Oxford Health Charity, part of the trust, is delivering a series of events that aim to share the experiences of patients, staff, and the wider community over two centuries of hospital care.
The project, which received a grant of £156,258 from the National Lottery Heritage Fund, also aims to inform people about the site and get people talking about mental health.
The Warneford Hospital was pioneering for its time, built with just 40 beds, in contrast to inner city asylums which would have up to 2,000.
Dr Marlowe described its status as the oldest continuously used NHS facility as “quite remarkable”.
“This year we are marking the patients, carers, families, and staff across disciplines who have become part of the hospital’s 200-year history,” he said.
“The natural landscape offered by the hospital was very much part of the moral therapy offered to patients and is something that is just as important today as it was 200 years ago.”
He said its history reflected “wider shifts in medicine, society, and attitudes toward mental health”.
“Marking its bicentenary has meant thinking carefully about what should be preserved, what should be questioned, and how we honour the people who lived, worked, and were cared for there,” he added.