Khodab is an incoming resident specializing in radiation oncology at University of Miami Sylvester Cancer Center.<\/p>\n
Transcript:<\/p>\n
CancerNetwork: Going in, was the hypothesis that larger prostates would predict worse urinary quality of life after radiation? How do the actual results compare to what you expected?<\/p>\n
Khodab: The initial hypothesis was that we figured that the IPSS scores would be higher for the larger prostate group, which made sense because of the mechanical obstruction aspect. But we didn\u2019t think that the IPSS scores would respond as much because the other factor is that, for larger prostates, there\u2019s more dose delivered to the surrounding structures\u2014the lower urethra and the trigone of the bladder. We didn\u2019t really expect the IPSS scores to decrease as substantially as they did, but they normalize to about the level that we found in the normal-size cohort.<\/p>\n
Some of the limitations: this study ran from 2004 to 2019, and prostate cancer treatment has evolved so much over that time. Although all patients were treated with external beam [radiation] without any brachytherapy, treatment modalities have changed, technology has changed, and there were different radiation oncologists doing the plans, which are variables we can\u2019t really control for in a retrospective study. In a prospective study, we could control for a lot more of these variables and be more consistent, but that\u2019s a natural limitation of the study design we chose, and it\u2019s also what allowed us to have as large a cohort as we did.<\/p>\n
Reference<\/p>\n
Khodab A, Kacker S, Song D, et al. Determining the effect of prostate size on the quality-of-life outcomes for prostate cancer patients undergoing definitive radiotherapy. Presented at: 2026 American Society for Radiation Oncology (ASTRO) Annual Meeting; October 2026. Abstract 3294<\/p>\n","protected":false},"excerpt":{"rendered":"Khodab is an incoming resident specializing in radiation oncology at University of Miami Sylvester Cancer Center. Transcript: CancerNetwork:…\n","protected":false},"author":2,"featured_media":641612,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[10],"tags":[163,85,46],"class_list":["post-641611","post","type-post","status-publish","format-standard","has-post-thumbnail","category-health","tag-health","tag-il","tag-israel"],"_links":{"self":[{"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/posts\/641611","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/comments?post=641611"}],"version-history":[{"count":0,"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/posts\/641611\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/media\/641612"}],"wp:attachment":[{"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/media?parent=641611"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/categories?post=641611"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/tags?post=641611"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}