{"id":625766,"date":"2026-09-24T08:08:10","date_gmt":"2026-09-24T08:08:10","guid":{"rendered":"https:\/\/www.newsbeep.com\/il\/625766\/"},"modified":"2026-09-24T08:08:10","modified_gmt":"2026-09-24T08:08:10","slug":"tau-accumulation-reshapes-neurotransmitter-signaling-in-alzheimers-disease","status":"publish","type":"post","link":"https:\/\/www.newsbeep.com\/il\/625766\/","title":{"rendered":"Tau accumulation reshapes neurotransmitter signaling in Alzheimer\u2019s disease"},"content":{"rendered":"

In the U.S., 11% of people age 65 and older<\/a> have been diagnosed with Alzheimer\u2019s dementia. Alzheimer\u2019s disease, or AD, is characterized by the accumulation of two abnormal protein structures in the brain, amyloid-beta and misfolded tau protein. Neurotransmitters, the chemical messengers of neurons, are also dysregulated in AD, but it remains unclear whether there is a causal relationship between neurotransmitter imbalance and tau accumulation.<\/p>\n

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Scientific Animations via Wikimedia Commons<\/p>\n

Illustration of neurotransmitter signaling across synapses.<\/p>\n

To address this question, Eunji Cho, Seulah Lee and colleagues at the Korea Brain Research Institute conducted proteomics and neurotransmitter profiling in the brains of mice with AD in a study<\/a> recently published in Molecular & Cellular Proteomics. The researchers used a tauopathy mouse model, confirming age-dependent hyperphosphorylated tau aggregation.<\/p>\n

Proteomic analysis of seven brain regions at four and seven months of age revealed dysregulation of metabolic and cell cycle pathways, with increased signaling activation with age. Using high-performance liquid chromatography with electrochemical detection, the authors found that tauopathy mice had alterations in six neurotransmitters. Integrating these two datasets and validating them with gene and protein expression analyses, the researchers identified changes in dopamine- and serotonin-signaling molecules that correlated with neurotransmitter changes in some brain regions during AD progression.<\/p>\n

The authors concluded that tau accumulation may cause neurotransmitter remodeling and disrupt neuronal activity. Future studies incorporating transcriptomics and genomics may help identify new therapeutic targets for AD.<\/p>\n","protected":false},"excerpt":{"rendered":"In the U.S., 11% of people age 65 and older have been diagnosed with Alzheimer\u2019s dementia. Alzheimer\u2019s disease,…\n","protected":false},"author":2,"featured_media":625767,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[10],"tags":[163,85,46],"class_list":["post-625766","post","type-post","status-publish","format-standard","has-post-thumbnail","category-health","tag-health","tag-il","tag-israel"],"_links":{"self":[{"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/posts\/625766","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/comments?post=625766"}],"version-history":[{"count":0,"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/posts\/625766\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/media\/625767"}],"wp:attachment":[{"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/media?parent=625766"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/categories?post=625766"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/tags?post=625766"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}