Airport traffic was backed up by a two-vehicle crash which closed a lane of State Highway 1 near Mosgiel.
Police received a report of the crash at the intersection of Main South Road/SH1 and Gladfield Road about 10.50am on Tuesday morning.
There were no reports of injuries and traffic was down to one lane.
Motorists are advised to avoid the area and expect delays, police said.
The road reopened at around 11.50am.