\n The future of boron neutron capture therapy depends on developing more selective and concentrated boron drugs.\n <\/p>\n
The future is brighter for patients with \u201cincurable\u201d cancers, such as end-stage head and neck cancers and invasive glioblastomas. Boron neutron capture therapy (BNCT) relies on the nuclear reaction between boron-10 and thermal neutrons to generate destructive alpha particles that travel only a cell\u2019s length, enabling tumor treatment while largely sparing adjacent healthy tissue.<\/p>\n
Xu et al. conducted a review of BNCT, including its physical principles, delivery agents, clinical outcomes, and future immunotherapies. They found that while the therapy\u2019s neutron sources are mature, its boron drugs currently present a bottleneck.<\/p>\n
\u201cBNCT is experiencing a true paradigm shift,\u201d said author Bing Yuan. \u201cWe are moving away from massive, expensive nuclear reactors to compact, hospital-friendly accelerator-based neutron sources, positioning BNCT to become a mainstream therapy.\u201d<\/p>\n
The researchers began by establishing the physical principles of the boron-neutron reaction and the crucial shift to accelerator-based neutron sources. They then categorized the evolution of boron drugs from simple molecules to peptide platforms and evaluated clinical outcomes from trials with head and neck cancers and glioblastomas. Finally, they discussed how BNCT could be combined with immunotherapy.<\/p>\n
The review revealed that boron delivery drugs must not simply achieve high boron concentrations in tumor cells, but also be present close to the nucleus. The review also showed how BNCT has high potential for priming the body for immunotherapy.<\/p>\n
Based on their findings, the researchers are now developing targeted boron delivery systems.<\/p>\n
\u201cBy perfecting BNCT, we are pushing the absolute boundaries of precision oncology,\u201d said Yuan. \u201cI feel a strong sense of responsibility and excitement to develop the \u2018smart software\u2019 that will unlock its full life-saving potential.\u201d<\/p>\n
Source: \u201cRecent advances and challenges in boron neutron capture therapy for cancer treatment,\u201d by Xiaoyan Xu, Yushuang Wei, Kai Yang, Jianqiang Liu, and Bing Yuan, Biophysics Reviews (2026). The article can be accessed at https:\/\/doi.org\/10.1063\/5.0342433 <\/a>.<\/p>\n","protected":false},"excerpt":{"rendered":"The future of boron neutron capture therapy depends on developing more selective and concentrated boron drugs. The future…\n","protected":false},"author":2,"featured_media":616507,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[7],"tags":[85,46,141],"class_list":["post-616506","post","type-post","status-publish","format-standard","has-post-thumbnail","category-science","tag-il","tag-israel","tag-science"],"_links":{"self":[{"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/posts\/616506","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/comments?post=616506"}],"version-history":[{"count":0,"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/posts\/616506\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/media\/616507"}],"wp:attachment":[{"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/media?parent=616506"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/categories?post=616506"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/tags?post=616506"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}