GLP-1 medications like semaglutide and tirzepatide can lead to significant weight loss and may help reduce inflammation, improve mobility, and quiet persistent thoughts about food. Many people report life changing results after years of unsuccessful diets.A Healthline story on Mayim Bialik\u2019s GLP-1 side effects became our most engaged Facebook post of the year, as thousands of commenters shared hard side effects and life changing results. Research also increasingly links GLP-1s to benefits beyond weight loss.Healthline\u2019s Editor-in-Chief Robin Hough talks with his mom, Catherine, who lost 56 pounds on tirzepatide, and a registered nurse who has lost over 50 pounds, about the benefits, side effects, and cost of long-term treatment.<\/p>\n
\u201cYears of diets that worked for a couple of months, then gave all the weight back and more. Now the food noise has gone quiet,\u201d a GLP-1 user shared. <\/p>\n
In June, our brilliant News team published a piece about actor Mayim Bialik and her challenging experience<\/a> with GLP-1 side effects. It did well, like many of the celebrity + health condition + human-interest angle features we create tend to do with our audience (that\u2019s you all reading this!). Not a massive viral hit by any measure, but a strong performer on the traffic front.<\/p>\n Life in a busy newsroom went on. <\/p>\n Jump forward nearly 4 months; our equally brilliant social media team posts the piece on Facebook<\/a>, leading with one of Bialik\u2019s quotes from the article: \u201cGLP-1s have helped people in serious need. Of that I am certain. But nobody talks much about what happens when it goes wrong.\u201d <\/p>\n The fuse was lit. Nearly 12k likes, 1k reposts, and 3.5k comments later, the team had their most engaged post of the year by some margin. The irony is not lost on me that Bialik\u2019s quote, about how rarely people talk about side effects, sparked such a deep conversation about that very thing. <\/p>\n GLP-1s are a big topic for Healthline. They drive traffic, they drive revenue, and they offer a rich seam of human-centric storytelling<\/a> for our teams. Even so, no one predicted the post would catch fire the way it did. Our social team\u2019s read is that a few things stacked up: Mayim Bialik is a name our Facebook audience knows, the topic is one where nearly everyone has a stake, and a busy thread tends to get shown to more people, who then add more comments. That\u2019s the hypothesis. What we\u2019ve consistently seen is that posts that lead with a quote get more people talking than those that lead with a headline. You may have noticed this article takes the same approach.<\/p>\n We also know that the comment sections on social media aren\u2019t always the most hospitable of environments, particularly in the health space. What stood out about the lion\u2019s share of the comments we read was how constructive the discourse was. People were leading with deeply personal and often moving perspectives about the life changing impact (for good and bad) of GLP-1s. In turn, they were met with equally balanced and thoughtful responses. <\/p>\n Many of the comments expanded on Bialik\u2019s experience, detailing long and difficult battles with a range of side effects<\/a>. But plenty told the other side of the story: years of failed diets and struggles with chronic conditions leading to despondency, side effects that went on to ease with time, and life changing results that were ultimately worth the cost.<\/p>\n The line that opened this piece could have come from any of those commenters. It didn\u2019t. It came from Catherine Hough, who is 75 and lives in London. Eagle-eyed readers will have spotted that she has the same surname as me \u2013 that\u2019s because she\u2019s my mom. She\u2019s one of two people closer to the Healthline home who spoke to me for this piece and whose stories echo the Facebook post thread, with the good and the hard bits side by side.<\/p>\n Catherine was a hockey player and distance runner as a girl, the kind who could eat what she liked without it showing. Then came children, and a weight that crept up year after year, with decades of diets that \u201cworked for a couple of months only to be back to my former weight and then some.\u201d In late 2024, after a lot of research, she decided to try tirzepatide<\/a>.<\/p>\n Since then, Catherine has lost 56 pounds. She says her joints hurt less, which she puts down to reduced inflammation. She is more mobile. The constant chatter about food has faded. She thinks harder before she eats now. <\/p>\n \u201cI am a strong believer that obesity is a disease and in my case certainly not the result of overindulgence or laziness,\u201d she says. \u201cGLP-1s have greatly improved my health and self-esteem. After years of struggling with my weight, I have finally found a way to solve the problem.\u201d<\/p>\n Catherine will also tell you what it cost. Nausea. Constipation. Sulfur-tasting burps and rough nights of indigestion. Initial hair loss that has since grown back, and loose skin. Muscle loss. And she misses some of the true joy of cooking and eating food. <\/p>\n But despite bumps in her journey, Catherine remains convinced that the benefits of GLP-1s for her life and health outweigh any drawbacks she\u2019s experienced. \u201cI am conscious that I will probably be on this drug for a long time if not for life. It is truly a miracle drug.\u201d <\/p>\n I also spoke to Ann Marie Maguire, AGNP-C, RN, TCTCN, a nurse practitioner specializing in transplantation and cellular therapy, the sister of Healthline\u2019s Chief Business Officer Christine Macguire, and someone who has lost over 50lbs since starting GLP-1s in 2022. <\/p>\n \u201cI struggled with my weight since my teens and always believed I should be able to manage it on my own. But in my 30s, my knees were hurting just getting out of bed or walking to dinner. I realized how much my weight was affecting my quality of life. Starting a GLP-1 in 2022, alongside healthier eating and exercise, made a tremendous difference. My only regret is not starting sooner,\u201d said Ann Marie. <\/p>\n As a healthcare professional, Ann Marie also identified cost<\/a> as a major factor that can\u2019t be ignored regarding GLP-1s and their impact. <\/p>\n \u201cThere\u2019s understandable debate about the long-term use and cost of these medications,\u201d she says. \u201cBut we also need to consider the health and financial burden of obesity, including cardiovascular complications, hospitalizations, surgeries and ongoing medications. The cost conversation should account for the potential benefits of preventing or reducing those complications.\u201d<\/p>\n Ann Marie points to a frustration many patients will recognize: reaching a healthier weight can become the reason coverage gets cut off. \u201cWe don\u2019t automatically stop blood pressure medication because a patient\u2019s readings improve,\u201d she says. The treatment may be what\u2019s keeping the condition controlled. Obesity, she argues, deserves the same approach. \u201cReaching a goal weight can mean treatment is working, and decisions about continuing it should reflect the patient\u2019s ongoing needs, benefits and side effects.\u201d<\/p>\n It\u2019s important to note that this article looks at the experiences of only a handful of people out of the millions<\/a> who now take GLP-1s. Like all drugs, these medications are not right for everyone. Side effects are common; some of them can be serious, and both the long-term impact and what happens when people stop are still being worked out. Ultimately, your care team, with knowledge of your medical history, is a far better guide than a comment thread.<\/p>\n Yet the evidence now reaches well beyond the scales: large trials<\/a> have linked semaglutide<\/a> to fewer heart attacks and strokes in people with heart disease and slower kidney decline in people with diabetes and kidney disease, and tirzepatide became the first FDA-approved drug<\/a> for moderate to severe sleep apnea in adults with obesity.<\/p>\n Stories like Catherine\u2019s, Ann Marie\u2019s, Mayim Bialik\u2019s, and those of the 3.5k commenters on the Facebook post aren\u2019t proof of what will happen to you one way or another. But for a lot of people, my mom included, these drugs have changed what an ordinary day looks like, and in many cases changed what their future can look like. <\/p>\n One of the most significant drug developments of the century so far? Hard to argue with. <\/p>\n