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Browsing Tag

Chemokines

4 posts
SScience
Experimental RNA drug shows promise for repairing DNA and healing tissue damage
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Three decades of progress since the discovery of senescence-associated beta-galactosidase

  • June 6, 2026
A new review was published in Volume 18 of Aging on May 15, 2026, titled “Blue period – features of…
HHealth
Innate immune activation and microglial transition during neurodegeneration. (A) During neurodegeneration, distressed neurons release DAMPs such as mtDNA, ROS, HMGB1, aberrant proteins, and pTau–bound RNA. These signals activate resident microglia and astrocytes, which then recruit peripheral immune cells. As shown in more detail in B, activated microglia upregulate PRRs, including TLRs, RAGE, and cGAS, enabling detection of neuron-derived DAMPs. Engagement of PRRs induces proinflammatory gene expression programs and activates inflammasome pathways that promote release of chemokines and cytokines into the CNS parenchyma. As microglia transition from homeostatic to reactive states in a TREM2-dependent manner, damage-associated microglia increase MHC-II expression to support antigen presentation and coordination of adaptive immune responses that attempt to limit neurodegeneration.
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How the immune system may influence Alzheimer’s, Parkinson’s, and related diseases

  • April 17, 2026
A sweeping review shows how the brain’s immune defenses can both fight and fuel neurodegeneration, revealing why timing,…
HHealth
Affordable drug found to be effective in treating seriously ill COVID-19 patients
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Study revises the understanding of neutrophil dynamics during respiratory viral infection

  • March 24, 2026
Neutrophil infiltration is a hallmark of pulmonary inflammation during respiratory viral infections, yet the origin of these cells…
HHealth
NYU Langone strengthens world-leading GI cancer program with renowned leaders
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Tick-derived protein discovery can advance treatment for inflammatory diseases

  • February 28, 2026
When the immune system detects a harmful or foreign agent it triggers an inflammatory response small proteins called…
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