Chronic inflammation shapes cancer progression and immunotherapy response
Chronic inflammation is both a driver and suppressor of cancer depending on context. Key players-NF-κB, IL-6, STAT3, TAMs,…
Nasal COVID vaccine boost increases IgA responses linked to variant neutralisation
A novel nasal booster approach may help close the gap between systemic vaccination and infection-blocking mucosal immunity, offering…
Antibody feedback reshapes B cell selection during immune response
A collaborative study published in Immunity from the Batista Lab and Liu Lab at the Ragon Institute, together…
Alzheimer’s plaques decline after CAR-T immune cell treatment in preclinical study
A novel CAR-T cell approach targets amyloid plaques in preclinical Alzheimer models, raising the possibility that engineered immune…
Breakthrough nasal spray found to protect against all forms of flu
Scientists have developed a nasal spray that is safe and effective in protecting against various strains of the…
Targeted fab fragments dismantle the allergy trigger
Allergic diseases represent a major global health burden, placing significant strain on healthcare systems worldwide. Severe conditions such…
Customizable protein platforms offer new hope for cancer treatment
Precise methods for shredding or repairing and replacing specific cancer-causing proteins in a malignant cell, developed at the…
Researchers discover how Mycoplasma pneumoniae acquires cholesterol from human hosts
A multidisciplinary team has uncovered a key mechanism that allows the human bacterium Mycoplasma pneumoniae-responsible for atypical pneumonia…
Epigenetic plasticity in germinal center B cells may help explain lymphoma origins
Immune cells called B cells make antibodies that fight off invading bacteria, viruses and other foreign substances. During…
Dinutuximab beta plus chemotherapy shrinks neuroblastoma tumors in children
Children with a rare form of cancer called neuroblastoma which hasn’t responded to initial treatment or that has…
Novel antibody suppresses primary tumor growth and spread of triple-negative breast cancer
Triple-negative breast cancer (TNBC) is one of the most aggressive and treatment-resistant forms of breast cancer. It grows…
Calcium-activated switch improves delivery and potency of cancer-fighting drugs
Cancer-fighting antibody drugs are designed to penetrate tumor cells and release a lethal payload deep within, but too…