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\n A new study found the most commonly prescribed antidepressants in the U.S., called Selective Serotonin Reuptake Inhibitors, or SSRIs, tended to have fewer side effects than some older medications.<\/p>\n
Guido Mieth\/Moment RF\/Getty Images<\/p>\n
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Guido Mieth\/Moment RF\/Getty Images<\/p>\n
Doctors have long known that antidepressants come with side effects for cardiovascular and metabolic health.<\/p>\n
But a major analysis from a team of researchers in the U.K. has, for the first time, pulled together data from more than 150 clinical trials to compare the physical side effects of dozens of antidepressants.<\/p>\n
The study, published in the Lancet<\/a> this week, details how each medication can affect weight, blood pressure, heart rate, cholesterol and other areas of health.<\/p>\n The end result is something akin to a “sports league table” for 30 different antidepressants based on their side effect profile, says lead author Dr. Toby Pillinger<\/a>, a psychiatrist at King’s College London.<\/p>\n “It’s never been done at this scale before and no one’s ever put specific numbers to the amount of weight you’ll put on, or to the amount that your cholesterol goes up,” he says.<\/p>\n The findings are based on existing data, mostly from 8-week drug studies, that altogether represent more than 58,000 patients.<\/p>\n The most frequently prescribed antidepressants in the U.S. \u2014 Selective Serotonin Reuptake Inhibitors<\/a>, or SSRIs, like Zoloft and Prozac <\/a>\u2014 tended to have fewer physical side effects, according to the analysis.<\/p>\n Other medications, particularly some of the older drugs, were shown to have more significant impacts.<\/p>\n For example, a person who took nortriptyline, a tricyclic antidepressant<\/a>, could, on average, have an increase in heart rate that was 20 beats higher than the SSRI fluvoxamine. For other medications, the expected weight change could be four pounds gained, or lost.<\/p>\n Pillinger says the intention is not to single out certain antidepressants as better than others.<\/p>\n “It may be that one medication which is pretty bad for one person actually is pretty good for another one. I think that is the message, rather than naming and shaming certain drugs,” he says.<\/p>\n Pillinger hopes the data can help prescribers and their patients make individualized decisions about the best medication.<\/p>\n In fact, he and his colleagues have created a free digital tool <\/a>that’s already being used by clinicians all over the world to create a “menu” of options, based on a patient’s underlying health and what side effects they’d most like to avoid.<\/p>\n Dr. Nina Kraguljac<\/a>, a professor at the Ohio State University, who was not involved in the research, says the study was well-done \u2014 and largely reassuring.<\/p>\n “What surprised me about this study is that side effects are not that severe,” says Kraguljac, who is also chair of the American Psychiatric Association’s council on research.<\/p>\n However, she stresses that “side effects alone should not guide a clinical decision,” since the study’s results ultimately reflect an average, not the individual patient.<\/p>\n “Side effects do not happen in every patient and are not necessarily a reason to deter people from taking the medications,” she says.<\/p>\n The study does have some notable limitations.<\/p>\n Even though many people take these drugs for months or years, the data was largely from 8-week randomized controlled trials, which are the most common.<\/p>\n And some prominent side effects \u2014 that cause some people to stop taking antidepressants \u2014 were not evaluated, says Dr. David Hellerstein<\/a>, a professor of psychiatry at Columbia University.<\/p>\n He points out the impact on sexual function, gastrointestinal issues, and “emotional blunting” \u2014 a sense that feelings are being muted \u2014 are all common complaints that weren’t looked at.<\/p>\n![\"With](\"https:\/\/npr.brightspotcdn.com\/dims3\/default\/strip\/false\/crop\/2160x2160+840+0\/resize\/100\/quality\/100\/format\/jpeg\/?url=http%3A%2F%2Fnpr-brightspot.s3.amazonaws.com%2F24%2Fab%2Fb29fb4154393bb4d06b197b69df7%2Faitherapist5.jpg\")
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