COMP promotes the progression of colorectal cancer by regulating epithelial mesenchymal transition | BMC Cancer
Enrichment of EMT in CRC Analysis of gene expression data from the GSE39582 and TCGA datasets revealed that…
A full life cycle biological clock based on routine clinical data and its impact in health and diseases
Study populations The China Health Aging Investigation (CHAI), as a project of the International Consortium of Digital Twin…
Pre-pandemic disease trajectories and genetic insights into long COVID susceptibility | BMC Medicine
Study population This study utilises data from COVICAT, an adult COVID-19 population-based cohort in Catalonia [2, 10, 11],…
Development and external validation of a FISH-clinical nomogram for predicting overall survival in bladder cancer patients after radical cystectomy | BMC Cancer
Siegel RL, Miller KD, Wagle NS, Jemal A. Cancer statistics, 2023. CA Cancer J Clin. 2023;73(1):17–48. PubMed Google…
The MyCancerGene study: a hybrid type 1 effectiveness-implementation randomized study comparing a patient-centered digital genetic health portal to usual care after receipt of cancer genetic testing | BMC Cancer
Robson ME, Storm CD, Weitzel J, Wollins DS, Offit K. American society of clinical oncology policy statement update:…
Pathogenic UNC13A variants cause a neurodevelopmental syndrome by impairing synaptic function
Institute of Medical Genetics, University of Zurich, Zurich, Switzerland Reza Asadollahi, Paranchai Boonsawat, Dennis Kraemer & Anita Rauch Faculty of Engineering and…
Modeling heterogeneity in single-cell perturbation states enhances detection of response eQTLs
Cohorts We used published data (GEO accession no. GSE162632) to study the effect of 12 h of ex vivo…
Twenty years of genome-wide association studies: Health translation challenges and AI opportunities
Southam L, Zeggini E. Twenty years of genome-wide association studies. Nature. 2025;641:47–9. Article PubMed CAS Google Scholar Klein…
Association of genetic variants in m1A modification core genes and neuroblastoma risk | BMC Cancer
Park JR, Kreissman SG, London WB, Naranjo A, Cohn SL, Hogarty MD, et al. Effect of tandem autologous…
Redefining cellular reprogramming with advanced genomic technologies
Briggs, R. & King, T. J. Transplantation of living nuclei from blastula cells into enucleated Frogs’ eggs. Proc.…
Curcumin in prostate cancer: a systematic review of molecular mechanisms and nanoformulated therapeutic strategies | BMC Cancer
Curcumin, a dietary polyphenol derived from Curcuma longa, has been extensively studied for its pleiotropic biological activities, particularly…
Characterization of induced cohesin loop extrusion trajectories in living cells
Experiments performed in this study did not require ethics board approval. Cell culture HAP1 cells were cultured in…