New insights highlight multifaceted roles of CD4+ T cells in tumor immunity
For decades, cancer immunotherapy has focused primarily on CD8+ cytotoxic T lymphocytes as the main executors of tumor…
Study shows DHPS enzyme controls macrophage maturation across multiple organs
A new study led by researchers at the Johns Hopkins Kimmel Cancer Center, its Bloomberg~Kimmel Institute for Cancer Immunotherapy and the Johns…
Vitamin A derivative suppresses immune response and cancer vaccine efficacy
Scientists at the Princeton University Branch of the Ludwig Institute for Cancer Research have identified novel mechanisms by…
New study suggests a way to rejuvenate the immune system | MIT News
As people age, their immune system function declines. T cell populations become smaller and can’t react to pathogens…
Dietary restriction boosts antitumour immunity by rewiring T cell metabolism
By elevating ketone-driven energy pathways inside CD8+ T cells, dietary restriction steers them away from exhaustion and toward…
Neoantigens-loaded DC vaccines show strong potential to overcome tumor resistance
Despite the success of immune checkpoint inhibitors in revolutionizing oncology, their benefits remain limited to a small fraction…