u00a0plant-based\u00a0foods,\u00a0demonstrated\u00a0protective effects against colitis after undergoing microbial biotransformation in the distal intestine. The compound resisted host digestion but was efficiently converted by intestinal microbiota through\u00a0deglycosylation, producing apigenin, the bioactive aglycone.\u00a0<\/p>\n

Following\u00a0apiin\u00a0administration, researchers\u00a0observed\u00a0reduced colitis severity, with improvements in clinical and histopathological outcomes. The findings also showed lower production of pro-inflammatory cytokines, including TNF-\u03b1, IL-1\u03b2, IL-6, alongside restoration of intestinal barrier integrity.\u00a0<\/p>\n

These results suggested that\u00a0apiin\u00a0activity depended on interactions between dietary components and the gut microbiota, highlighting the importance of microbial metabolism in regulating intestinal inflammation.\u00a0<\/p>\n

Microbiota\u00a0and Butyrate Pathways Influence Colitis\u00a0<\/p>\n

Multi-omics analyses revealed that\u00a0apiin\u00a0reshaped gut microbiota composition and function, resulting in enhanced production of butyrate, a short-chain fatty acid associated with intestinal regulation. This metabolic change was linked to pathways involving G-protein coupled receptors and\u00a0PPAR\u03b3, as well as modulation of\u00a0NF-\u03baB-driven\u00a0inflammatory responses.\u00a0<\/p>\n

The findings\u00a0indicated\u00a0that\u00a0apiin\u00a0may influence colitis through a combination of microbial transformation and downstream metabolic signalling. The relationship between\u00a0apiin, microbiota activity, and butyrate production\u00a0provided\u00a0further insight into how dietary glycosides may affect inflammatory processes within the intestine.\u00a0<\/p>\n

Microbiota Transfer Confirms\u00a0Apiin\u00a0Effects\u00a0<\/p>\n

The role of the microbiota in\u00a0apiin\u00a0mediated colitis protection was further supported by faecal microbiota transplantation experiments. These experiments reproduced the protective effects\u00a0observed\u00a0after\u00a0apiin\u00a0administration, confirming that microbial communities contributed to the compound\u2019s activity.\u00a0<\/p>\n

Conclusion\u00a0<\/p>\n

Overall, the study\u00a0identified\u00a0apiin\u00a0as a microbiota-dependent pro-flavonoid with potential relevance for understanding mechanisms involved in colitis regulation. Its conversion into apigenin and association with butyrate related signalling pathways were linked to reduced inflammation and improved intestinal outcomes in experimental colitis.\u00a0<\/p>\n

Reference\u00a0<\/p>\n

Guo Z\u00a0et al.\u00a0Microbiota-dependent biotransformation of\u00a0apiin\u00a0drives butyrate-associated protection against colitis.\u202fnpj\u00a0Sci Food.\u00a02026;DOI:10.1038\/s41538-026-00992-4\u00a0<\/p>\n

Featured Image:\u00a0MithaArini\u00a0on Adobe Stock.\u00a0<\/p>\n","protected":false},"excerpt":{"rendered":"COLITIS\u00a0protection was associated with microbiota dependent\u00a0apiin\u00a0activity, with new findings showing that the dietary flavone glycoside was transformed into…\n","protected":false},"author":2,"featured_media":552221,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[7],"tags":[85,46,141],"class_list":["post-552220","post","type-post","status-publish","format-standard","has-post-thumbnail","category-science","tag-il","tag-israel","tag-science"],"_links":{"self":[{"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/posts\/552220","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/comments?post=552220"}],"version-history":[{"count":0,"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/posts\/552220\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/media\/552221"}],"wp:attachment":[{"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/media?parent=552220"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/categories?post=552220"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/tags?post=552220"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}