{"id":640245,"date":"2026-10-08T14:38:13","date_gmt":"2026-10-08T14:38:13","guid":{"rendered":"https:\/\/www.newsbeep.com\/il\/640245\/"},"modified":"2026-10-08T14:38:13","modified_gmt":"2026-10-08T14:38:13","slug":"beyond-amyloid-and-tau-blood-testing-for-neurodegenerative-and-psychiatric-disease","status":"publish","type":"post","link":"https:\/\/www.newsbeep.com\/il\/640245\/","title":{"rendered":"Beyond Amyloid and Tau: Blood Testing for Neurodegenerative and Psychiatric Disease"},"content":{"rendered":"\n<p class=\"\">Blood-based diagnostics for Alzheimer disease have advanced in recent years, with the US Food and Drug Administration clearing a test and multiple companies developing assays based on amyloid plaques or phosphorylated tau.1 Now, Navneet Dogra, PhD, and colleagues are pursuing a different target: the RNA trajectory from DNA to protein. Dogra\u2019s work hypothesized that RNA changes might precede pathology, allowing detection of dementia 1 step ahead of the pathology occurring.<\/p>\n<p class=\"\">The strategy began with a blood draw, followed by isolation of extracellular vesicles and particles (EVPs), and then RNA extraction.2 Dogra said he ultimately aimed to develop a polymerase chain reaction (PCR) assay targeting a defined set of RNAs that changed consistently with aging, neurodegeneration, or Alzheimer disease. These test types are familiar, with PCR tests being widely used during COVID-19. In principle, the full process from blood sample to result could take 4 to 5 hours. Dogra described the concept as &#8220;taking someone&#8217;s blood, extracting a set of extracellular vesicles and particles, and then looking at their RNA and understanding what is going on in the brain.&#8221;<\/p>\n","protected":false},"excerpt":{"rendered":"Blood-based diagnostics for Alzheimer disease have advanced in recent years, with the US Food and Drug Administration clearing&hellip;\n","protected":false},"author":2,"featured_media":640246,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[10],"tags":[163,85,46],"class_list":["post-640245","post","type-post","status-publish","format-standard","has-post-thumbnail","category-health","tag-health","tag-il","tag-israel"],"_links":{"self":[{"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/posts\/640245","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/comments?post=640245"}],"version-history":[{"count":0,"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/posts\/640245\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/media\/640246"}],"wp:attachment":[{"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/media?parent=640245"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/categories?post=640245"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/tags?post=640245"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}