Pairwise, an agricultural technology company focused on CRISPR gene editing applications in plants, partners with organizations including Bayer, Corteva and Sun World to improve production efficiency in row crops and consumer-facing foods.\u00a0<\/p>\n
The vision is simple: use gene editing to solve practical problems faster than traditional breeding alone can.\u00a0<\/p>\n
\u201cTraditional breeding could potentially get us there one day, but it may take 50 years,\u201d says Bartlett. \u201cGene editing allows us to make meaningful improvements on a much faster timeline. And time is the limiting factor in everything we do as farmers.\u201d<\/p>\n
That accelerated timeline matters in agriculture, where producers face constant pressure to improve efficiency, sustainability and food quality.\u00a0<\/p>\n
One example is the seedless blackberry, which Pairwise helped develop after consumers repeatedly shared the same frustration: they loved the fruit\u2019s flavor and nutritional value but disliked the seeds.\u00a0<\/p>\n
\u201cConvenience drives consumption,\u201d says Bartlett. \u201cNow families can give their kids a nutritious choice without the nuisance of seeds.\u201d<\/p>\n
The same technology is also being used to address global food system challenges. Pairwise is also working to develop more compact yam varieties for use in African production systems, where improved efficiency could help address nutritional deficits in regions where yams are a staple. \u00a0\u00a0<\/p>\n
Transforming Human Healthcare Outcomes<\/p>\n
Outside of agriculture, gene editing is transforming human medicine.\u00a0<\/p>\n
\u201cIn the U.S., patients now have access to approved gene therapies that treat inherited diseases, including certain forms of blindness, hemophilia and several types of blood cancer,\u201d says Rachel Haurwitz, Ph.D., President and CEO of Caribou Biosciences. \u201cMore recently, we\u2019ve seen the first CRISPR-based gene-edited cell therapy approved for sickle cell anemia.\u201d<\/p>\n
Caribou Biosciences, Inc., founded by CRISPR pioneers including Nobel Prize winner Jennifer Doudna, is using gene editing technology to develop therapies for blood cancer.\u00a0<\/p>\n
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Photo credit: Getty Images\/daizuoxin; Canva Pro\/Zurijeta; Getty Images\/fcarucci; PIC<\/p>\n
Caribou\u2019s own gene-edited CAR-T cell therapies are showing promising results in patients who had exhausted other treatment options, with some patients remaining cancer-free years after a single treatment.<\/p>\n
For Haurwitz, those outcomes reinforce the broader potential of gene editing across industries.<\/p>\n
\u201cThis is not a single-use technology,\u201d she says. \u201cIt is a platform that can address challenges across human health, animal health, agriculture and many other fields.\u201d<\/p>\n
Tackling the Swine Industry\u2019s Challenge: PRRS<\/p>\n
For swine producers, one of those challenges is PRRS. Traditional biosecurity, vaccination and management strategies remain essential, but PRRS continues to pose a threat due to its ability to mutate and spread aggressively.<\/p>\n
Haurwitz sees PIC\u2019s work as an example of gene editing solving a highly targeted, real-world problem.\u00a0<\/p>\n
\u201cBy making a specific change to a gene involved in how the PRRS virus enters cells, PIC has created pigs that are resistant to the disease without introducing foreign DNA,\u201d she says. \u201cThat kind of precise, intentional change is exactly what makes CRISPR genome editing so powerful.\u201d<\/p>\n
Industry leaders believe gene editing will ultimately become another practical tool within agriculture \u2013 not a replacement for good management or breeding practices. In addition to solving operational problems for producers, gene editing represents an opportunity to meet consumer demands at the same time. The technology is a pathway for achieving reductions in antibiotic use, improved convenience, increased sustainability, enhanced nutrition and more \u2013 features that consumers are increasingly seeking out and endorsing with their purchase decisions.\u00a0<\/p>\n
With gene editing and gene therapies also leading to monumental solutions for devastating human diseases, consumers are growing increasingly familiar with gene editing and the benefits it can provide.\u00a0<\/p>\n
\u201cI think gene editing is going to become an integrated platform across all segments of agriculture,\u201d says Bartlett. \u201cIf we do this right, it\u2019s going to be pretty seamless.\u201d<\/p>\n
The future of gene editing does not represent a technological revolution, but rather a continuation of the promise producers have always made: adopting better tools to care for animals, improve productivity and build a more sustainable future. \u00a0<\/p>\n