Advances in chemistry and delivery are taking oligonucleotide medicines beyond rare diseases
Decades of work on RNA targeting, chemical modification, and tissue-specific delivery are reshaping what programmable genetic medicines can…
APOE genotype helps p-tau217 predict who may develop cognitive impairment sooner
A pooled analysis across seven multiethnic cohorts examines whether the same p-tau217 reading carries the same prognostic meaning…
Scientists traced a hidden immune route that may worsen tau-linked brain damage
Researchers traced an immune pathway from brain-draining lymph nodes to tau-affected tissue, revealing how peripheral immune activity may…
Simple blood test maps hidden Alzheimer’s disease changes
A large community study shows that Alzheimer’s-related brain changes are far more widespread with age than symptoms alone…
Switching APOE4 to APOE2 in adult mice reduces Alzheimer’s pathology and improves memory
By flipping a single genetic switch from APOE4 to APOE2 in adult mice, researchers reversed key Alzheimer’s-like changes…