Zwitterionic lipid design enhances mRNA cancer vaccine efficacy and reduces reactogenicity

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This is a summary of: Zhao, Y. et al. Low reactogenicity and high tumour antigen expression from mRNA-LNPs with membrane-destabilizing zwitterionic lipids. Nat. Biomed. Eng. https://doi.org/10.1038/s41551-025-01577-4 (2025).