{"id":609393,"date":"2026-09-08T07:50:23","date_gmt":"2026-09-08T07:50:23","guid":{"rendered":"https:\/\/www.newsbeep.com\/il\/609393\/"},"modified":"2026-09-08T07:50:23","modified_gmt":"2026-09-08T07:50:23","slug":"new-methods-to-contextualize-autism-linked-genes-and-more","status":"publish","type":"post","link":"https:\/\/www.newsbeep.com\/il\/609393\/","title":{"rendered":"New methods to contextualize autism-linked genes, and more"},"content":{"rendered":"<p>Group effect: Two new studies report on approaches to tackle a long-standing problem in autism research: There are many autism candidate genes\u2014often de-novo variants\u2014but any particular gene is rare in a population of autistic people. The first <a href=\"https:\/\/doi.org\/10.64898\/2026.08.22.746387\" target=\"_blank\" rel=\"nofollow noopener\">preprint<\/a> crunched data from past studies to create an atlas of organoid models and, with predictive modeling, explored how gene perturbations may affect developmental pathways. The technique may help prioritize those autism-linked gene candidates with functional, disease-relevant outcomes, the investigators wrote. The second <a href=\"https:\/\/doi.org\/10.64898\/2026.08.24.26360398\" target=\"_blank\" rel=\"nofollow noopener\">preprint<\/a> used data from gene-association studies to cluster autism-linked genes that contribute to other conditions, such as schizophrenia and epilepsy.\u00a0<\/p>\n<p>Autism research spotted this week:<\/p>\n<p>\u201cA high-resolution human pangenome structural variant resource for improved disease association\u201d <a href=\"https:\/\/doi.org\/10.64898\/2026.08.21.26361050\" target=\"_blank\" rel=\"nofollow noopener\">medRxiv<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"Group effect: Two new studies report on approaches to tackle a long-standing problem in autism research: There are&hellip;\n","protected":false},"author":2,"featured_media":609394,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[10],"tags":[163,85,46],"class_list":["post-609393","post","type-post","status-publish","format-standard","has-post-thumbnail","category-health","tag-health","tag-il","tag-israel"],"_links":{"self":[{"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/posts\/609393","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/comments?post=609393"}],"version-history":[{"count":0,"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/posts\/609393\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/media\/609394"}],"wp:attachment":[{"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/media?parent=609393"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/categories?post=609393"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/tags?post=609393"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}