Tumor microenvironment drives resistance to ferroptosis in pancreatic cancer
Tumors driven by cancer-driving KRAS mutations are often susceptible to ferroptosis, a type of cell death that can…
Vitamin B2 metabolism helps cancer cells resist ferroptosis
A lack of vitamin B2 makes tumor cells more susceptible to a unique form of cell death. This…
Combined CDK4/6 and EGFR inhibition improves pancreatic cancer therapy
Clinically available KRAS inhibitors mainly target G12C, which is rare in PDAC and often acquires resistance. Oncogenic KRAS…
Dietary fat ratios impact the strength of immune cells and ability to fight disease
The types of fats we consume directly impacts the survival and strength of the body’s immune cells and…
Chlamydia pneumoniae found in the eye may aggravate Alzheimer’s disease
Chlamydia pneumoniae—a common bacterium that causes pneumonia and sinus infections—can linger in the eye and brain for years…
Dual pathways found for centromere specification, ensuring accurate chromosome segregation
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Despite the immense amount of genetic material present in each cell, around three…
Study reveals a therapeutic vulnerability in aggressive subtype of triple-negative breast cancer
Dec 26 2025 A new study published today in Science Translational Medicine by researchers at The University of…
Reframing the role of MCL1 in cancer signaling and metabolism
A study by the Mildred Scheel Early Career Center group led by Dr. Mohamed Elgendy at the TUD…
New tear gland organoids shed light on the biology of dry eye disease
An estimated 5-15% of people have problems with dry eyes, with symptoms including eye redness, stinging, or burning sensation, and eye fatigue. Dry…
Small molecule discovery could open the door to new class of treatments for hard-to-treat cancers
Researchers at the UCLA Health Jonsson Comprehensive Cancer Center have identified a small molecule that can inhibit a cancer-driving protein…
Novel antibody suppresses primary tumor growth and spread of triple-negative breast cancer
Triple-negative breast cancer (TNBC) is one of the most aggressive and treatment-resistant forms of breast cancer. It grows…
AR3-based optogenetic strategy shows high efficacy in inducing apoptosis and antitumor effects
One of the hallmarks of cancer cells is their ability to evade apoptosis, or programmed cell death, through…