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From left in the top row are Kim In-ki, a professor in Sungkyunkwan University\u2019s Department of Biophysics, and Ph.D. candidates Cho Han-jun and Kim Young-jun. From left in the bottom row are professor Park Jong-chan and master\u2019s student Yoon Na-hyun. Courtesy of Sungkyunkwan University<\/p>\n
Sungkyunkwan University researchers have developed a biochip technology that enables real-time monitoring of Parkinson\u2019s disease treatment responses.<\/p>\n
The university said Tuesday that the \u201corganoid-on-a-chip\u201d technology combines stem cell-derived \u201cmini-brains\u201d with a nanoplasmonic sensor that maximizes light-matter interactions, enabling real-time monitoring of treatment responses.<\/p>\n
The findings were published in ACS Nano, a leading international journal in nanoscience.<\/p>\n
The study was conducted by two research teams at the university, each led by Kim In-ki and Park Jong-chan, professors in the Department of Biophysics.<\/p>\n
The teams included Ph.D. candidates Cho Han-jun and Kim Young-jun and master\u2019s candidate Yoon Na-hyun, who were both first authors of the paper.<\/p>\n
\u201cThis study is significant in that it opens a path to continuously monitoring drug responses in living human tissue over time using an ultra-precision optical sensor,\u201d professor Kim said.<\/p>\n
\u201cWe will further develop the technology into a key platform for patient-specific drug development and disease treatment,\u201d he added.<\/p>\n
An organoid is a three-dimensional \u201cminiorgan\u201d grown from human stem cells to resemble an actual organ.<\/p>\n
The researchers created an organoid that mimics the brainstem, a key region that connects the brain and spinal cord and regulates vital functions such as breathing and movement.<\/p>\n
Parkinson\u2019s disease is a major neurodegenerative disorder in which dopamine-producing cells involved in controlling movement become damaged, causing symptoms such as tremors and muscle stiffness.<\/p>\n
In conventional drug development research, cells often had to be destroyed or specially stained to assess how a drug works.<\/p>\n
This made it difficult to continuously monitor when a drug begins to take effect and how long its effects last in living tissue.<\/p>\n
The research team addressed this limitation by harnessing a phenomenon known as optical resonance, which occurs when light interacts with gold nanostructures much smaller than the width of a human hair.<\/p>\n
The researchers attached an artificial DNA molecule called an aptamer, which specifically responds to dopamine, to a sensor surface combining gold nanoholes with a vertical optical resonator.<\/p>\n
This enabled the researchers to detect the amount of dopamine released from the brainstem organoids with ultrahigh sensitivity without damaging the tissue.<\/p>\n
The researchers monitored the response of Parkinson\u2019s disease brainstem organoids in real time for 12 hours using a microfluidic chip that precisely delivers culture media and drugs through tiny channels.<\/p>\n
The study showed that increasing the drug concentration does not necessarily lead to greater therapeutic effects.<\/p>\n
Based on these findings, the researchers identified an optimal dosage that showed the most favorable therapeutic response for patients.<\/p>\n
The findings demonstrate that the platform can accurately measure over time when a drug begins to take effect, when it reaches its maximum effect and how long the effect lasts in a model that mimics human brain tissue.<\/p>\n
The technology is expected to help shorten drug development timelines and reduce costs by narrowing the gap between animal studies and human clinical trials.<\/p>\n","protected":false},"excerpt":{"rendered":"From left in the top row are Kim In-ki, a professor in Sungkyunkwan University\u2019s Department of Biophysics, and…\n","protected":false},"author":2,"featured_media":628953,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[10],"tags":[163,85,46],"class_list":["post-628952","post","type-post","status-publish","format-standard","has-post-thumbnail","category-health","tag-health","tag-il","tag-israel"],"_links":{"self":[{"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/posts\/628952","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/comments?post=628952"}],"version-history":[{"count":0,"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/posts\/628952\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/media\/628953"}],"wp:attachment":[{"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/media?parent=628952"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/categories?post=628952"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/tags?post=628952"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}