Reframing the role of MCL1 in cancer signaling and metabolism
A study by the Mildred Scheel Early Career Center group led by Dr. Mohamed Elgendy at the TUD…
New tear gland organoids shed light on the biology of dry eye disease
An estimated 5-15% of people have problems with dry eyes, with symptoms including eye redness, stinging, or burning sensation, and eye fatigue. Dry…
Small molecule discovery could open the door to new class of treatments for hard-to-treat cancers
Researchers at the UCLA Health Jonsson Comprehensive Cancer Center have identified a small molecule that can inhibit a cancer-driving protein…
Novel antibody suppresses primary tumor growth and spread of triple-negative breast cancer
Triple-negative breast cancer (TNBC) is one of the most aggressive and treatment-resistant forms of breast cancer. It grows…
AR3-based optogenetic strategy shows high efficacy in inducing apoptosis and antitumor effects
One of the hallmarks of cancer cells is their ability to evade apoptosis, or programmed cell death, through…
Innate immunity and metabolic stress drive a unique form of cell death
In several disease conditions, including infections and cancers, innate immune activation and nutrient scarcity occur together. A study…
Inflammation control can protect against AMD-like retinal damage
University of Minnesota Medical School researchers have shown that reducing chronic inflammation can significantly protect against age-related macular…
Innovative research reveals FGD3 as a key player in breast cancer cell death
A naturally occurring protein that tends to be expressed at higher levels in breast cancer cells boosts the…
Study uncovers new mechanism for chromosome congression during mitosis
A research team from The University of Osaka, in collaboration with the Massachusetts Institute of Technology, has uncovered…
How walnuts combat inflammation and oxidative stress in the body
From protecting brain cells to modulating immunity, walnut bioactives demonstrate remarkable antioxidant and anti-inflammatory potential; however, scientists caution…
Researchers identify new molecular switch involved in programmed cell death
In the fight against disease, programmed cell death – also known as apoptosis – is a key protective…
Lactate and lactylation drive metabolic, epigenetic reprogramming in gynecological cancers
Lactate, once considered a metabolic waste product, is now recognized as a key regulator of cellular homeostasis and…