Fred Hutch collaboration reveals molecular vulnerability in rare childhood brain cancer
When broken strands of DNA get repaired improperly, they can stitch together in new “Frankengene” fusions that can…
Study reveals how disordered proteins function without stable structure
A new LMU study shows how proteins function reliably even without a stable 3D structure – and the…
Vitamin B2 metabolism helps cancer cells resist ferroptosis
A lack of vitamin B2 makes tumor cells more susceptible to a unique form of cell death. This…
New insights highlight multifaceted roles of CD4+ T cells in tumor immunity
For decades, cancer immunotherapy has focused primarily on CD8+ cytotoxic T lymphocytes as the main executors of tumor…
CSF1R T567M mutation induces microglial dysfunction and synaptic impairment in patient iPSC-derived cerebral organoids of CSF1R-related disorder
Ayrignac X, Carra-Dalliere C, Codjia P, Mouzat K, Castelnovo G, Ellie E, et al. Evaluation of CSF1R-related adult…
Plant Cell Structure Could Hold Key to Cancer Therapies and Improved Crops
Can the bend of a banana give us insight into cancer? What does the shape of a rice…
Alpha-Ketoglutarate Enhances Adipose-Derived Stem Cells Survival in Wound Healing by Hypoxia-Inducible Factor 1-Alpha-Mediated Redox Homeostasis and Glycogen-Dependent Bioenergetics
BACKGROUND Adipose-derived stem cells (ADSCs) hold significant therapeutic potential for regenerative medicine, particularly in wound healing, owing to…
Stilbenoid gaylussacin modulates particulate matter-induced chromatin remodeling in macrophages to suppress chronic obstructive pulmonary disease
Chronic obstructive pulmonary disease (COPD), a leading cause of mortality worldwide, is characterized by chronic bronchitis and emphysema.1…
Senescent astrocytes identified as key drivers of Alzheimer’s progression
Researchers from the NeuroAD group (Neuropathology of Alzheimer’s Disease) within the Department of Cell Biology, Genetics and Physiology…
Asymmetric division rejuvenates stem cell lineages
You have full access to this article via your institution. Mouse embryonic stem cells maintain lineage immortality through…
Newly identified protein interaction fine-tunes cellular stress responses
Cornell researchers have discovered a new way cells regulate how they respond to stress, identifying an interaction between…
Power of Tiny Molecular ‘Flycatcher’ Surprises Through Disorder
BYLINE: Jenny Green Newswise — For decades, scientists assumed that order drives efficiency. Yet in the bustling machinery…