New signaling pathway enhances blood stem cell transplantation outcomes
Gene therapies are used to treat many different blood disorders. However, blood stem cells often fail to achieve…
New iron deficiency guidelines raise key blood test cutoffs
Could current blood test cutoffs be missing iron deficiency? New guidelines recommend higher ferritin thresholds for key patient…
New BCR analysis method tracks immune recovery after stem cell transplantation
A research team led by Associate Professor Yohei Funakoshi, Associate Professor Kimikazu Yakushijin, and Professor Hironobu Minami of…
Study uncovers how interferon-alpha treats rare blood cancers
The biologic drug interferon-alpha can benefit patients with blood cancers called myeloproliferative neoplasms by forcing mutant blood stem…
Study uncovers cellular mechanisms behind long-lasting antibody responses
A team led by investigators from the University of Osaka uncovers cellular mechanisms that favor long-lived antibody responses,…
New drug forces aggressive leukemia cells to die from stress
Pushing the accelerator and the brake at the same time is rarely a good idea. But researchers at…
Scientists map key differences in stem cell potency for treating knee osteoarthritis
Knee osteoarthritis (KOA) affects more than 1 in 10 people over 40 years of age, impairing patients’ mobility…
Yeast food supplement helps immune cells fight cancer more effectively
Researchers from Trinity College Dublin (TCD) and University College Dublin (UCD) have shown for the first time that…
Gut microbiome may determine bone loss severity in primary hyperparathyroidism
Primary hyperparathyroidism (PHPT) is a common endocrine disorder characterized by excessive secretion of parathyroid hormone (PTH). While some…
Researchers uncover new mechanism linking metabolism, immunity, and skeletal health
Obesity alters bone health not only through increased body weight but also by reshaping the bone marrow environment.…
Genetic mismatch identified as major risk factor in cord blood transplantation
A Japanese study of more than 7,400 patients has identified a genetic mismatch that sharply increases the risk…
Hypoxia rewires red blood cells to clear excess glucose
In a 2023 paper on hypoxia and glucose metabolism, our lab showed how organisms rewire their metabolism to…