{"id":634218,"date":"2026-10-02T13:04:11","date_gmt":"2026-10-02T13:04:11","guid":{"rendered":"https:\/\/www.newsbeep.com\/il\/634218\/"},"modified":"2026-10-02T13:04:11","modified_gmt":"2026-10-02T13:04:11","slug":"are-anti-seizure-medications-linked-to-neuropsychiatric-events","status":"publish","type":"post","link":"https:\/\/www.newsbeep.com\/il\/634218\/","title":{"rendered":"Are Anti-Seizure Medications Linked to Neuropsychiatric Events?"},"content":{"rendered":"

In a review published in the journal\u00a0Epilepsy Research<\/a>,\u00a0Kunal Kumar, of Delhi Pharmaceutical Science and Research University in New Delhi, India, and colleagues analyzed observational evidence on the link between first-, second-, and third-generation ASM use and NPAEs in patients with epilepsy. Included studies (n=18) were identified through searches of MEDLINE, Embase, and PsycInfo from inception to May 2026 and included 5,151,367 patients.<\/p>\n

Primary outcomes included incidence of behavioral, cognitive, mood, sleep, and psychotic disorders during treatment with an ASM. Results showed that memory disorders were reported in 8.7%, 3.8%, and 6.2% of participants treated with first-, second-, and third-generation ASMs, and depression was reported in 2.3%, 1.2%, and 3.0% of patients in these groups.<\/p>\n

Difference in psychosis risk was not statistically significant between first- and second-generation ASMs (relative risk, 0.77; 95% CI, 0.34-1.76). However, second-generation ASMs had a lower point estimate for psychotic disorders compared with third-generation ASMs, although the authors warn that this finding should be interpreted with caution because it was borderline and imprecise.<\/p>\n

When evaluating the association between NPAEs and specific ASMs, the researchers found that topiramate was linked with the greatest risk for psychosis (odds ratio, 3.07; 95% CI, 2.55-3.71), and levetiracetam was linked with substantially higher odds of suicidality in one study.<\/p>\n

Overall, the results suggest that ASM use is linked with various NPAEs, with risk varying by ASM type. The authors note that these findings support consideration of NPAEs in selection of ASMs, along with routine monitoring for NPAEs in patients treated with ASMs, particularly those with preexisting psychiatric comorbidities.<\/p>\n

However, they also add that because the included studies are observational and highly heterogeneous, large-scale prospective studies are still needed to clarify the risks for NPAEs in patients treated with ASMs.<\/p>\n","protected":false},"excerpt":{"rendered":"In a review published in the journal\u00a0Epilepsy Research,\u00a0Kunal Kumar, of Delhi Pharmaceutical Science and Research University in New…\n","protected":false},"author":2,"featured_media":634219,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[10],"tags":[163,85,46],"class_list":["post-634218","post","type-post","status-publish","format-standard","has-post-thumbnail","category-health","tag-health","tag-il","tag-israel"],"_links":{"self":[{"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/posts\/634218","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/comments?post=634218"}],"version-history":[{"count":0,"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/posts\/634218\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/media\/634219"}],"wp:attachment":[{"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/media?parent=634218"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/categories?post=634218"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/tags?post=634218"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}