“Sadly, one person was pronounced deceased at the scene,” Bowman said.
Hato Hone St John responded with two ambulances.
Crews assessed four people, all in a moderate condition.
Three people were treated at the scene, while the fourth was taken to Southland Hospital.
Leet St in Invercargill is expected to be closed for much of today.
In a separate incident, one person died following a single-vehicle crash on the rural road, Winding Creek Rd, north of Gore, at about 12.40am today.
Police confirmed one other person sustained moderate injuries and was seen by ambulance services.
Hato Hone St John sent a first response unit, an ambulance, a rapid response unit and a helicopter to the scene.
One person was airlifted to Dunedin Hospital in a serious condition.
St John referred inquiries to police for further information on the crash.
Motorists are advised to avoid the road or delay travel while emergency services work at the scene.
The road is expected to remain blocked for most of the day.
Diversions are in place while emergency services work at the scene, and motorists should allow extra time for travel.
The Serious Crash Unit has been advised of both crashes.
Meanwhile, police are seeking CCTV and witnesses to the crash on Leet St.
Police continue to investigate the matter and are seeking the public’s assistance.
“The matter will also be referred to the IPCA, as is standard procedure in cases like this,” he said.
If anyone has witnessed the crash, or holds CCTV in the areas of Wellesley Avenue, Avenal Street or Kelvin Street, they are advised to contact police.
Reports can be made online on 105 using the reference number: 260322/6911.
Information can also be provided anonymously through Crime Stoppers on 0800 555 111.