A musical exploring the global threat of antibiotic resistance has made its London premiere, featuring a chorus of 60 NHS healthcare workers.

Lifeline follows the story of Sir Alexander Fleming’s discovery of penicillin at St Mary’s Hospital in Paddington in 1928, weaving his historical journey with a contemporary narrative centred on a junior doctor in Edinburgh.

The production aims to highlight the urgent reality of antimicrobial resistance (AMR), a crisis Fleming himself warned of decades ago.

Prof Ashley Brown, a consultant at St Mary’s who has worked at the institution for 25 years, said “singing is good for the heart”.