Targeting mitochondrial vulnerabilities could help treat triple-negative breast cancer
A deeper understanding of mitochondrial function could create new opportunities for treating triple-negative breast cancer (TNBC), one of…
Cigarette smoke alters lung stem cells to drive specific cancers
Chronic exposure to cigarette smoke may reprogram different populations of lung stem cells, which maintain and repair lung…
The IGF2BP3/circDock1/TCF21 axis relieves chronic cerebral ischemic injury by regulating neuronal ferroptosis
Ferroptosis, a form of cell death driven by iron and lipid damage, exacerbates brain injury during chronic cerebral…
Fruit fly gut cells track hunger using internal cell viscosity
Researchers led by Sa Kan Yoo at the RIKEN Center for Biosystems Dynamics Research (BDR) in Japan have discovered that…
Autophagy modulation emerges as a strategy against cisplatin-resistant gastric cancer
Drug resistance remains one of the greatest obstacles to successful treatment of gastric cancer, limiting the long-term effectiveness…
New strategy combines cancer immunotherapy and gene therapy in a single nanoparticle
Cancer cells survive by hiding from the immune system’s surveillance. A KAIST research team has developed a new…
New biological feedback loop helps the immune system attack colorectal cancers
A subset of cancers, known as microsatellite instability (MSI) and deficient DNA mismatch repair (dMMR) cancers, are more…
Cell death crosstalk network drives acute respiratory distress syndrome
Acute respiratory distress syndrome (ARDS) remains one of the deadliest complications of severe infections, sepsis, trauma, and viral…
Experimental compound BA-101 overcomes chemotherapy resistance in glioblastoma
Scientists have identified a promising new strategy to tackle one of the biggest obstacles in treating glioblastoma, one…
Review links iron-dependent cell death to pathogenesis of Friedreich’s Ataxia
Published in the open-access journal Ferroptosis and Oxidative Stress, the review by Giovanni Cravin and Giorgio Cozza from the University of…
SLC7A11 deficiency exacerbates systemic lupus erythematosus by inducing instability and ferroptosis in regulatory T cells
Systemic lupus erythematosus (SLE) is an autoimmune disease posing a significant threat to human health. Regulatory T cells…
Developing brain cells routinely repair severe DNA damage during migration
Newborn nerve cells must squeeze through crowded, narrow spaces-through dense tissue, past other cells, between fibers-to reach the…