{"id":615934,"date":"2026-09-14T16:28:12","date_gmt":"2026-09-14T16:28:12","guid":{"rendered":"https:\/\/www.newsbeep.com\/il\/615934\/"},"modified":"2026-09-14T16:28:12","modified_gmt":"2026-09-14T16:28:12","slug":"new-reference-material-could-make-angiotensin-ii-testing-more-comparable","status":"publish","type":"post","link":"https:\/\/www.newsbeep.com\/il\/615934\/","title":{"rendered":"New reference material could make angiotensin II testing more comparable"},"content":{"rendered":"

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\"Development<\/p>\n

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image:\u00a0<\/p>\n

Schematic overview of the development of the Angiotensin II certified reference material. The reference material was characterized using isotope dilution mass spectrometry and the mass balance method, with an assigned value of 0.8734 g\/g and a relative expanded uncertainty of 1.8% (k = 2). It remained stable for 12 months at \u221220 \u00b0C and is traceable to the SI unit of mass.<\/p>\n

view more\u00a0<\/a><\/p>\n

Credit: Yanjie Huang<\/p>\n

When two laboratories measure the same biomarker, how can they know that their results are truly comparable? For angiotensin \u2161\u00a0(Ang \u2161), this is an important practical question. Ang \u2161\u00a0is a small peptide hormone that plays a central role in regulating blood pressure and fluid-electrolyte balance and is also used as a biomarker in laboratory testing related to vascular disease. For results obtained by different laboratories or analytical methods to be meaningfully compared, measurements need to be linked to reliable reference standards.<\/p>\n

This need is particularly relevant because existing similar international Ang \u2161\u00a0reference materials can be difficult to access and may face supply limitations. In a new study published in Biomedical Analysis, researchers developed and characterized a candidate reference material for Ang \u2161\u00a0to provide an additional, well-characterized measurement benchmark. Reference materials function much like a common \u201cruler\u201d for laboratory measurement: they allow laboratories to validate analytical methods, evaluate measurement performance, and compare results across different measurement systems.<\/p>\n

To establish the new material, the researchers used two independent approaches\u2014isotope dilution mass spectrometry and the mass balance method\u2014to determine its purity. The methods rely on different measurement principles but produced closely consistent results, strengthening confidence in the assigned value. The material also showed excellent bottle-to-bottle homogeneity. The\u00a0overall relative expanded uncertainty of the assigned value was 1.8% (k=2).<\/p>\n

Importantly for practical use, the material remained stable for at least 12 months at \u221220\u00a0\u2103\u00a0and for at least seven days at both 4\u00a0\u2103\u00a0and 25\u00a0\u2103\u00a0under simulated transportation conditions. The researchers also verified their measurements against NRC ANG \u2161-1, a certified reference material from the National Research Council Canada. The comparison met the accepted equivalence criterion, providing additional support for the accuracy of the assigned value.<\/p>\n

The significance of the work extends beyond the characterization of a single reference material. By providing a common measurement benchmark, the material could support method validation, laboratory quality control, performance evaluation, and traceable measurement of Ang \u2161. In turn, this could help make Ang \u2161\u00a0results obtained using different methods and in different laboratories more comparable.<\/p>\n

The researchers caution that the study focused on the material’s metrological properties rather than its biological activity. Its biological activity has not yet been examined, and further studies will be needed to determine whether it retains equivalent activity in vivo. Within this scope, the new reference material provides an additional tool for strengthening the standardization and traceability of Ang II testing.<\/p>\n

DOI:\u00a010.1016\/j.bioana.2026.08.001<\/a><\/p>\n

Read the full article:\u00a0https:\/\/www.sciencedirect.com\/science\/article\/pii\/S2950435X26000272<\/p>\n

\u00a0<\/p>\n

Call for Papers<\/p>\n

Biomedical Analysis\u00a0invites submissions for its 2026 Special Issue.<\/p>\n

1. Biosensing and Nanoanalytical Technologies
Topics include advanced biosensing, nanoanalytical technologies, multimodal sensing, bioanalysis, and applications in disease diagnosis and precision medicine.
Submission deadline: September 30, 2026<\/p>\n

\u00a0View Special Issue :\u00a0https:\/\/www.sciencedirect.com\/special-issue\/334121\/biosensing-and-nanoanalytical-technologies<\/a><\/p>\n

2.POCT Technology Innovation and Application
Topics include novel POCT detection technologies, POCT materials and device development, multi-scenario applications, and intelligent and digital POCT.
Submission deadline: December 31, 2026.<\/p>\n

View Special Issue :\u00a0\u00a0https:\/\/www.sciencedirect.com\/special-issue\/10B8MK2ZDWC<\/a><\/p>\n

\u00a0<\/p>\n

About\u00a0Biomedical Analysis<\/p>\n

Biomedical Analysis\u00a0is an international, peer-reviewed, open access journal published by\u00a0KeAi and\u00a0Elsevier\u00a0and jointly sponsored by Sun Yat-sen University and the Guangzhou Analysis and Testing Center.<\/p>\n

The journal publishes high-quality research in biomedical engineering, bioanalytical chemistry, biochemistry, genetics, biology, biomaterials, medicine, and related interdisciplinary fields, with a particular focus on biomedical testing, sensing technologies, and analytical innovation.\u00a0Biomedical Analysis\u00a0is indexed in Scopus, CAS, DOAJ, and EBSCO.\u00a0Article processing charges (APCs) are currently waived for accepted manuscripts through the end of 2026.<\/p>\n

Journal website:\u00a0https:\/\/www.sciencedirect.com\/journal\/biomedical-analysis<\/a>.<\/p>\n

\u00a0<\/p>\n

Journal<\/p>\n

Biomedical Analysis<\/p>\n

Method of Research<\/p>\n

Experimental study<\/p>\n

Subject of Research<\/p>\n

Not applicable<\/p>\n

Article Title<\/p>\n

Development of a certified reference material for Angiotensin \u2161 with the mass balance method and isotope dilution mass spectrometry method<\/p>\n

Article Publication Date<\/p>\n

27-Aug-2026<\/p>\n

COI Statement<\/p>\n

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.<\/p>\n

Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.<\/p>\n","protected":false},"excerpt":{"rendered":"image:\u00a0 Schematic overview of the development of the Angiotensin II certified reference material. The reference material was characterized…\n","protected":false},"author":2,"featured_media":615935,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[6],"tags":[85,46,125],"class_list":["post-615934","post","type-post","status-publish","format-standard","has-post-thumbnail","category-technology","tag-il","tag-israel","tag-technology"],"_links":{"self":[{"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/posts\/615934","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/comments?post=615934"}],"version-history":[{"count":0,"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/posts\/615934\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/media\/615935"}],"wp:attachment":[{"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/media?parent=615934"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/categories?post=615934"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/tags?post=615934"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}