A major CBD thoroughfare has been closed following a suspected mental health incident near a popular sports bar on Sunday afternoon.

At least six police cars, two ambulances and an MFS vehicle shut down two lanes outside the Legends Sports Bar on Pulteney St between Rundle St and North Tce after 2.30pm.

Police would not confirm the nature of the incident but it is understood it is related to mental health.

Emergency services were focused on an area outside Adelaide Mansions apartments and Legends Sports Bar.