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Browsing Tag

CD4

12 posts
HHealth
Study: CD4 CTLs in supercentenarians: Signs of adaptive expansion in healthy aging. Image Credit: Sean Pavone   / Shutterstock
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A striking immune cell pattern emerges around a person’s 100th birthday

  • August 24, 2026
Rare immune cells found at strikingly high levels in people who live beyond 110 reveal an unusual pattern…
HHealth
First FDA-approved islet transplant at UI Health ends insulin dependence
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Study identifies key immune cell changes in the lungs of people with sarcoidosis

  • August 10, 2026
Researchers at National Jewish Health and partner institutions discovered specific changes in immune cells in the lungs of…
TTechnology
New adaptive finger brace could improve recovery for joint injuries
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Pim1 identified as promising therapeutic target for inflammatory arthritis treatment

  • May 23, 2026
The research team led by Professor Zhongyu Xie from Sun Yat-sen University revealed a new mechanism by which…
HHealth
Innate immune activation and microglial transition during neurodegeneration. (A) During neurodegeneration, distressed neurons release DAMPs such as mtDNA, ROS, HMGB1, aberrant proteins, and pTau–bound RNA. These signals activate resident microglia and astrocytes, which then recruit peripheral immune cells. As shown in more detail in B, activated microglia upregulate PRRs, including TLRs, RAGE, and cGAS, enabling detection of neuron-derived DAMPs. Engagement of PRRs induces proinflammatory gene expression programs and activates inflammasome pathways that promote release of chemokines and cytokines into the CNS parenchyma. As microglia transition from homeostatic to reactive states in a TREM2-dependent manner, damage-associated microglia increase MHC-II expression to support antigen presentation and coordination of adaptive immune responses that attempt to limit neurodegeneration.
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How the immune system may influence Alzheimer’s, Parkinson’s, and related diseases

  • April 17, 2026
A sweeping review shows how the brain’s immune defenses can both fight and fuel neurodegeneration, revealing why timing,…
TTechnology
NYU Langone strengthens world-leading GI cancer program with renowned leaders
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New insights highlight multifaceted roles of CD4+ T cells in tumor immunity

  • March 14, 2026
For decades, cancer immunotherapy has focused primarily on CD8+ cytotoxic T lymphocytes as the main executors of tumor…
HHealth
Study: Engineering chimeric antigen receptor CD4 T cells for Alzheimer’s disease. Image Credit: Andrii Vodolazhskyi / Shutterstock
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Alzheimer’s plaques decline after CAR-T immune cell treatment in preclinical study

  • February 12, 2026
A novel CAR-T cell approach targets amyloid plaques in preclinical Alzheimer models, raising the possibility that engineered immune…
TTechnology
Study provides first worldwide validation of new GLIS model in older patients with heart failure
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Immune system dysfunction may fuel progressive heart failure after heart attacks

  • January 28, 2026
When the heart’s muscle is weakened or injured due to a heart attack, it can make it hard…
TTechnology
Study identifies PTX-3 as potential marker for long COVID and tissue damage
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Engineered extracellular vesicles enable antigen-specific regulatory T cell induction

  • December 23, 2025
A research team at the Nano Life Science Institute (WPI-NanoLSI) and the Faculty of Medicine at Kanazawa University…
HHealth
First FDA-approved islet transplant at UI Health ends insulin dependence
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Serious side effects after CAR T cell therapy for multiple myeloma share a common immune root cause

  • December 8, 2025
Serious side effects, including neurotoxicity and intestinal inflammation, that appear weeks or months after patients receive CAR T…
HHealth
Single-cell RNA sequencing uncovers diverse CD4⁺ T-cell subtypes in pediatric lupus
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Single-cell RNA sequencing uncovers diverse CD4⁺ T-cell subtypes in pediatric lupus

  • November 24, 2025
Detailed mapping of CD4⁺ T cells from children with systemic lupus erythematosus (SLE) has revealed distinct immune cell…
HHealth
Low-fat vegan diet shown to reduce insulin use and costs in type 1 diabetes
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New clues in pancreas lymph nodes, spleen could help detect and prevent type 1 diabetes

  • November 22, 2025
Type 1 diabetes (T1D) impacts nearly two million Americans, and by the time most people learn they have…
HHealth
Common food additives may trigger childhood asthma
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Common food additives may trigger childhood asthma

  • October 6, 2025
A recent study published in Frontiers in Immunology utilized metabolomics to investigate the mechanisms underlying the association between food…
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