Researchers enrolled participants aged 18-70 years with newly diagnosed type 2 diabetes and obesity, and participants were randomised to either a high-fibre dietary intervention or metformin monotherapy.\u00a0<\/p>\n
The high-fibre group received two standardised fibre formulations and dietary guidance but no glucose-lowering medication. The metformin group received metformin according to routine clinical practice.\u00a0\u00a0<\/p>\n
Primary clinical outcomes were HbA1c and BMI\u202fand secondary clinical outcomes included fasting blood glucose, glycated serum protein and glucose responses during the meal tolerance test (MTT).\u00a0<\/p>\n
Participants recorded types and amounts of foods consumed using a food frequency questionnaire and 24-h dietary recalls.\u202f\u00a0<\/p>\n
High-Fiber Diet Outperforms Metformin\u00a0<\/p>\n
High-fibre diet achieved significantly better glycemic control and weight-related outcomes than those receiving metformin alone and had a lower adjusted HbA1c at the end of the study and a lower adjusted BMI.\u00a0<\/p>\n
Continuous glucose monitoring showed that high-fiber participants had significantly better glucose stability. Compared with the metformin group, participants in the high-fibre group had lower mean blood glucose levels, lower glucose coefficient of variation, and lower standard deviation of glucose.\u00a0<\/p>\n
Participants in the high-fibre group had significantly lower waist-to-hip ratios, as well as lower leg fat mass, trunk fat mass, and total body fat mass. Serum triglyceride levels were also significantly lower than in the metformin group.\u00a0<\/p>\n
Overall microbial community structure differed significantly from baseline and from that seen in the metformin group. Several bacterial species associated with carbohydrate fermentation increased during the high-fibre intervention.\u00a0<\/p>\n
Researchers found that participants whose acetate levels increased experienced significantly greater reductions in HbA1c at Days 28 and 56 and had distinct baseline microbiome characteristics.\u00a0<\/p>\n
Clinical Implications of High-fibre dietary intervention\u00a0<\/p>\n
Researchers concluded that a high-fibre dietary intervention may offer a promising strategy for managing newly diagnosed diabesity, delivering greater improvements in blood sugar control and body weight than metformin alone. Future studies involving larger patient populations and longer follow-up periods could help clarify the durability of these benefits and their underlying microbiome-related mechanisms.\u00a0<\/p>\n
Reference<\/p>\n
Li Y et al. High-fiber diet altered gut microbiota, improved glycemic control, and reduced body weight in newly diagnosed type 2 diabetes and obesity. Front Cell Infect Microbiol.2026. DOI; 10.3389\/fmicb.2026.1972983.\u00a0<\/p>\n","protected":false},"excerpt":{"rendered":"Researchers enrolled participants aged 18-70 years with newly diagnosed type 2 diabetes and obesity, and participants were randomised…\n","protected":false},"author":2,"featured_media":645240,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[10],"tags":[163,85,46],"class_list":["post-645239","post","type-post","status-publish","format-standard","has-post-thumbnail","category-health","tag-health","tag-il","tag-israel"],"_links":{"self":[{"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/posts\/645239","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/comments?post=645239"}],"version-history":[{"count":0,"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/posts\/645239\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/media\/645240"}],"wp:attachment":[{"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/media?parent=645239"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/categories?post=645239"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.newsbeep.com\/il\/wp-json\/wp\/v2\/tags?post=645239"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}